Modified tunicamycins with reduced eukaryotic toxicity that enhance the antibacterial activity of [beta]-lactams

Tunicamycins (TUN) are inhibitors of the UDP-HexNAc: polyprenol-P HexNAc-1-P transferase family of enzymes, which initiate the biosynthesis of bacterial peptidoglycan and catalyze the first step in eukaryotic protein N-glycosylation. The TUN are therefore general and potent toxins to both eukaryotes...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of antibiotics 2017-11, Vol.70 (11), p.1070
Hauptverfasser:	Price, Neil Pj, Hartman, Trina M, Li, Jiakun, Velpula, Kiran K, Naumann, Todd A, Guda, Maheedhara R, Yu, Biao, Bischoff, Kenneth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioassays Biosynthesis Proteins Toxicity Toxins Yeasts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!