Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients
We comparatively analyzed serially autopsied, elderly Japanese patients (n = 2205) with pancreatic intraepithelial neoplasias (PanINs) and pancreatic ductal adenocarcinomas (PDACs) on the basis of their pancreatic lesions, clinical information, and single nucleotide polymorphisms (SNPs). The inciden...
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| Veröffentlicht in: | Genes chromosomes & cancer 2018-01, Vol.57 (1), p.12-18 |
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| creator | Matsuda, Yoko Tanaka, Masashi Sawabe, Motoji Mori, Seijiro Muramatsu, Masaaki Mieno, Makiko Naka Furukawa, Toru Arai, Tomio |
| description | We comparatively analyzed serially autopsied, elderly Japanese patients (n = 2205) with pancreatic intraepithelial neoplasias (PanINs) and pancreatic ductal adenocarcinomas (PDACs) on the basis of their pancreatic lesions, clinical information, and single nucleotide polymorphisms (SNPs). The incidence of PanIN‐1, −2, −3, and PDACs in these patients was 55%, 12%, 1.4%, and 2.4%, respectively. The occurrence of PanINs was associated with female sex, increasing age, and lower body mass index. We did not identify any common SNPs between PanINs and PDACs. There were no common SNPs associated with PanINs and PDACs between men and women. In previously reported pancreatic cancer‐associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort. Six SNPs (rs7016880, rs10096633, rs10503669, rs12678919, rs17482753, rs328) that were correlated with blood lipid levels were associated with the risk for PDACs. Our data suggest that different clinicopathological characteristics and predispositions may affect pancreatic carcinogenesis in elderly Japanese patients. |
| doi_str_mv | 10.1002/gcc.22479 |
| format | Article |
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The incidence of PanIN‐1, −2, −3, and PDACs in these patients was 55%, 12%, 1.4%, and 2.4%, respectively. The occurrence of PanINs was associated with female sex, increasing age, and lower body mass index. We did not identify any common SNPs between PanINs and PDACs. There were no common SNPs associated with PanINs and PDACs between men and women. In previously reported pancreatic cancer‐associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort. Six SNPs (rs7016880, rs10096633, rs10503669, rs12678919, rs17482753, rs328) that were correlated with blood lipid levels were associated with the risk for PDACs. Our data suggest that different clinicopathological characteristics and predispositions may affect pancreatic carcinogenesis in elderly Japanese patients.</description><identifier>ISSN: 1045-2257</identifier><identifier>EISSN: 1098-2264</identifier><identifier>DOI: 10.1002/gcc.22479</identifier><identifier>PMID: 28639428</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - pathology ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Autopsies ; Body mass ; Body Mass Index ; Carcinogenesis ; Carcinoma in Situ - genetics ; Carcinoma in Situ - pathology ; Carcinoma, Pancreatic Ductal - genetics ; Carcinoma, Pancreatic Ductal - pathology ; Female ; Geriatrics ; Humans ; Lesions ; Lipids - blood ; Male ; Middle Aged ; Older people ; Pancreatic cancer ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - pathology ; Polymorphism ; Polymorphism, Single Nucleotide ; Receptors, Cytoplasmic and Nuclear - genetics ; Sex Factors ; Single-nucleotide polymorphism</subject><ispartof>Genes chromosomes & cancer, 2018-01, Vol.57 (1), p.12-18</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4639-3c9b1cd7f416e1a95027f01eb4a55135fa178734e4094044b0b186a44f77d36f3</citedby><cites>FETCH-LOGICAL-c4639-3c9b1cd7f416e1a95027f01eb4a55135fa178734e4094044b0b186a44f77d36f3</cites><orcidid>0000-0002-3235-655X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgcc.22479$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgcc.22479$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28639428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuda, Yoko</creatorcontrib><creatorcontrib>Tanaka, Masashi</creatorcontrib><creatorcontrib>Sawabe, Motoji</creatorcontrib><creatorcontrib>Mori, Seijiro</creatorcontrib><creatorcontrib>Muramatsu, Masaaki</creatorcontrib><creatorcontrib>Mieno, Makiko Naka</creatorcontrib><creatorcontrib>Furukawa, Toru</creatorcontrib><creatorcontrib>Arai, Tomio</creatorcontrib><title>Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients</title><title>Genes chromosomes & cancer</title><addtitle>Genes Chromosomes Cancer</addtitle><description>We comparatively analyzed serially autopsied, elderly Japanese patients (n = 2205) with pancreatic intraepithelial neoplasias (PanINs) and pancreatic ductal adenocarcinomas (PDACs) on the basis of their pancreatic lesions, clinical information, and single nucleotide polymorphisms (SNPs). The incidence of PanIN‐1, −2, −3, and PDACs in these patients was 55%, 12%, 1.4%, and 2.4%, respectively. The occurrence of PanINs was associated with female sex, increasing age, and lower body mass index. We did not identify any common SNPs between PanINs and PDACs. There were no common SNPs associated with PanINs and PDACs between men and women. In previously reported pancreatic cancer‐associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort. Six SNPs (rs7016880, rs10096633, rs10503669, rs12678919, rs17482753, rs328) that were correlated with blood lipid levels were associated with the risk for PDACs. Our data suggest that different clinicopathological characteristics and predispositions may affect pancreatic carcinogenesis in elderly Japanese patients.