Streptozotocin-induced hippocampal astrogliosis and insulin signaling malfunction as experimental scales for subclinical sporadic Alzheimer model

Insulin signaling malfunction has recently been suggested as a preliminary event involved in the etiology of Sporadic Alzheimer's disease (SAD). In order to develop insulin resistance-related SAD model, rats were treated with streptozotocin, intracerebroventricularly (icv-STZ). Nevertheless, gi...

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Veröffentlicht in:	Life sciences (1973) 2017-11, Vol.188, p.172-185
Hauptverfasser:	Rostami, Farzaneh, Javan, Mohammad, Moghimi, Ali, Haddad-Mashadrizeh, Aliakbar, Fereidoni, Masoud
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - diagnosis Alzheimer's disease Animals Astrocytes - pathology Choline O-Acetyltransferase - biosynthesis Cognitive ability Disease Models, Animal Dose-Response Relationship, Drug Etiology Exploratory Behavior - drug effects Gliosis Gliosis - chemically induced Gliosis - pathology Hippocampus Hippocampus - pathology Inflammation Infrared radiation Infusions, Intraventricular Insulin Insulin - metabolism Insulin Resistance Laboratory equipment Male Maze Learning - drug effects mRNA Neurodegenerative diseases Neurons - pathology Non-transgenic sAD model Pre-clinical stages Prodromal Symptoms Rats Receptor, Insulin - biosynthesis Recognition (Psychology) - drug effects Rodent Rodents Rotarod Performance Test Signaling Streptozocin Streptozocin - administration & dosage Streptozocin - adverse effects Streptozotocin Tau protein tau Proteins - biosynthesis Testing time Thickness Time Factors
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