Cytochalasin E in the lichen Pleurosticta acetabulum. Anti-proliferative activity against human HT-29 colorectal cancer cells and quantitative variability
A biological screening of sixteen lichen extracts on human HT-29 colorectal cancer cells, led to the selection of Pleurosticta acetabulum, a lichen widely present in tree barks in Europe. Bioguided purification of the acetonic extract resulted in the isolation of cytochalasin E, a common fungal meta...
Gespeichert in:
| Veröffentlicht in: | Fitoterapia 2017-09, Vol.121, p.146-151 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 151 |
|---|---|
| container_issue | |
| container_start_page | 146 |
| container_title | Fitoterapia |
| container_volume | 121 |
| creator | Delebassée, Sylvie Mambu, Lengo Pinault, Emilie Champavier, Yves Liagre, Bertrand Millot, Marion |
| description | A biological screening of sixteen lichen extracts on human HT-29 colorectal cancer cells, led to the selection of Pleurosticta acetabulum, a lichen widely present in tree barks in Europe. Bioguided purification of the acetonic extract resulted in the isolation of cytochalasin E, a common fungal metabolite. This compound is responsible for the anti-proliferative activity of the extract. Its presence in lichens is reported here for the first time. LC-MS quantitation of cytochalasin E in different samples of P. acetabulum demonstrated quantitative variations of cytochalasin E production in the lichen and especially high concentrations in apothecia.
[Display omitted] |
| doi_str_mv | 10.1016/j.fitote.2017.07.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1957210676</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0367326X17306688</els_id><sourcerecordid>1957210676</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-704736ef0963e81c49ac93494cd0bdd74f5135cf34c3b65fe5a7eaa02369487e3</originalsourceid><addsrcrecordid>eNp9kcFq3DAQhkVpabZp36AUQc92RpYtrS6FsKRNIdAeUuhNzMrjrhatnUjywr5KnzZanPYYGDQH_fMN8_-MfRRQCxDqal8PPk-Z6gaErqEUqFdsJdZaVspo8ZqtQCpdyUb9vmDvUtoDiE624i27aNYaug7Miv3dnPLkdhgw-ZHf8PLkHfHg3Y5G_jPQHKeUvcvI0VHG7RzmQ82vx-yrhzgFP1DE7I9Uvkvz-cTxD_oxZb6bDzjy2_uqMdxNYYpUKIE7HB1F7iiExHHs-eOMhZYXyhGjx60PBfSevRkwJPrw3C_Zr68395vb6u7Ht--b67vKSQO50tBqqWgAoySthWsNOiNb07oetn2v26ETsnODbJ3cqm6gDjUhQiOVadea5CX7vHDLPY8zpWz30xzHstIK0-lGgNKqqNpF5YohKdJgH6I_YDxZAfYciN3bJRB7DsRCKTiPfXqGz9sD9f-H_iVQBF8WAZUTj56iTc5Tsaj3Z8NsP_mXNzwB9kuhRg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1957210676</pqid></control><display><type>article</type><title>Cytochalasin E in the lichen Pleurosticta acetabulum. Anti-proliferative activity against human HT-29 colorectal cancer cells and quantitative variability</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Delebassée, Sylvie ; Mambu, Lengo ; Pinault, Emilie ; Champavier, Yves ; Liagre, Bertrand ; Millot, Marion</creator><creatorcontrib>Delebassée, Sylvie ; Mambu, Lengo ; Pinault, Emilie ; Champavier, Yves ; Liagre, Bertrand ; Millot, Marion</creatorcontrib><description>A biological screening of sixteen lichen extracts on human HT-29 colorectal cancer cells, led to the selection of Pleurosticta acetabulum, a lichen widely present in tree barks in Europe. Bioguided purification of the acetonic extract resulted in the isolation of cytochalasin E, a common fungal metabolite. This compound is responsible for the anti-proliferative activity of the extract. Its presence in lichens is reported here for the first time. LC-MS quantitation of cytochalasin E in different samples of P. acetabulum demonstrated quantitative variations of cytochalasin E production in the lichen and especially high concentrations in apothecia.