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autopsies</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Carcinogenesis</subject><subject>Carcinoma in Situ - genetics</subject><subject>Carcinoma in Situ - pathology</subject><subject>Carcinoma, Pancreatic Ductal - genetics</subject><subject>Carcinoma, Pancreatic Ductal - pathology</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Lesions</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, Cytoplasmic and Nuclear - genetics</subject><subject>Sex Factors</subject><subject>Single-nucleotide polymorphism</subject><issn>1045-2257</issn><issn>1098-2264</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVtLBCEYhiWKttNFfyCEroK2dMY5XcbSCRaCqOvB0W92XRw1dYj9N_3U3Laim6580cfnQ1-ETim5ooRk1wshrrKMVc0OOqCkqadZVrLdTWZFykU1QYchrAghZd4U-2iS1SmwrD5AH8-geVTWhKVyuIP4DmCw40Z4SPsCKxM9B6fiErTiGhuwTvOgeLj8i8lRxHTKJRgruBfK2GGDcCNxUGahAZtRaLBRScDO6vVgvVuqMIQ0AvMxWhcUSAxagtfr5I4KTAzHaK_nOsDJ93qEXu9uX2YP0_nT_ePsZj4VLL1lmoumo0JWPaMlUN4UJKt6QqFjvChoXvScVnWVM2CkYYSxjnS0LjljfVXJvOzzI3S-9Tpv30YIsV3Z0Zs0sqVNmddFupwn6mJLCW9D8NC3zquB-3VLSbvpok1dtF9dJPbs2zh2A8hf8ufzE3C9Bd6VhvX_pvZ-NtsqPwG7Qpcj</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Matsuda, Yoko</creator><creator>Tanaka, Masashi</creator><creator>Sawabe, Motoji</creator><creator>Mori, Seijiro</creator><creator>Muramatsu, Masaaki</creator><creator>Mieno, Makiko Naka</creator><creator>Furukawa, Toru</creator><creator>Arai, Tomio</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-3235-655X</orcidid></search><sort><creationdate>201801</creationdate><title>Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients</title><author>Matsuda, Yoko ; Tanaka, Masashi ; Sawabe, Motoji ; Mori, Seijiro ; Muramatsu, Masaaki ; Mieno, Makiko Naka ; Furukawa, Toru ; Arai, Tomio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4639-3c9b1cd7f416e1a95027f01eb4a55135fa178734e4094044b0b186a44f77d36f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autopsies</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Carcinogenesis</topic><topic>Carcinoma in Situ - genetics</topic><topic>Carcinoma in Situ - pathology</topic><topic>Carcinoma, Pancreatic Ductal - genetics</topic><topic>Carcinoma, Pancreatic Ductal - pathology</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Lesions</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, Cytoplasmic and Nuclear - genetics</topic><topic>Sex Factors</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuda, Yoko</creatorcontrib><creatorcontrib>Tanaka, Masashi</creatorcontrib><creatorcontrib>Sawabe, Motoji</creatorcontrib><creatorcontrib>Mori, Seijiro</creatorcontrib><creatorcontrib>Muramatsu, Masaaki</creatorcontrib><creatorcontrib>Mieno, Makiko Naka</creatorcontrib><creatorcontrib>Furukawa, Toru</creatorcontrib><creatorcontrib>Arai, Tomio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Genes chromosomes & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuda, Yoko</au><au>Tanaka, Masashi</au><au>Sawabe, Motoji</au><au>Mori, Seijiro</au><au>Muramatsu, Masaaki</au><au>Mieno, Makiko Naka</au><au>Furukawa, Toru</au><au>Arai, Tomio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients</atitle><jtitle>Genes chromosomes & cancer</jtitle><addtitle>Genes Chromosomes Cancer</addtitle><date>2018-01</date><risdate>2018</risdate><volume>57</volume><issue>1</issue><spage>12</spage><epage>18</epage><pages>12-18</pages><issn>1045-2257</issn><eissn>1098-2264</eissn><abstract>We comparatively analyzed serially autopsied, elderly Japanese patients (n = 2205) with pancreatic intraepithelial neoplasias (PanINs) and pancreatic ductal adenocarcinomas (PDACs) on the basis of their pancreatic lesions, clinical information, and single nucleotide polymorphisms (SNPs). The incidence of PanIN‐1, −2, −3, and PDACs in these patients was 55%, 12%, 1.4%, and 2.4%, respectively. The occurrence of PanINs was associated with female sex, increasing age, and lower body mass index. We did not identify any common SNPs between PanINs and PDACs. There were no common SNPs associated with PanINs and PDACs between men and women. In previously reported pancreatic cancer‐associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort. Six SNPs (rs7016880, rs10096633, rs10503669, rs12678919, rs17482753, rs328) that were correlated with blood lipid levels were associated with the risk for PDACs. Our data suggest that different clinicopathological characteristics and predispositions may affect pancreatic carcinogenesis in elderly Japanese patients.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28639428</pmid><doi>10.1002/gcc.22479</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3235-655X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma - pathology Adult Age Factors Aged Aged, 80 and over Autopsies Body mass Body Mass Index Carcinogenesis Carcinoma in Situ - genetics Carcinoma in Situ - pathology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Female Geriatrics Humans Lesions Lipids - blood Male Middle Aged Older people Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Polymorphism Polymorphism, Single Nucleotide Receptors, Cytoplasmic and Nuclear - genetics Sex Factors Single-nucleotide polymorphism |
| title | Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients |
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