A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism
N-myc downstream-regulated gene 1 (NDRG1) is known as tumor/metastasis suppressor in a variety of cancers including pancreas, being involved in angiogenesis, cancer growth and metastasis. However, the precise molecular mechanism how NDRG1 exerts its inhibitory function in pancreatic cancer remains u...
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| Veröffentlicht in: | International journal of oncology 2017-05, Vol.50 (5), p.1792-1800 |
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| creator | Liu, Wensheng Zhang, Bo Hu, Qiangsheng Qin, Yi Xu, Wenyan Shi, Si Liang, Chen Meng, Qingcai Xiang, Jinfeng Liang, Dingkong Ji, Shunrong Liu, Jiang Hu, Pengfei Liu, Liang Liu, Chen Long, Jiang Ni, Quanxing Yu, Xianjun Xu, Jin |
| description | N-myc downstream-regulated gene 1 (NDRG1) is known as tumor/metastasis suppressor in a variety of cancers including pancreas, being involved in angiogenesis, cancer growth and metastasis. However, the precise molecular mechanism how NDRG1 exerts its inhibitory function in pancreatic cancer remains unclear. In this investigation, we demonstrated that K-Ras plays a vital role in modulating NDRG1 protein level in PDAC cancer cells in vitro, which is mediated through ERK signaling. Noteworthy, K-Ras downstream Akt/mTOR signaling is inhibited upon NDRG1 overexpression, resulting in decease of HIF1α level. Moreover, NDRG1 has a unique role in modulating cancer metabolism of pancreatic ductal adenocarcinoma (PDAC). The mechanism accounting for NDRG1 in modulating aerobic glycolysis, at least partly, relied on its regulation of glycolysis genes including GLUT1, HK2, LDHA and PDK1. Additionally, NDRG1 is shown to suppress the activity of HIF1α, which is responsible for regulation of glycolysis enzymes. The current study is the first to elucidate a unique facet of the potent tumor/metastasis suppressor NDRG1 in the regulation of PDAC glycolysis, leading to important insights into the mechanism by which NDRG1 exert inhibitory function in PDAC. |
| doi_str_mv | 10.3892/ijo.2017.3938 |
| format | Article |
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However, the precise molecular mechanism how NDRG1 exerts its inhibitory function in pancreatic cancer remains unclear. In this investigation, we demonstrated that K-Ras plays a vital role in modulating NDRG1 protein level in PDAC cancer cells in vitro, which is mediated through ERK signaling. Noteworthy, K-Ras downstream Akt/mTOR signaling is inhibited upon NDRG1 overexpression, resulting in decease of HIF1α level. Moreover, NDRG1 has a unique role in modulating cancer metabolism of pancreatic ductal adenocarcinoma (PDAC). The mechanism accounting for NDRG1 in modulating aerobic glycolysis, at least partly, relied on its regulation of glycolysis genes including GLUT1, HK2, LDHA and PDK1. Additionally, NDRG1 is shown to suppress the activity of HIF1α, which is responsible for regulation of glycolysis enzymes. The current study is the first to elucidate a unique facet of the potent tumor/metastasis suppressor NDRG1 in the regulation of PDAC glycolysis, leading to important insights into the mechanism by which NDRG1 exert inhibitory function in PDAC.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2017.3938</identifier><identifier>PMID: 28350132</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - pathology ; Angiogenesis ; Biology ; Carcinoma, Pancreatic Ductal - genetics ; Carcinoma, Pancreatic Ductal - pathology ; Care and treatment ; Cell Cycle Proteins - biosynthesis ; Cell Cycle Proteins - genetics ; Cell growth ; Cell Line, Tumor ; Development and progression ; Enzymes ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Genes ; Genes, Tumor Suppressor ; Genetic aspects ; Glycolysis - genetics ; Health aspects ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit - genetics ; Intracellular Signaling Peptides and Proteins - biosynthesis ; Intracellular Signaling Peptides and Proteins - genetics ; Kinases ; Male ; MAP Kinase Signaling System - genetics ; Medical prognosis ; Metabolism ; Metastasis ; Neoplasm Metastasis ; Neoplasm Proteins - genetics ; Pancreatic cancer ; Proteins ; Tumor suppressor genes</subject><ispartof>International journal of oncology, 2017-05, Vol.50 (5), p.1792-1800</ispartof><rights>COPYRIGHT 2017 