Cordycepin induces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS
Medicinal plants are affluent sources of several effectual natural drugs. Among them cordycepin which is extracted from Cordyceps militaris is a hopeful chemotherapy agent due to its extensive anti-inflammatory, anti-proliferative, antioxidant, and antitumor characteristics. This study investigated...
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| Veröffentlicht in: | International journal of oncology 2017-03, Vol.50 (3), p.911-919 |
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| container_title | International journal of oncology |
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| creator | Nasser, Moussa Ide Masood, Muqaddas Wei, Wei Li, Xiaochun Zhou, Yifa Liu, Bao Li, Jiang Li, Xiaomeng |
| description | Medicinal plants are affluent sources of several effectual natural drugs. Among them cordycepin which is extracted from Cordyceps militaris is a hopeful chemotherapy agent due to its extensive anti-inflammatory, anti-proliferative, antioxidant, and antitumor characteristics. This study investigated the efficacy of cordycepin in the context of human gastric cancer SGC‑7901 and searched for the cell death procedure. Cordycepin incorporates mitochondrial-mediated apoptosis in SGC‑7901 cells with the help of regulating mitochondrial extrinsic pathways by inhibition of A3AR and drive activation of DR3, which promote the activation of PI3K/Akt protein expression as well as collapse of mitochondrial membrane potential (MMP). In addition, phosphorylation of PI3K/Akt and DNA damage by cordycepin induced the production of reactive oxygen species (ROS), and mediates SGC‑7901 cell cycle cessation at S phase. Collectively, this study suggests that cordycepin might be effective as a modern chemotherapy drug for gastric cancer. |
| doi_str_mv | 10.3892/ijo.2017.3862 |
| format | Article |
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Among them cordycepin which is extracted from Cordyceps militaris is a hopeful chemotherapy agent due to its extensive anti-inflammatory, anti-proliferative, antioxidant, and antitumor characteristics. This study investigated the efficacy of cordycepin in the context of human gastric cancer SGC‑7901 and searched for the cell death procedure. Cordycepin incorporates mitochondrial-mediated apoptosis in SGC‑7901 cells with the help of regulating mitochondrial extrinsic pathways by inhibition of A3AR and drive activation of DR3, which promote the activation of PI3K/Akt protein expression as well as collapse of mitochondrial membrane potential (MMP). In addition, phosphorylation of PI3K/Akt and DNA damage by cordycepin induced the production of reactive oxygen species (ROS), and mediates SGC‑7901 cell cycle cessation at S phase. Collectively, this study suggests that cordycepin might be effective as a modern chemotherapy drug for gastric cancer.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2017.3862</identifier><identifier>PMID: 28197639</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Adenosine ; Anti-Inflammatory Agents - pharmacology ; Antineoplastic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Biotechnology ; Cancer therapies ; Care and treatment ; Cell cycle ; Cell growth ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chemotherapy ; Cordyceps ; Deoxyadenosines - pharmacology ; Gastric cancer ; Health aspects ; Humans ; Immunoglobulins ; Kinases ; Materia medica, Vegetable ; Membrane Potential, Mitochondrial - drug effects ; Metabolism ; Mitochondria - metabolism ; Phosphatidylinositol 3-Kinases - metabolism ; Phosphorylation ; Phosphorylation - drug effects ; Plant extracts ; Protein expression ; Proteins ; Proto-Oncogene Proteins c-akt - metabolism ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Receptors, Tumor Necrosis Factor, Member 25 - metabolism ; S Phase Cell Cycle Checkpoints - drug effects ; Signal Transduction - drug effects ; Stomach cancer ; Stomach Neoplasms - drug therapy ; Stomach Neoplasms - pathology ; Studies</subject><ispartof>International journal of oncology, 2017-03, Vol.50 (3), p.911-919</ispartof><rights>COPYRIGHT 2017 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-20c26e7fdb384da943425b2730e7a6c5324d057f0cf47ef1a9bcdbe85dc3c2803</citedby><cites>FETCH-LOGICAL-c524t-20c26e7fdb384da943425b2730e7a6c5324d057f0cf47ef1a9bcdbe85dc3c2803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28197639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nasser, Moussa Ide</creatorcontrib><creatorcontrib>Masood, Muqaddas</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Li, Xiaochun</creatorcontrib><creatorcontrib>Zhou, Yifa</creatorcontrib><creatorcontrib>Liu, Bao</creatorcontrib><creatorcontrib>Li, Jiang</creatorcontrib><creatorcontrib>Li, Xiaomeng</creatorcontrib><title>Cordycepin induces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>Medicinal plants are affluent sources of several effectual natural drugs. Among them cordycepin which is extracted from Cordyceps militaris is a hopeful chemotherapy agent due to its extensive