Assessment of erlotinib pharmacodynamics in tumors and skin of patients with head and neck cancer

Background: The purpose of the study was to evaluate the effects of erlotinib on epidermal growth factor receptor (EGFR)-related signaling elements in tumor and skin from patients with advanced squamous cell carcinoma of the head and neck (HNSCC) and seek relationships between relevant clinical, bio...

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Veröffentlicht in:	Annals of oncology 2007-04, Vol.18 (4), p.761-767
Hauptverfasser:	Calvo, E, Malik, SN, Siu, LL, Baillargeon, GM, Irish, J, Chin, SF, Santabarbara, P, Kreisberg, JI, Rowinsky, EK, Hidalgo, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antineoplastic agents Biological and medical sciences Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - mortality Cyclin-Dependent Kinase Inhibitor p27 - analysis EGFR ErbB Receptors - analysis erlotinib Erlotinib Hydrochloride Extracellular Signal-Regulated MAP Kinases - analysis Female head and neck cancer Head and Neck Neoplasms - chemistry Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - mortality Humans Immunohistochemistry Male Medical sciences Middle Aged Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology pharmacodynamics Pharmacology. Drug treatments Quinazolines - adverse effects Quinazolines - therapeutic use Skin - drug effects translational Tumors
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