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-de08f19a4b2fb70f4ea782bd6e1971a1e140348720ce4b3db1f60fa8babfd8773</citedby><cites>FETCH-LOGICAL-c458t-de08f19a4b2fb70f4ea782bd6e1971a1e140348720ce4b3db1f60fa8babfd8773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28350132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Wensheng</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Hu, Qiangsheng</creatorcontrib><creatorcontrib>Qin, Yi</creatorcontrib><creatorcontrib>Xu, Wenyan</creatorcontrib><creatorcontrib>Shi, Si</creatorcontrib><creatorcontrib>Liang, Chen</creatorcontrib><creatorcontrib>Meng, Qingcai</creatorcontrib><creatorcontrib>Xiang, Jinfeng</creatorcontrib><creatorcontrib>Liang, Dingkong</creatorcontrib><creatorcontrib>Ji, Shunrong</creatorcontrib><creatorcontrib>Liu, Jiang</creatorcontrib><creatorcontrib>Hu, Pengfei</creatorcontrib><creatorcontrib>Liu, Liang</creatorcontrib><creatorcontrib>Liu, Chen</creatorcontrib><creatorcontrib>Long, Jiang</creatorcontrib><creatorcontrib>Ni, Quanxing</creatorcontrib><creatorcontrib>Yu, Xianjun</creatorcontrib><creatorcontrib>Xu, Jin</creatorcontrib><title>A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>N-myc downstream-regulated gene 1 (NDRG1) is known as tumor/metastasis suppressor in a variety of cancers including pancreas, being involved in angiogenesis, cancer growth and metastasis. However, the precise molecular mechanism how NDRG1 exerts its inhibitory function in pancreatic cancer remains unclear. In this investigation, we demonstrated that K-Ras plays a vital role in modulating NDRG1 protein level in PDAC cancer cells in vitro, which is mediated through ERK signaling. Noteworthy, K-Ras downstream Akt/mTOR signaling is inhibited upon NDRG1 overexpression, resulting in decease of HIF1α level. Moreover, NDRG1 has a unique role in modulating cancer metabolism of pancreatic ductal adenocarcinoma (PDAC). The mechanism accounting for NDRG1 in modulating aerobic glycolysis, at least partly, relied on its regulation of glycolysis genes including GLUT1, HK2, LDHA and PDK1. Additionally, NDRG1 is shown to suppress the activity of HIF1α, which is responsible for regulation of glycolysis enzymes. The current study is the first to elucidate a unique facet of the potent tumor/metastasis suppressor NDRG1 in the regulation of PDAC glycolysis, leading to important insights into the mechanism by which NDRG1 exert inhibitory function in PDAC.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - pathology</subject><subject>Angiogenesis</subject><subject>Biology</subject><subject>Carcinoma, Pancreatic Ductal - genetics</subject><subject>Carcinoma, Pancreatic Ductal - pathology</subject><subject>Care and treatment</subject><subject>Cell Cycle Proteins - biosynthesis</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Development and progression</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes</subject><subject>Genes, Tumor Suppressor</subject><subject>Genetic aspects</subject><subject>Glycolysis - genetics</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - biosynthesis</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Kinases</subject><subject>Male</subject><subject>MAP Kinase Signaling System - genetics</subject><subject>Medical prognosis</subject><subject>Metabolism</subject><subject>Metastasis</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Pancreatic cancer</subject><subject>Proteins</subject><subject>Tumor suppressor genes</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkctrFTEUh4MotlaXbiUguJtrXjNJ3F1arUJR8LE1JJmTNpeZyZjMIPe_N0ProyBZnEP4fjnkfAg9p2THlWav4yHtGKFyxzVXD9AplZo2TDD-sPaE6qYTXJ-gJ6UcCGFtS-hjdMIUrw1np-j7Hk_wEwfrYcEp4I8Xny8pjhOe7eQz2CV63K9-sQO2PUzJ2-zjlEb7Bn9Z5zlDKTFNW_J6OPo0HLfACIt1aYhlfIoeBTsUeHZXz9C3d2-_nr9vrj5dfjjfXzVetGppeiAqUG2FY8FJEgRYqZjrO6BaUkuBCsKFkox4EI73joaOBKucdaFXUvIz9PL23TmnHyuUxRzSmqc60lDdyq7lrFN_qWs7gIlTSEu2fozFm73QXIu2k7RSu_9Q9fQwRp8mCLHe3wu8-idwA3ZYbkoa1qVuptwHm1vQ51RKhmDmHEebj4YSs9k01abZbJrNZuVf3P1qdSP0f-jf-vgvG6OYxQ</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Liu, Wensheng</creator><creator>Zhang, Bo</creator><creator>Hu, Qiangsheng</creator><creator>Qin, Yi</creator><creator>Xu, Wenyan</creator><creator>Shi, Si</creator><creator>Liang, Chen</creator><creator>Meng, Qingcai</creator><creator>Xiang, Jinfeng</creator><creator>Liang, Dingkong</creator><creator>Ji, Shunrong</creator><creator>Liu, Jiang</creator><creator>Hu, Pengfei</creator><creator>Liu, Liang</creator><creator>Liu, Chen</creator><creator>Long, Jiang</creator><creator>Ni, Quanxing</creator><creator>Yu, Xianjun</creator><creator>Xu, Jin</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170501</creationdate><title>A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism</title><author>Liu, Wensheng ; Zhang, Bo ; Hu, Qiangsheng ; Qin, Yi ; Xu, Wenyan ; Shi, Si ; Liang, Chen ; Meng, Qingcai ; Xiang, Jinfeng ; Liang, Dingkong ; Ji, Shunrong ; Liu, Jiang ; Hu, Pengfei ; Liu, Liang ; Liu, Chen ; Long, Jiang ; Ni, Quanxing ; Yu, Xianjun ; Xu, Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-de08f19a4b2fb70f4ea782bd6e1971a1e140348720ce4b3db1f60fa8babfd8773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - pathology</topic><topic>Angiogenesis</topic><topic>Biology</topic><topic>Carcinoma, Pancreatic Ductal - genetics</topic><topic>Carcinoma, Pancreatic Ductal - pathology</topic><topic>Care and treatment</topic><topic>Cell Cycle Proteins - biosynthesis</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Development and progression</topic><topic>Enzymes</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genes</topic><topic>Genes, Tumor Suppressor</topic><topic>Genetic aspects</topic><topic>Glycolysis - genetics</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - genetics</topic><topic>Intracellular Signaling Peptides and Proteins - biosynthesis</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Kinases</topic><topic>Male</topic><topic>MAP Kinase Signaling System - genetics</topic><topic>Medical prognosis</topic><topic>Metabolism</topic><topic>Metastasis</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Proteins - genetics</topic><topic>Pancreatic cancer</topic><topic>Proteins</topic><topic>Tumor suppressor genes</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Wensheng</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Hu, Qiangsheng</creatorcontrib><creatorcontrib>Qin, Yi</creatorcontrib><creatorcontrib>Xu, Wenyan</creatorcontrib><creatorcontrib>Shi, Si</creatorcontrib><creatorcontrib>Liang, Chen</creatorcontrib><creatorcontrib>Meng, Qingcai</creatorcontrib><creatorcontrib>Xiang, Jinfeng</creatorcontrib><creatorcontrib>Liang, Dingkong</creatorcontrib><creatorcontrib>Ji, Shunrong</creatorcontrib><creatorcontrib>Liu, Jiang</creatorcontrib><creatorcontrib>Hu, Pengfei</creatorcontrib><creatorcontrib>Liu, Liang</creatorcontrib><creatorcontrib>Liu, Chen</creatorcontrib><creatorcontrib>Long, Jiang</creatorcontrib><creatorcontrib>Ni, Quanxing</creatorcontrib><creatorcontrib>Yu, Xianjun</creatorcontrib><creatorcontrib>Xu, Jin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Wensheng</au><au>Zhang, Bo</au><au>Hu, Qiangsheng</au><au>Qin, Yi</au><au>Xu, Wenyan</au><au>Shi, Si</au><au>Liang, Chen</au><au>Meng, Qingcai</au><au>Xiang, Jinfeng</au><au>Liang, Dingkong</au><au>Ji, Shunrong</au><au>Liu, Jiang</au><au>Hu, Pengfei</au><au>Liu, Liang</au><au>Liu, Chen</au><au>Long, Jiang</au><au>Ni, Quanxing</au><au>Yu, Xianjun</au><au>Xu, Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism</atitle><jtitle>International journal of oncology</jtitle><addtitle>Int J Oncol</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>50</volume><issue>5</issue><spage>1792</spage><epage>1800</epage><pages>1792-1800</pages><issn>1019-6439</issn><eissn>1791-2423</eissn><abstract>N-myc downstream-regulated gene 1 (NDRG1) is known as tumor/metastasis suppressor in a variety of cancers including pancreas, being involved in angiogenesis, cancer growth and metastasis. However, the precise molecular mechanism how NDRG1 exerts its inhibitory function in pancreatic cancer remains unclear. In this investigation, we demonstrated that K-Ras plays a vital role in modulating NDRG1 protein level in PDAC cancer cells in vitro, which is mediated through ERK signaling. Noteworthy, K-Ras downstream Akt/mTOR signaling is inhibited upon NDRG1 overexpression, resulting in decease of HIF1α level. Moreover, NDRG1 has a unique role in modulating cancer metabolism of pancreatic ductal adenocarcinoma (PDAC). The mechanism accounting for NDRG1 in modulating aerobic glycolysis, at least partly, relied on its regulation of glycolysis genes including GLUT1, HK2, LDHA and PDK1. Additionally, NDRG1 is shown to suppress the activity of HIF1α, which is responsible for regulation of glycolysis enzymes. The current study is the first to elucidate a unique facet of the potent tumor/metastasis suppressor NDRG1 in the regulation of PDAC glycolysis, leading to important insights into the mechanism by which NDRG1 exert inhibitory function in PDAC.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>28350132</pmid><doi>10.3892/ijo.2017.3938</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of oncology, 2017-05, Vol.50 (5), p.1792-1800 |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - genetics Adenocarcinoma - pathology Angiogenesis Biology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Care and treatment Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - genetics Cell growth Cell Line, Tumor Development and progression Enzymes Female Gene expression Gene Expression Regulation, Neoplastic Genes Genes, Tumor Suppressor Genetic aspects Glycolysis - genetics Health aspects Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Intracellular Signaling Peptides and Proteins - biosynthesis Intracellular Signaling Peptides and Proteins - genetics Kinases Male MAP Kinase Signaling System - genetics Medical prognosis Metabolism Metastasis Neoplasm Metastasis Neoplasm Proteins - genetics Pancreatic cancer Proteins Tumor suppressor genes |
| title | A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism |
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