Leptin Affects Prolactin Action on Milk Protein and Fat Synthesis in the Bovine Mammary Gland
Leptin, a protein hormone produced and secreted predominantly by white adipose tissue, has a critical role in the regulation and coordination of energy metabolism. Identification of leptin in the milk of several mammals, including humans, led us to investigate its presence and regulatory effect in t...
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| Veröffentlicht in: | Journal of dairy science 2004-09, Vol.87 (9), p.2941-2946 |
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| description | Leptin, a protein hormone produced and secreted predominantly by white adipose tissue, has a critical role in the regulation and coordination of energy metabolism. Identification of leptin in the milk of several mammals, including humans, led us to investigate its presence and regulatory effect in the cow mammary gland. The expression of leptin receptor in tissue culture of lactating mammary gland was augmented approximately 25 times by prolactin, but had no effect on virgin calf mammary tissue. Expression of leptin in tissue culture from mammary glands of lactating cows was enhanced 2.2-fold by prolactin. No effect of prolactin on leptin and leptin receptor expression was found in mammary gland tissue culture from calves. Leptin-enhanced fatty acid synthesis in the presence of prolactin, but had no effect without presence of prolactin. A similar pattern was found in the expression of α-casein and β-lactoglobulin in mammary gland explants from a lactating cow. Our findings indicate that leptin plays an important role in mammary gland lactogenesis, and that the expression of leptin requires the presence of prolactin. |
| doi_str_mv | 10.3168/jds.S0022-0302(04)73425-6 |
| format | Article |
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Identification of leptin in the milk of several mammals, including humans, led us to investigate its presence and regulatory effect in the cow mammary gland. The expression of leptin receptor in tissue culture of lactating mammary gland was augmented approximately 25 times by prolactin, but had no effect on virgin calf mammary tissue. Expression of leptin in tissue culture from mammary glands of lactating cows was enhanced 2.2-fold by prolactin. No effect of prolactin on leptin and leptin receptor expression was found in mammary gland tissue culture from calves. Leptin-enhanced fatty acid synthesis in the presence of prolactin, but had no effect without presence of prolactin. A similar pattern was found in the expression of α-casein and β-lactoglobulin in mammary gland explants from a lactating cow. Our findings indicate that leptin plays an important role in mammary gland lactogenesis, and that the expression of leptin requires the presence of prolactin.</description><identifier>ISSN: 0022-0302</identifier><identifier>EISSN: 1525-3198</identifier><identifier>DOI: 10.3168/jds.S0022-0302(04)73425-6</identifier><identifier>PMID: 15375055</identifier><identifier>CODEN: JDSCAE</identifier><language>eng</language><publisher>Savoy, IL: Elsevier Inc</publisher><subject>Animal productions ; Animals ; Biological and medical sciences ; bovine mammary gland ; calves ; Caseins - genetics ; Cattle - metabolism ; Culture Techniques ; dairy cows ; fat synthesis ; Fatty Acids - biosynthesis ; Female ; Food industries ; Fundamental and applied biological sciences. Psychology ; Gene Expression - drug effects ; gene expression regulation ; hormone receptors ; Lactation ; Lactoglobulins - genetics ; leptin ; Leptin - genetics ; Leptin - physiology ; Lipids - biosynthesis ; mammary glands ; Mammary Glands, Animal - drug effects ; Mammary Glands, Animal - metabolism ; Milk and cheese industries. Ice creams ; Milk Proteins - biosynthesis ; milk synthesis ; prolactin ; Prolactin - pharmacology ; Receptors, Cell Surface - genetics ; Receptors, Leptin ; RNA, Messenger - analysis ; Terrestrial animal productions ; Vertebrates</subject><ispartof>Journal of dairy science, 2004-09, Vol.87 (9), p.2941-2946</ispartof><rights>2004 American Dairy Science Association</rights><rights>2004 INIST-CNRS</rights><rights>Copyright American Dairy Science Association Sep 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-ffe830685fed0f46ea5bf2ebef0311130ab0d777373f60a5753b45636bb0f84a3</citedby><cites>FETCH-LOGICAL-c571t-ffe830685fed0f46ea5bf2ebef0311130ab0d777373f60a5753b45636bb0f84a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3168/jds.S0022-0302(04)73425-6$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16076711$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15375055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feuermann, Y.