Sugar‐Incorporated N‐Heterocyclic‐Carbene‐Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation
A series of neutral and cationic gold(I) complexes bearing a glucopyranoside‐incorporated N‐heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. Different secondary ligands (chlorido, phosphane, or sugar–NHC) are employed to tune the properties of the complexes. The anti...
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| Veröffentlicht in: | European journal of inorganic chemistry 2017-11, Vol.2017 (42), p.4955-4961 |
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| container_end_page | 4961 |
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| container_issue | 42 |
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| container_title | European journal of inorganic chemistry |
| container_volume | 2017 |
| creator | Cucciolito, Maria E. Trinchillo, Marina Iannitti, Roberta Palumbo, Rosanna Tesauro, Diego Tuzi, Angela Ruffo, Francesco D'Amora, Angela |
| description | A series of neutral and cationic gold(I) complexes bearing a glucopyranoside‐incorporated N‐heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. Different secondary ligands (chlorido, phosphane, or sugar–NHC) are employed to tune the properties of the complexes. The antiproliferative effects of the compounds are evaluated against PC‐3 prostate cancer cells and a panel of human tumor cell lines. The activities of the phosphane complexes are comparable to that observed for cisplatin. The combined results provide further insights into the biological behavior of NHC–gold complexes.
A series of neutral and cationic gold(I) complexes bearing a glucopyranoside‐incorporated N‐heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. The antiproliferative effects of the compounds are evaluated against PC‐3 prostate cancer cells and a panel of human tumor cell lines. |
| doi_str_mv | 10.1002/ejic.201700768 |
| format | Article |
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A series of neutral and cationic gold(I) complexes bearing a glucopyranoside‐incorporated N‐heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. The antiproliferative effects of the compounds are evaluated against PC‐3 prostate cancer cells and a panel of human tumor cell lines.</description><identifier>ISSN: 1434-1948</identifier><identifier>EISSN: 1099-0682</identifier><identifier>DOI: 10.1002/ejic.201700768</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Bioconjugation ; Biological effects ; Carbene ligands ; Carbohydrates ; Cytotoxity ; Gold ; Inorganic chemistry ; Prostate ; Prostate cancer</subject><ispartof>European journal of inorganic chemistry, 2017-11, Vol.2017 (42), p.4955-4961</ispartof><rights>2017 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3178-d798b0bafd362d9b6a58c9bdff8fff0089d5391e9df4b2d8ae00bfab2195a3e83</citedby><cites>FETCH-LOGICAL-c3178-d798b0bafd362d9b6a58c9bdff8fff0089d5391e9df4b2d8ae00bfab2195a3e83</cites><orcidid>0000-0002-1556-2562 ; 0000-0002-7904-9602 ; 0000-0002-3858-4529 ; 0000-0003-1624-079X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fejic.201700768$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fejic.201700768$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Cucciolito, Maria E.</creatorcontrib><creatorcontrib>Trinchillo, Marina</creatorcontrib><creatorcontrib>Iannitti, Roberta</creatorcontrib><creatorcontrib>Palumbo, Rosanna</creatorcontrib><creatorcontrib>Tesauro, Diego</creatorcontrib><creatorcontrib>Tuzi, Angela</creatorcontrib><creatorcontrib>Ruffo, Francesco</creatorcontrib><creatorcontrib>D'Amora, Angela</creatorcontrib><title>Sugar‐Incorporated N‐Heterocyclic‐Carbene‐Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation</title><title>European journal of inorganic chemistry</title><description>A series of neutral and cationic gold(I) complexes bearing a glucopyranoside‐incorporated N‐heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. Different secondary ligands (chlorido, phosphane, or sugar–NHC) are employed to tune the properties of the complexes. The antiproliferative effects of the compounds are evaluated against PC‐3 prostate cancer cells and a panel of human tumor cell lines. The activities of the phosphane complexes are comparable to that observed for cisplatin. The combined results provide further insights into the biological behavior of NHC–gold complexes.
