Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling

Resveratrol is known to be an effective chemo-preventive phytochemical against multiple tumor cells. However, the increasing drug resistance avoids the cancer treatment in oral cavity cancer. In this study, we investigated the oral antitumor activity of resveratrol and its mechanism in cisplatin-res...

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Veröffentlicht in:	International journal of oncology 2017-03, Vol.50 (3), p.873-882
Hauptverfasser:	Chang, Chao-Hsiang, Lee, Chao-Ying, Lu, Chi-Cheng, Tsai, Fuu-Jen, Hsu, Yuan-Man, Tsao, Je-Wei, Juan, Yu-Ning, Chiu, Hong-Yi, Yang, Jai-Sing, Wang, Ching-Chiung
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology AMP-Activated Protein Kinases - metabolism Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Autophagy-Related Protein 12 - genetics Autophagy-Related Protein 5 - genetics Beclin-1 - genetics Cancer therapies Care and treatment Caspase 3 - metabolism Caspase 9 - metabolism Cell Line, Tumor Cellular signal transduction Chemotherapy Cisplatin - pharmacology Cytochrome Cytoplasm Deoxyribonucleic acid Development and progression DNA DNA Fragmentation - drug effects Drug Resistance, Neoplasm Health aspects Humans Immunoglobulins Kinases Microtubule-Associated Proteins - genetics Mitochondria Morphology Mouth cancer Mouth Neoplasms - pathology Oral cancer Penicillin Phosphorylation - drug effects Proteins Proto-Oncogene Proteins c-akt - metabolism Resveratrol RNA, Messenger - genetics Rodents Signal Transduction - drug effects Stilbenes - pharmacology TOR Serine-Threonine Kinases - metabolism
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