Development and characterization of miltefosine-loaded polymeric micelles for cancer treatment

Miltefosine presents antineoplastic activity but high hemolytic potential. Its use in cancer has been limited to treating cutaneous metastasis of breast cancer. To decrease hemolytic potential, we developed a formulation of miltefosine-loaded polymeric micelles (PM) of the copolymer Pluronic-F127. A...

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Veröffentlicht in:	Materials Science & Engineering C 2017-12, Vol.81, p.327-333
Hauptverfasser:	Valenzuela-Oses, Johanna K., García, Mónica C., Feitosa, Valker A., Pachioni-Vasconcelos, Juliana A., Gomes-Filho, Sandro M., Lourenço, Felipe R., Cerize, Natalia N.P., Bassères, Daniela S., Rangel-Yagui, Carlota O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylphosphocholines Block-copolymer Breast cancer Cancer Cancer therapies Cancer therapy Cell Line, Tumor Copolymers Cytotoxicity Hemolytic potential Humans Materials science Metastases Metastasis Micelles Miltefosine Phosphorylcholine - analogs & derivatives Phosphorylcholine - chemistry Poloxamer Polydispersity Polymeric micelles Polymers Toxicity Variance analysis
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