Environmental tobacco smoke exposure and EGFR and ALK alterations in never smokers' lung cancer. Results from the LCRINS study

Environmental tobacco smoke (ETS) exposure is a main risk factor of lung cancer in never smokers. Epidermal Growth Factor Receptor (EGFR) mutations and ALK translocations are more frequent in never smokers' lung cancer than in ever-smokers. We performed a multicenter case-control study to asses...

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Veröffentlicht in:	Cancer letters 2017-12, Vol.411, p.130-135
Hauptverfasser:	Torres-Durán, María, Ruano-Ravina, Alberto, Kelsey, Karl T., Parente-Lamelas, Isaura, Leiro-Fernández, Virginia, Abdulkader, Ihab, Provencio, Mariano, Abal-Arca, José, Castro-Añón, Olalla, Montero-Martínez, Carmen, Vidal-García, Iria, Amenedo, Margarita, Golpe-Gómez, Antonio, Martínez, Cristina, Guzmán-Taveras, Rosirys, Mejuto-Martí, María José, Fernández-Villar, Alberto, Barros-Dios, Juan Miguel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Aged Aged, 80 and over ALK Carcinogens Case-Control Studies Case-control study Children Ecological risk assessment Environmental tobacco smoke Epidermal growth factor Epidermal growth factor receptor Epidermal growth factor receptors Exposure Female Health risk assessment Health risks Humans Lung cancer Lung neoplasms Lung Neoplasms - enzymology Lung Neoplasms - etiology Lung Neoplasms - genetics Lung Neoplasms - pathology Male Medical prognosis Middle Aged Mutation Never-smokers Occupational exposure Passive smoking Public health Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Risk Factors Smoke Smoking Tobacco Tobacco smoke Tobacco Smoke Pollution - adverse effects Tobacco Smoke Pollution - analysis
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