Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells

Bisphenols are endocrine disruptors that are widely found in the environment. Accumulating experimental evidence suggests an adverse interaction between bisphenols and estrogen signaling. Most studies have performed experiments that focused on estrogen receptor (ER) engagement by bisphenols. Therefo...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2017/11/01, Vol.40(11), pp.1909-1916
Hauptverfasser:	Okazaki, Hiroyuki, Takeda, Shuso, Kakizoe, Kazuhiro, Taniguchi, Aya, Tokuyasu, Miki, Himeno, Taichi, Ishii, Hiroyuki, Kohro-Ikeda, Eriko, Haraguchi, Koichi, Watanabe, Kazuhito, Aramaki, Hironori
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol anti-estrogenic compound Benzhydryl Compounds - pharmacology Bisphenol A bisphenol AF Bisphenols Breast cancer Cdc2 protein CDC2 Protein Kinase - metabolism Dose-Response Relationship, Drug Down-Regulation Endocrine disruptors Endocrine Disruptors - pharmacology Estradiol - metabolism Estrogen Antagonists - pharmacology Estrogen Receptor alpha - agonists Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism estrogen receptor β Estrogen receptors Estrogens Estrogens - metabolism Female Humans MCF-7 cell MCF-7 Cells Phenols Phenols - pharmacology Response Elements - drug effects Sex hormones Signal Transduction - drug effects Transcription Transcription, Genetic - drug effects Tumor cell lines Up-Regulation Xenoestrogens
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