The cholesterol lowering properties of the complex compound simvastatin with glycyrrhizic acid (simvaglyzin) in experimental models

A molecular complex of simvastatin (SV) and glycyrrhizic acid (GA) (at their ratio of 1 : 4) has been synthesized. The complex named “simvaglyzin” (SVG) was stable in aqueous and aqueous-alcohol solutions at GA concentrations exceeding 0.2 mM. In vitro SVG acted as an uncompetitive inhibitor of 3-hy...

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Veröffentlicht in:	Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2008-12, Vol.2 (4), p.373-380
Hauptverfasser:	Vavilin, V. A., Salakhutdinov, N. F., Ragino, Yu. I., Polyakov, N. E., Taraban, M. B., Leshina, T. V., Stakhneva, E. M., Lyakhovich, V. V., Nikitin, Yu. P., Tolstikov, G. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Bioorganic Chemistry Chemistry Chemistry and Materials Science Cholesterol Experimental Studies Medicinal Chemistry Molecular biology Pharmacology Rodents Toxicity
Online-Zugang:	Volltext
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