Effects of combinations of anti‐rheumatic drugs on the production of vascular endothelial growth factor and basic fibroblast growth factor in cultured synoviocytes and patients with rheumatoid arthritis

Objective. To examine whether different combinations of disease‐modifying anti‐rheumatic drugs (DMARDs), including bucillamine (BUC), gold sodium thiomalate (GST), methotrexate (MTX), salazosulphapyridine (SASP) and dexamethasone (DEX; a steroid), act by inhibiting the production of vascular endothe...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2000-11, Vol.39 (11), p.1255-1262
Hauptverfasser:	Nagashima, M., Wauke, K., Hirano, D., Ishigami, S., Aono, H., Takai, M., Sasano, M., Yoshino, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antirheumatic Agents - pharmacology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - metabolism Basic fibroblast growth factor Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents C-Reactive Protein - metabolism Cells, Cultured Cysteine - analogs & derivatives Cysteine - pharmacology Dexamethasone - pharmacology Disease‐modifying anti‐rheumatic drugs Drug Synergism Drug Therapy, Combination Endothelial Growth Factors - biosynthesis Endothelial Growth Factors - blood Fibroblast Growth Factor 2 - biosynthesis Fibroblast Growth Factor 2 - blood Gold Sodium Thiomalate - pharmacology Humans In Vitro Techniques Lipopolysaccharides Lymphokines - biosynthesis Lymphokines - blood Medical sciences Methotrexate - pharmacology Pharmacology. Drug treatments Rheumatoid arthritis Sulfasalazine - pharmacology Synovial Membrane - cytology Synovial Membrane - drug effects Synovial Membrane - metabolism Vascular endothelial growth factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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