Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut–Liver Axis

Background Cirrhosis and alcohol can independently affect the gut–liver axis with systemic inflammation. However, their concurrent impact in humans is unclear. Methods Our aim was to determine the effect of continued alcohol misuse on the gut‐liver axis in cirrhotic patients. Age‐ and MELD‐balanced...

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Veröffentlicht in:	Alcoholism, clinical and experimental research clinical and experimental research, 2017-11, Vol.41 (11), p.1857-1865
Hauptverfasser:	Bajaj, Jasmohan S., Kakiyama, Genta, Zhao, Derrick, Takei, Hajime, Fagan, Andrew, Hylemon, Phillip, Zhou, Huiping, Pandak, William M., Nittono, Hiroshi, Fiehn, Oliver, Salzman, Nita, Holtz, Mary, Simpson, Pippa, Gavis, Edith A., Heuman, Douglas M., Liu, Runping, Kang, Dae Joong, Sikaroodi, Masoumeh, Gillevet, Patrick M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohol abuse Alcohol use Alcoholism - diagnosis Alcoholism - epidemiology Alcoholism - physiopathology Amino acids Bile Acids Cirrhosis Colon Digestive system Drinking behavior Duodenum Dysbacteriosis Dysbiosis - diagnosis Dysbiosis - epidemiology Dysbiosis - physiopathology Endoscopy Endoscopy, Digestive System - methods Endotoxemia Fecal microflora Feces Female Fibroblast growth factors Functionality Gas chromatography Gastrointestinal tract Gastrointestinal Tract - physiopathology Glycine Humans Ileum Inflammation Intestine Liver Liver cirrhosis Liver Cirrhosis - diagnosis Liver Cirrhosis - epidemiology Liver Cirrhosis - physiopathology Male Mass spectroscopy Metabolites Metabolomics Microbiota Microbiota - physiology Middle Aged Mucosa
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