</creatorcontrib><creatorcontrib>Mabjeesh, S.J.</creatorcontrib><creatorcontrib>Shamay, A.</creatorcontrib><title>Leptin Affects Prolactin Action on Milk Protein and Fat Synthesis in the Bovine Mammary Gland</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>Leptin, a protein hormone produced and secreted predominantly by white adipose tissue, has a critical role in the regulation and coordination of energy metabolism. Identification of leptin in the milk of several mammals, including humans, led us to investigate its presence and regulatory effect in the cow mammary gland. The expression of leptin receptor in tissue culture of lactating mammary gland was augmented approximately 25 times by prolactin, but had no effect on virgin calf mammary tissue. Expression of leptin in tissue culture from mammary glands of lactating cows was enhanced 2.2-fold by prolactin. No effect of prolactin on leptin and leptin receptor expression was found in mammary gland tissue culture from calves. Leptin-enhanced fatty acid synthesis in the presence of prolactin, but had no effect without presence of prolactin. A similar pattern was found in the expression of α-casein and β-lactoglobulin in mammary gland explants from a lactating cow. Our findings indicate that leptin plays an important role in mammary gland lactogenesis, and that the expression of leptin requires the presence of prolactin.</description><subject>Animal productions</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>bovine mammary gland</subject><subject>calves</subject><subject>Caseins - genetics</subject><subject>Cattle - metabolism</subject><subject>Culture Techniques</subject><subject>dairy cows</subject><subject>fat synthesis</subject><subject>Fatty Acids - biosynthesis</subject><subject>Female</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression - drug effects</subject><subject>gene expression regulation</subject><subject>hormone receptors</subject><subject>Lactation</subject><subject>Lactoglobulins - genetics</subject><subject>leptin</subject><subject>Leptin - genetics</subject><subject>Leptin - physiology</subject><subject>Lipids - biosynthesis</subject><subject>mammary glands</subject><subject>Mammary Glands, Animal - drug effects</subject><subject>Mammary Glands, Animal - metabolism</subject><subject>Milk and cheese industries. Ice creams</subject><subject>Milk Proteins - biosynthesis</subject><subject>milk synthesis</subject><subject>prolactin</subject><subject>Prolactin - pharmacology</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Leptin</subject><subject>RNA, Messenger - analysis</subject><subject>Terrestrial animal productions</subject><subject>Vertebrates</subject><issn>0022-0302</issn><issn>1525-3198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkFFv0zAQxy0EYqXwFcAgDcFDxjmO7eRxq9hA6sSkbo_Ichx7dUmTYqdD-_Zcmoq9Iln2-fy7-_v-hLxncMaZLL9smnS2AsjzDDjkn6D4rHiRi0w-IzMmMOCsKp-T2T_khLxKaYNXloN4SU6Y4EqAEDPyc-l2Q-jouffODonexL419pDBve8oruvQ_hofBodp0zX00gx09dgNa5dCopjEiF70D6Fz9NpstyY-0qsWydfkhTdtcm-O55zcXX69XXzLlj-uvi_Ol5kVig0ZapccZCm8a8AX0hlR-9zVzgNnjHEwNTRKKa64l2CEErwuhOSyrsGXheFz8mHqu4v9771Lg970-9ihpGaVKFlZKolQNUE29ilF5_UuhvGvmoEefdXoqz74qkfTNBT64Ksea98eBfb11jVPlUcjETg9AiZZ0_poOhvSEydBSYWjzMnHiVuH-_WfEJ1OW9O22JaN8qXSlc6rYgTfTaA3vTb3EZvdrXJAM6CSSrEKicVEOHT2Ibiokw2us67BtnbQTR_-Y7K_h4SsuQ</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Feuermann, Y.</creator><creator>Mabjeesh, S.J.</creator><creator>Shamay, A.