Limited ability of DNA polymerase kappa to suppress benzo[a]pyrene‐induced genotoxicity in vivo

DNA polymerase kappa (Polk) is a specialized DNA polymerase involved in translesion DNA synthesis. To understand the protective roles against genotoxins in vivo, we established inactivated Polk knock‐in gpt delta (inactivated Polk KI) mice that possessed reporter genes for mutations and expressed in...

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Veröffentlicht in:	Environmental and molecular mutagenesis 2017-12, Vol.58 (9), p.644-653
Hauptverfasser:	Masumura, Kenichi, Toyoda‐Hokaiwado, Naomi, Niimi, Naoko, Grúz, Petr, Wada, Naoko A., Takeiri, Akira, Jishage, Kou‐ichi, Mishima, Masayuki, Nohmi, Takehiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Age aging Animals Benzo(a)pyrene Benzo(a)pyrene - toxicity Bone marrow Carcinogenesis Carcinogens catalytically‐dead knock‐in mice Cell culture Chemical synthesis Colon Deoxyribonucleic acid DNA DNA - biosynthesis DNA - drug effects DNA - genetics DNA Damage - drug effects DNA Damage - genetics DNA polymerase DNA Repair - drug effects DNA Repair - genetics DNA Replication - drug effects DNA Replication - genetics DNA-directed DNA polymerase DNA-Directed DNA Polymerase - genetics Genotoxicity gpt delta mice In vivo methods and tests Knock Mice Mutagenesis Mutagenesis - drug effects Mutagenesis - genetics Mutant frequency Mutation Peripheral blood Pyrene translesion DNA synthesis
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