Acute ethanol exposure‐induced autophagy‐mediated cardiac injury via activation of the ROS‐JNK‐Bcl‐2 pathway

Binge drinking is associated with increased cardiac autophagy, and often triggers heart injury. Given the essential role of autophagy in various cardiac diseases, this study was designed to investigate the role of autophagy in ethanol‐induced cardiac injury and the underlying mechanism. Our study sh...

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Veröffentlicht in:	Journal of cellular physiology 2018-02, Vol.233 (2), p.924-935
Hauptverfasser:	Zhu, Zhongxin, Huang, Yewei, Lv, Lingchun, Tao, Youli, Shao, Minglong, Zhao, Congcong, Xue, Mei, Sun, Jia, Niu, Chao, Wang, Yang, Kim, Sunam, Cong, Weitao, Mao, Wei, Jin, Litai
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Activation Animals Antioxidants Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Bcl-2 protein Binge drinking Biocompatibility cardiac function Cardiomyocytes Cardiomyopathy, Alcoholic - enzymology Cardiomyopathy, Alcoholic - pathology Cardiotoxicity Cells, Cultured Coronary artery disease Disease Models, Animal Drinking behavior Ethanol Exposure Genetic Predisposition to Disease Heart Heart diseases Injuries JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - metabolism JNK protein Male Metallothionein Mice Mice, Inbred C57BL Mice, Transgenic Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology Nitrogen Phagocytosis Pharmacology Phenotype Phosphorylation Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-bcl-2 - metabolism Rats, Sprague-Dawley Reactive nitrogen species Reactive oxygen species Reactive Oxygen Species - metabolism ROS‐JNK Signal Transduction Signaling Time Factors Toxicity Transcription factors
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