Oral Immunization and Allergenicity Induced by Lablab purpureus (L.) Sweet Seeds Proteins in Mice and Their Modulation by Carbohydrates
The Mangalô bean (Lablab purpureus (L.) Sweet) is consumed in many places around the world, including Brazil. These leguminous contain Lectins, which are glycoproteins that bound to glico- conjugates and induce many biological responses. The present study is a research on the immunogenic capacity of...
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| Veröffentlicht in: | Revista brasileira em promoção da saúde = Brazilian journal in health promotion 2005-01, Vol.18 (2), p.90 |
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| creator | Pinho Pereira, Márcio Roberto Maria Izabel Florindo Guedes |
| description | The Mangalô bean (Lablab purpureus (L.) Sweet) is consumed in many places around the world, including Brazil. These leguminous contain Lectins, which are glycoproteins that bound to glico- conjugates and induce many biological responses. The present study is a research on the immunogenic capacity of the Lablab purpureus seeds proteins in orally immunized mice. The lectins’ ability to act as humoral immune response modulators when associated to egg albumin (OVA) and carbohydrates was also analyzed. Mice groups were immunized respectively with L. purpureus total exctract (ET), with L. purpureus ET associated to OVA and L. purpureus ET associated with different carbohydrates, by oral route. The mice fed with the L. purpureus total extract (ET) synthesized specific serological antibodies anti-ET and that response was due to the proteins of high molecular weight (above 45kDa). When the ET was associated to different sugars, the synthesis of specific antibodies anti-ET was mostly inhibited by N-Acetil-D-Glucosamine (p |
| doi_str_mv | 10.5020/912 |
| format | Article |
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Mice groups were immunized respectively with L. purpureus total exctract (ET), with L. purpureus ET associated to OVA and L. purpureus ET associated with different carbohydrates, by oral route. The mice fed with the L. purpureus total extract (ET) synthesized specific serological antibodies anti-ET and that response was due to the proteins of high molecular weight (above 45kDa). When the ET was associated to different sugars, the synthesis of specific antibodies anti-ET was mostly inhibited by N-Acetil-D-Glucosamine (p<0.05), followed by Manose, Glucose and Galactose. The ET did not show any modulator effect when associated to egg albumin. 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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antibodies Carbohydrates Galactose Immune system Immunization Lectins Mice Modulators Proteins Seeds Sugar |
| title | Oral Immunization and Allergenicity Induced by Lablab purpureus (L.) Sweet Seeds Proteins in Mice and Their Modulation by Carbohydrates |
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