[Display omitted]</description><identifier>ISSN: 0367-326X</identifier><identifier>EISSN: 1873-6971</identifier><identifier>DOI: 10.1016/j.fitote.2017.07.006</identifier><identifier>PMID: 28705509</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acetabulum ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Antiproliferatives ; Apoptosis - drug effects ; Apothecia ; Cancer ; Cell Proliferation - drug effects ; Cells ; Colorectal cancer ; Colorectal cancer cells ; Colorectal carcinoma ; Cytochalasin E ; Cytochalasins - isolation & purification ; Cytochalasins - pharmacology ; HT29 Cells ; Humans ; Lichen ; Lichens ; Lichens - chemistry ; Metabolites ; Parmeliaceae ; Pleurosticta acetabulum ; Purification ; Quantitation</subject><ispartof>Fitoterapia, 2017-09, Vol.121, p.146-151</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Sep 2017</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-704736ef0963e81c49ac93494cd0bdd74f5135cf34c3b65fe5a7eaa02369487e3</citedby><cites>FETCH-LOGICAL-c390t-704736ef0963e81c49ac93494cd0bdd74f5135cf34c3b65fe5a7eaa02369487e3</cites><orcidid>0000-0001-8811-2661</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0367326X17306688$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28705509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delebassée, Sylvie</creatorcontrib><creatorcontrib>Mambu, Lengo</creatorcontrib><creatorcontrib>Pinault, Emilie</creatorcontrib><creatorcontrib>Champavier, Yves</creatorcontrib><creatorcontrib>Liagre, Bertrand</creatorcontrib><creatorcontrib>Millot, Marion</creatorcontrib><title>Cytochalasin E in the lichen Pleurosticta acetabulum. Anti-proliferative activity against human HT-29 colorectal cancer cells and quantitative variability</title><title>Fitoterapia</title><addtitle>Fitoterapia</addtitle><description>A biological screening of sixteen lichen extracts on human HT-29 colorectal cancer cells, led to the selection of Pleurosticta acetabulum, a lichen widely present in tree barks in Europe. Bioguided purification of the acetonic extract resulted in the isolation of cytochalasin E, a common fungal metabolite. This compound is responsible for the anti-proliferative activity of the extract. Its presence in lichens is reported here for the first time. LC-MS quantitation of cytochalasin E in different samples of P. acetabulum demonstrated quantitative variations of cytochalasin E production in the lichen and especially high concentrations in apothecia.
[Display omitted]</description><subject>Acetabulum</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antiproliferatives</subject><subject>Apoptosis - drug effects</subject><subject>Apothecia</subject><subject>Cancer</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells</subject><subject>Colorectal cancer</subject><subject>Colorectal cancer cells</subject><subject>Colorectal carcinoma</subject><subject>Cytochalasin E</subject><subject>Cytochalasins - isolation & purification</subject><subject>Cytochalasins - pharmacology</subject><subject>HT29 Cells</subject><subject>Humans</subject><subject>Lichen</subject><subject>Lichens</subject><subject>Lichens - chemistry</subject><subject>Metabolites</subject><subject>Parmeliaceae</subject><subject>Pleurosticta acetabulum</subject><subject>Purification</subject><subject>Quantitation</subject><issn>0367-326X</issn><issn>1873-6971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFq3DAQhkVpabZp36AUQc92RpYtrS6FsKRNIdAeUuhNzMrjrhatnUjywr5KnzZanPYYGDQH_fMN8_-MfRRQCxDqal8PPk-Z6gaErqEUqFdsJdZaVspo8ZqtQCpdyUb9vmDvUtoDiE624i27aNYaug7Miv3dnPLkdhgw-ZHf8PLkHfHg3Y5G_jPQHKeUvcvI0VHG7RzmQ82vx-yrhzgFP1DE7I9Uvkvz-cTxD_oxZb6bDzjy2_uqMdxNYYpUKIE7HB1F7iiExHHs-eOMhZYXyhGjx60PBfSevRkwJPrw3C_Zr68395vb6u7Ht--b67vKSQO50tBqqWgAoySthWsNOiNb07oetn2v26ETsnODbJ3cqm6gDjUhQiOVadea5CX7vHDLPY8zpWz30xzHstIK0-lGgNKqqNpF5YohKdJgH6I_YDxZAfYciN3bJRB7DsRCKTiPfXqGz9sD9f-H_iVQBF8WAZUTj56iTc5Tsaj3Z8NsP_mXNzwB9kuhRg</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Delebassée, Sylvie</creator><creator>Mambu, Lengo</creator><creator>Pinault, Emilie</creator><creator>Champavier, Yves</creator><creator>Liagre, Bertrand</creator><creator>Millot, Marion</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0001-8811-2661</orcidid></search><sort><creationdate>201709</creationdate><title>Cytochalasin E in the lichen Pleurosticta acetabulum. Anti-proliferative activity against human HT-29 colorectal cancer cells and quantitative