A series of neutral and cationic gold(I) complexes bearing a glucopyranoside‐incorporated N‐heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. The antiproliferative effects of the compounds are evaluated against PC‐3 prostate cancer cells and a panel of human tumor cell lines.</description><subject>Bioconjugation</subject><subject>Biological effects</subject><subject>Carbene ligands</subject><subject>Carbohydrates</subject><subject>Cytotoxity</subject><subject>Gold</subject><subject>Inorganic chemistry</subject><subject>Prostate</subject><subject>Prostate cancer</subject><issn>1434-1948</issn><issn>1099-0682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFUD1PwzAQjRBIlMLKHIkFpKac4zS12VBU2qIKhsIcOf5oXaV2sVNomFjY-Y38ElKKYGS6d3fvQ3pBcIqgiwDiS7nQvBsD6gP0U7IXtBBQGkFK4v0GJziJEE3IYXDk_QIAMOC0FbxP1zPmPt8-xoZbt7KOVVKEd81hJCvpLK95qXmzZswV0sgtsqZi2mgzC4e2FOfjizCzy1UpN9JfhdPaVHPpte-E2Zw5xhsX_coqbU0nZEaEWV3Zym40DwfPrFx_f46DA8VKL09-Zjt4vBk8ZKNocj8cZ9eTiGPUJ5HoU1JAwZTAaSxokbIe4bQQShGlFAChoocpklSopIgFYRKgUKyIEe0xLAluB2c735WzT2vpq3xh1840kTmiaZKkCGLcsLo7FnfWeydVvnJ6yVydI8i3VefbqvPfqhsB3QledCnrf9j54Hac_Wm_APlxido</recordid><startdate>20171116</startdate><enddate>20171116</enddate><creator>Cucciolito, Maria E.</creator><creator>Trinchillo, Marina</creator><creator>Iannitti, Roberta</creator><creator>Palumbo, Rosanna</creator><creator>Tesauro, Diego</creator><creator>Tuzi, Angela</creator><creator>Ruffo, Francesco</creator><creator>D'Amora, Angela</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-1556-2562</orcidid><orcidid>https://orcid.org/0000-0002-7904-9602</orcidid><orcidid>https://orcid.org/0000-0002-3858-4529</orcidid><orcidid>https://orcid.org/0000-0003-1624-079X</orcidid></search><sort><creationdate>20171116</creationdate><title>Sugar‐Incorporated N‐Heterocyclic‐Carbene‐Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation</title><author>Cucciolito, Maria E. ; Trinchillo, Marina ; Iannitti, Roberta ; Palumbo, Rosanna ; Tesauro, Diego ; Tuzi, Angela ; Ruffo, Francesco ; D'Amora, Angela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3178-d798b0bafd362d9b6a58c9bdff8fff0089d5391e9df4b2d8ae00bfab2195a3e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Bioconjugation</topic><topic>Biological effects</topic><topic>Carbene ligands</topic><topic>Carbohydrates</topic><topic>Cytotoxity</topic><topic>Gold</topic><topic>Inorganic chemistry</topic><topic>Prostate</topic><topic>Prostate cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cucciolito, Maria E.</creatorcontrib><creatorcontrib>Trinchillo, Marina</creatorcontrib><creatorcontrib>Iannitti, Roberta</creatorcontrib><creatorcontrib>Palumbo, Rosanna</creatorcontrib><creatorcontrib>Tesauro, Diego</creatorcontrib><creatorcontrib>Tuzi, Angela</creatorcontrib><creatorcontrib>Ruffo, Francesco</creatorcontrib><creatorcontrib>D'Amora, Angela</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>European journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cucciolito, Maria E.</au><au>Trinchillo, Marina</au><au>Iannitti, Roberta</au><au>Palumbo, Rosanna</au><au>Tesauro, Diego</au><au>Tuzi, Angela</au><au>Ruffo, Francesco</au><au>D'Amora, Angela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sugar‐Incorporated N‐Heterocyclic‐Carbene‐Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation</atitle><jtitle>European journal of inorganic chemistry</jtitle><date>2017-11-16</date><risdate>2017</risdate><volume>2017</volume><issue>42</issue><spage>4955</spage><epage>4961</epage><pages>4955-4961</pages><issn>1434-1948</issn><eissn>1099-0682</eissn><abstract>A series of neutral and cationic gold(I) complexes bearing a glucopyranoside‐incorporated N‐heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. 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A series of neutral and cationic gold(I) complexes bearing a glucopyranoside‐incorporated N‐heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. The antiproliferative effects of the compounds are evaluated against PC‐3 prostate cancer cells and a panel of human tumor cell lines.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/ejic.201700768</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1556-2562</orcidid><orcidid>https://orcid.org/0000-0002-7904-9602</orcidid><orcidid>https://orcid.org/0000-0002-3858-4529</orcidid><orcidid>https://orcid.org/0000-0003-1624-079X</orcidid></addata></record> |
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| language | eng |
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| source | Wiley Online Library All Journals |
| subjects | Bioconjugation Biological effects Carbene ligands Carbohydrates Cytotoxity Gold Inorganic chemistry Prostate Prostate cancer |
| title | Sugar‐Incorporated N‐Heterocyclic‐Carbene‐Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation |
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