Hepatoprotective effect of hesperidin in hepatocellular carcinoma: Involvement of Wnt signaling pathways

Wnt3a and Wnt5a are ligands orchestrating the canonical and non-canonical pathways, respectively, with involvement in hepatocellular carcinoma (HCC). Hesperidin (HP) is a natural product found in citrus fruits and reputed for its antitumor activity. The present study aims to investigate the potentia...

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Veröffentlicht in:	Life sciences (1973) 2017-09, Vol.185, p.114-125
Hauptverfasser:	Zaghloul, Randa A., Elsherbiny, Nehal M., Kenawy, Hany I., El-Karef, Amr, Eissa, Laila A., El-Shishtawy, Mamdouh M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer properties Antitumor activity Cancer Carcinogens Carcinoma, Hepatocellular - prevention & control Caspase Caspase-3 Cyclin D1 Enzyme-linked immunosorbent assay Gene Expression Regulation - drug effects Group dynamics Hepatocellular carcinoma Hesperidin Hesperidin - pharmacology Immunohistochemistry Ligands Liver Liver Neoplasms - prevention & control Male Oxidative stress Oxidative Stress - drug effects Peroxidase Rats Rats, Sprague-Dawley Receiving Rodents Signal transduction Signaling Thioacetamide Thioacetamide - toxicity Wnt protein Wnt Signaling Pathway - drug effects Wnt-5a Protein - metabolism Wnt3a Wnt3A Protein - metabolism Wnt5a β-Catenin
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