anti-inflammatory, anti-proliferative, antioxidant, and antitumor characteristics. This study investigated the efficacy of cordycepin in the context of human gastric cancer SGC‑7901 and searched for the cell death procedure. Cordycepin incorporates mitochondrial-mediated apoptosis in SGC‑7901 cells with the help of regulating mitochondrial extrinsic pathways by inhibition of A3AR and drive activation of DR3, which promote the activation of PI3K/Akt protein expression as well as collapse of mitochondrial membrane potential (MMP). In addition, phosphorylation of PI3K/Akt and DNA damage by cordycepin induced the production of reactive oxygen species (ROS), and mediates SGC‑7901 cell cycle cessation at S phase. Collectively, this study suggests that cordycepin might be effective as a modern chemotherapy drug for gastric cancer.</description><subject>Adenosine</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biotechnology</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Chemotherapy</subject><subject>Cordyceps</subject><subject>Deoxyadenosines - pharmacology</subject><subject>Gastric cancer</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Kinases</subject><subject>Materia medica, Vegetable</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Metabolism</subject><subject>Mitochondria - metabolism</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Phosphorylation</subject><subject>Phosphorylation - drug effects</subject><subject>Plant extracts</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Receptors, Tumor Necrosis Factor, Member 25 - metabolism</subject><subject>S Phase Cell Cycle Checkpoints - drug effects</subject><subject>Signal Transduction - drug effects</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - drug therapy</subject><subject>Stomach Neoplasms - pathology</subject><subject>Studies</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkVtrFDEUgAex2Fp99FUCgm-zzW0mk8dl0VostFh9DplcdrLOJGOSAfdF_Av-RX-JWXrRgoRDkpPvJJx8VfUKwRXpOD5zu7DCELGya_GT6gQxjmpMMXla1hDxuqWEH1fPU9pBiJsGomfVMe4QZy3hJ9WPTYh6r8zsPHBeL8okIOcw55BcKhlwc775_fMX4xABZcYxgTzEsGwHMLkc1BC8jk6OwHzP0fnkFJiHkErE_SizCx4EC64vyMez9dcM-j3YGm9iOfFb8Onq5kV1ZOWYzMu7-bT68v7d582H-vLq_GKzvqxVg2muMVS4NczqnnRUS04JxU2PGYGGyVY1BFMNG2ahspQZiyTvle5N12hFFO4gOa3e3N47x_BtMSmLXViiL08KxBvWUo4J-Utt5WiE8zbkKNXkkhJryhFqGOzaQq3-Q5WhzeRU8Ma6kn9U8PafgsHIMQ8pjMvhe9JjsL4FVQwpRWPFHN0k414gKA62RbEtDrbFwXbhX991tfST0Q_0vV7yB4T7pQ8</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Nasser, Moussa Ide</creator><creator>Masood, Muqaddas</creator><creator>Wei, Wei</creator><creator>Li, Xiaochun</creator><creator>Zhou, Yifa</creator><creator>Liu, Bao</creator><creator>Li, Jiang</creator><creator>Li, Xiaomeng</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170301</creationdate><title>Cordycepin induces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS</title><author>Nasser, Moussa Ide ; 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Among them cordycepin which is extracted from Cordyceps militaris is a hopeful chemotherapy agent due to its extensive anti-inflammatory, anti-proliferative, antioxidant, and antitumor characteristics. This study investigated the efficacy of cordycepin in the context of human gastric cancer SGC‑7901 and searched for the cell death procedure. Cordycepin incorporates mitochondrial-mediated apoptosis in SGC‑7901 cells with the help of regulating mitochondrial extrinsic pathways by inhibition of A3AR and drive activation of DR3, which promote the activation of PI3K/Akt protein expression as well as collapse of mitochondrial membrane potential (MMP). In addition, phosphorylation of PI3K/Akt and DNA damage by cordycepin induced the production of reactive oxygen species (ROS), and mediates SGC‑7901 cell cycle cessation at S phase. Collectively, this study suggests that cordycepin might be effective as a modern chemotherapy drug for gastric cancer.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>28197639</pmid><doi>10.3892/ijo.2017.3862</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of oncology, 2017-03, Vol.50 (3), p.911-919 |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adenosine Anti-Inflammatory Agents - pharmacology Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biotechnology Cancer therapies Care and treatment Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cordyceps Deoxyadenosines - pharmacology Gastric cancer Health aspects Humans Immunoglobulins Kinases Materia medica, Vegetable Membrane Potential, Mitochondrial - drug effects Metabolism Mitochondria - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphorylation - drug effects Plant extracts Protein expression Proteins Proto-Oncogene Proteins c-akt - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, Tumor Necrosis Factor, Member 25 - metabolism S Phase Cell Cycle Checkpoints - drug effects Signal Transduction - drug effects Stomach cancer Stomach Neoplasms - drug therapy Stomach Neoplasms - pathology Studies |
| title | Cordycepin induces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS |
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