Chiral phosphite-type ligands based on ((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) ((R,R)-TADDOL) with peripheral arylamino groups

Chiral phosphite-type ligands based on ((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) ((R,R)-TADDOL) with peripheral arylamino groups

New phosphite and amidophosphite inductors of chirality were obtained based on ((4 R ,5 R )-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (( R , R )-TADDOL) containing arylamino groups in the exocyclic substituents. Their use in the palladium-catalyzed enantioselective alkylation of ( E...

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Veröffentlicht in:Russian chemical bulletin 2017-07, Vol.66 (7), p.1265-1268
Hauptverfasser: Gavrilov, K. N., Maksimova, M. G., Chuchelkin, I. V., Lugovsky, V. V., Zheglov, S. V., Gavrilov, V. K., Perepukhov, A. M.
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chirality
Full Articles
Inductors
Inorganic Chemistry
Organic Chemistry
Palladium
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Zusammenfassung:New phosphite and amidophosphite inductors of chirality were obtained based on ((4 R ,5 R )-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (( R , R )-TADDOL) containing arylamino groups in the exocyclic substituents. Their use in the palladium-catalyzed enantioselective alkylation of ( E )-1,3-diphenylallyl acetate with dimethyl malonate gave the ee value up to 98%.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-017-1883-8