Substrate stiffness affects epithelial-mesenchymal transition of cervical cancer cells through miR-106b and its target protein DAB2

The effects of different substrate stiffness were investigated on epithelial-mesenchymal transition (EMT) of cervical cancer cell lines and the role of miR-106b and its target protein DAB2 therein. Cervical cancer cell lines HeLa and SiHa were cultured on artificial substrates with different stiffne...

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Veröffentlicht in:	International journal of oncology 2017-06, Vol.50 (6), p.2033-2042
Hauptverfasser:	Piao, Jinlan, You, Ke, Guo, Yanli, Zhang, Youyi, Li, Zijian, Geng, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - antagonists & inhibitors Adaptor Proteins, Signal Transducing - genetics Breast cancer Cancer cells Care and treatment Cell Movement - genetics Cell Proliferation - genetics Cervical cancer Developing countries Epithelial-Mesenchymal Transition - genetics Extracellular matrix Female Fibroblasts Gene Expression Regulation, Neoplastic Gene Knockdown Techniques HeLa Cells Human papillomavirus Humans LDCs Mechanical properties Metastasis MicroRNA MicroRNAs MicroRNAs - genetics Proteins Stem cells Studies Substrate Specificity Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - genetics Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology Womens health
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