Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced ß-Cell Apoptosis and JNK Pathway Activation

Islet amyloid is present in more than 90% of individuals with type 2 diabetes, where it contributes to β-cell apoptosis and insufficient insulin secretion. Apoptosis repressor with caspase recruitment domain (ARC) binds and inactivates components of the intrinsic and extrinsic apoptosis pathways and...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2017-10, Vol.66 (10), p.2636
Hauptverfasser:	Templin, Andrew T, Samarasekera, Tanya, Meier, Daniel T, Hogan, Meghan F, Mellati, Mahnaz, Crow, Michael T, Kitsis, Richard N, Zraika, Sakeneh, Hull, Rebecca L, Kahn, Steven E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylin Amyloidosis Apoptosis c-Jun protein Caspase Diabetes Diabetes mellitus Gene expression Immunoprecipitation Insulin Insulin secretion JNK protein Kinases Lysates Phosphorylation Signal transduction Transcription factors Transgenic mice Tumor necrosis factor β-Amyloid
Online-Zugang:	Volltext
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