Shear Stress Modulates Resistin-Induced CC Chemokine Ligand 19 Expression in Human Aortic Endothelial Cells

Resistin may be an important link between obesity and diabetes. Recent studies have suggested an association between resistin and atherogenic processes. In addition, CCL19 is highly expressed in human atherosclerotic lesions. The interplays among resistin, CCL19, and shear stress in regulating vascu...

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Veröffentlicht in:	Journal of cellular physiology 2015-09, Vol.230 (9), p.2120-2127
Hauptverfasser:	Yu, Hong-Ren, Sung, Mao-Ling, Kuo, Hsing-Chun, Lin, Chi-Hui, Chen, Cheng-Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Aorta Aorta - metabolism Aorta - pathology Arteriosclerosis Atherosclerosis Atherosclerosis - genetics CCL19 protein Chemokine CCL19 - antagonists & inhibitors Chemokine CCL19 - biosynthesis Chemokine CCL19 - genetics Chromatin Deoxyribonucleic acid Diabetes mellitus DNA DNA structure Endothelial cells Endothelial Cells - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Enzyme-linked immunosorbent assay Gene Expression Regulation - drug effects Humans Immunoprecipitation Lesions Mechanical stimuli Molecular modelling NF-κB protein Resistin - administration & dosage Ribonucleic acid RNA Shear stress siRNA Stress, Mechanical TLR4 protein Toll-Like Receptor 4 - biosynthesis Toll-Like Receptor 4 - genetics Toll-like receptors
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