</creator><general>Elsevier Inc</general><general>Am Dairy Sci Assoc</general><general>American Dairy Science Association</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>S0X</scope></search><sort><creationdate>20040901</creationdate><title>Leptin Affects Prolactin Action on Milk Protein and Fat Synthesis in the Bovine Mammary Gland</title><author>Feuermann, Y. ; Mabjeesh, S.J. ; Shamay, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-ffe830685fed0f46ea5bf2ebef0311130ab0d777373f60a5753b45636bb0f84a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animal productions</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>bovine mammary gland</topic><topic>calves</topic><topic>Caseins - genetics</topic><topic>Cattle - metabolism</topic><topic>Culture Techniques</topic><topic>dairy cows</topic><topic>fat synthesis</topic><topic>Fatty Acids - biosynthesis</topic><topic>Female</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression - drug effects</topic><topic>gene expression regulation</topic><topic>hormone receptors</topic><topic>Lactation</topic><topic>Lactoglobulins - genetics</topic><topic>leptin</topic><topic>Leptin - genetics</topic><topic>Leptin - physiology</topic><topic>Lipids - biosynthesis</topic><topic>mammary glands</topic><topic>Mammary Glands, Animal - drug effects</topic><topic>Mammary Glands, Animal - metabolism</topic><topic>Milk and cheese industries. Ice creams</topic><topic>Milk Proteins - biosynthesis</topic><topic>milk synthesis</topic><topic>prolactin</topic><topic>Prolactin - pharmacology</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Leptin</topic><topic>RNA, Messenger - analysis</topic><topic>Terrestrial animal productions</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feuermann, Y.</creatorcontrib><creatorcontrib>Mabjeesh, S.J.</creatorcontrib><creatorcontrib>Shamay, A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>SIRS Editorial</collection><jtitle>Journal of dairy science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feuermann, Y.</au><au>Mabjeesh, S.J.</au><au>Shamay, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin Affects Prolactin Action on Milk Protein and Fat Synthesis in the Bovine Mammary Gland</atitle><jtitle>Journal of dairy science</jtitle><addtitle>J Dairy Sci</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>87</volume><issue>9</issue><spage>2941</spage><epage>2946</epage><pages>2941-2946</pages><issn>0022-0302</issn><eissn>1525-3198</eissn><coden>JDSCAE</coden><abstract>Leptin, a protein hormone produced and secreted predominantly by white adipose tissue, has a critical role in the regulation and coordination of energy metabolism. Identification of leptin in the milk of several mammals, including humans, led us to investigate its presence and regulatory effect in the cow mammary gland. The expression of leptin receptor in tissue culture of lactating mammary gland was augmented approximately 25 times by prolactin, but had no effect on virgin calf mammary tissue. Expression of leptin in tissue culture from mammary glands of lactating cows was enhanced 2.2-fold by prolactin. No effect of prolactin on leptin and leptin receptor expression was found in mammary gland tissue culture from calves. Leptin-enhanced fatty acid synthesis in the presence of prolactin, but had no effect without presence of prolactin. A similar pattern was found in the expression of α-casein and β-lactoglobulin in mammary gland explants from a lactating cow. Our findings indicate that leptin plays an important role in mammary gland lactogenesis, and that the expression of leptin requires the presence of prolactin.</abstract><cop>Savoy, IL</cop><pub>Elsevier Inc</pub><pmid>15375055</pmid><doi>10.3168/jds.S0022-0302(04)73425-6</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal productions Animals Biological and medical sciences bovine mammary gland calves Caseins - genetics Cattle - metabolism Culture Techniques dairy cows fat synthesis Fatty Acids - biosynthesis Female Food industries Fundamental and applied biological sciences. Psychology Gene Expression - drug effects gene expression regulation hormone receptors Lactation Lactoglobulins - genetics leptin Leptin - genetics Leptin - physiology Lipids - biosynthesis mammary glands Mammary Glands, Animal - drug effects Mammary Glands, Animal - metabolism Milk and cheese industries. Ice creams Milk Proteins - biosynthesis milk synthesis prolactin Prolactin - pharmacology Receptors, Cell Surface - genetics Receptors, Leptin RNA, Messenger - analysis Terrestrial animal productions Vertebrates |
| title | Leptin Affects Prolactin Action on Milk Protein and Fat Synthesis in the Bovine Mammary Gland |
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