variability</title><author>Delebassée, Sylvie ; Mambu, Lengo ; Pinault, Emilie ; Champavier, Yves ; Liagre, Bertrand ; Millot, Marion</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-704736ef0963e81c49ac93494cd0bdd74f5135cf34c3b65fe5a7eaa02369487e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acetabulum</topic><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antiproliferatives</topic><topic>Apoptosis - drug effects</topic><topic>Apothecia</topic><topic>Cancer</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells</topic><topic>Colorectal cancer</topic><topic>Colorectal cancer cells</topic><topic>Colorectal carcinoma</topic><topic>Cytochalasin E</topic><topic>Cytochalasins - isolation & purification</topic><topic>Cytochalasins - pharmacology</topic><topic>HT29 Cells</topic><topic>Humans</topic><topic>Lichen</topic><topic>Lichens</topic><topic>Lichens - chemistry</topic><topic>Metabolites</topic><topic>Parmeliaceae</topic><topic>Pleurosticta acetabulum</topic><topic>Purification</topic><topic>Quantitation</topic><toplevel>online_resources</toplevel><creatorcontrib>Delebassée, Sylvie</creatorcontrib><creatorcontrib>Mambu, Lengo</creatorcontrib><creatorcontrib>Pinault, Emilie</creatorcontrib><creatorcontrib>Champavier, Yves</creatorcontrib><creatorcontrib>Liagre, Bertrand</creatorcontrib><creatorcontrib>Millot, Marion</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Fitoterapia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delebassée, Sylvie</au><au>Mambu, Lengo</au><au>Pinault, Emilie</au><au>Champavier, Yves</au><au>Liagre, Bertrand</au><au>Millot, Marion</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytochalasin E in the lichen Pleurosticta acetabulum. Anti-proliferative activity against human HT-29 colorectal cancer cells and quantitative variability</atitle><jtitle>Fitoterapia</jtitle><addtitle>Fitoterapia</addtitle><date>2017-09</date><risdate>2017</risdate><volume>121</volume><spage>146</spage><epage>151</epage><pages>146-151</pages><issn>0367-326X</issn><eissn>1873-6971</eissn><abstract>A biological screening of sixteen lichen extracts on human HT-29 colorectal cancer cells, led to the selection of Pleurosticta acetabulum, a lichen widely present in tree barks in Europe. Bioguided purification of the acetonic extract resulted in the isolation of cytochalasin E, a common fungal metabolite. This compound is responsible for the anti-proliferative activity of the extract. Its presence in lichens is reported here for the first time. LC-MS quantitation of cytochalasin E in different samples of P. acetabulum demonstrated quantitative variations of cytochalasin E production in the lichen and especially high concentrations in apothecia.
[Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28705509</pmid><doi>10.1016/j.fitote.2017.07.006</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8811-2661</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0367-326X |
| ispartof | Fitoterapia, 2017-09, Vol.121, p.146-151 |
| issn | 0367-326X 1873-6971 |
| language | eng |
| recordid | cdi_proquest_journals_1957210676 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetabulum Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Antiproliferatives Apoptosis - drug effects Apothecia Cancer Cell Proliferation - drug effects Cells Colorectal cancer Colorectal cancer cells Colorectal carcinoma Cytochalasin E Cytochalasins - isolation & purification Cytochalasins - pharmacology HT29 Cells Humans Lichen Lichens Lichens - chemistry Metabolites Parmeliaceae Pleurosticta acetabulum Purification Quantitation |
| title | Cytochalasin E in the lichen Pleurosticta acetabulum. Anti-proliferative activity against human HT-29 colorectal cancer cells and quantitative variability |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T10%3A39%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytochalasin%20E%20in%20the%20lichen%20Pleurosticta%20acetabulum.%20Anti-proliferative%20activity%20against%20human%20HT-29%20colorectal%20cancer%20cells%20and%20quantitative%20variability&rft.jtitle=Fitoterapia&rft.au=Delebass%C3%A9e,%20Sylvie&rft.date=2017-09&rft.volume=121&rft.spage=146&rft.epage=151&rft.pages=146-151&rft.issn=0367-326X&rft.eissn=1873-6971&rft_id=info:doi/10.1016/j.fitote.2017.07.006&rft_dat=%3Cproquest_cross%3E1957210676%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1957210676&rft_id=info:pmid/28705509&rft_els_id=S0367326X17306688&rfr_iscdi=true |