Antiproliferative effect of apocynin in cervical epithelial cells infected by HPV 16 involves change of ROS production and cell cycle
The cervical cancer is characterized as a public health problem. The human papillomavirus, especially the high-risk types 16 and 18, is present in 99.7% of cases of invasive cervical cancers. Due to high prevalence, the search for new drugs for the treatment is continuous. The apocynin, compound bel...
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| Veröffentlicht in: | Medicinal chemistry research 2017-11, Vol.26 (11), p.2853-2860 |
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| creator | Lima, Natália Alves Santana, Natália de Carvalho Scharf de Lima, Nayara Cristina Alves Lazarin-Bidóia, Danielle Bonfim-Mendonça, Patrícia de Souza Ueda Nakamura, Tânia Nakamura, Celso Vataru Consolaro, Marcia Edilaine Lopes Ximenes, Valdecir Farias Silva, Sueli de Oliveira |
| description | The cervical cancer is characterized as a public health problem. The human papillomavirus, especially the high-risk types 16 and 18, is present in 99.7% of cases of invasive cervical cancers. Due to high prevalence, the search for new drugs for the treatment is continuous. The apocynin, compound belonging to the class of catechol-methoxy acetophenone, has been used as an effective and non-toxic inhibitor of the NADPH oxidase complex, in many experimental models. Some early studies have indicated that apocynin also exerts antiproliferative activity inducing cell death by apoptosis. Thus, we evaluated the effect of apocynin in cervical epithelial cells infected by human papillomavirus 16 (SiHa cells) by analyzing oxygen species production, cell cycle, cell morphology, cell volume, membrane integrity and mitochondria membrane potential. Our data showed that apocynin induces antiproliferative effects by decreasing reactive oxygen species production and inducing cell cycle arrest, activating pathways that induce apoptosis cell death. |
| doi_str_mv | 10.1007/s00044-017-1984-9 |
| format | Article |
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The human papillomavirus, especially the high-risk types 16 and 18, is present in 99.7% of cases of invasive cervical cancers. Due to high prevalence, the search for new drugs for the treatment is continuous. The apocynin, compound belonging to the class of catechol-methoxy acetophenone, has been used as an effective and non-toxic inhibitor of the NADPH oxidase complex, in many experimental models. Some early studies have indicated that apocynin also exerts antiproliferative activity inducing cell death by apoptosis. Thus, we evaluated the effect of apocynin in cervical epithelial cells infected by human papillomavirus 16 (SiHa cells) by analyzing oxygen species production, cell cycle, cell morphology, cell volume, membrane integrity and mitochondria membrane potential. Our data showed that apocynin induces antiproliferative effects by decreasing reactive oxygen species production and inducing cell cycle arrest, activating pathways that induce apoptosis cell death.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-017-1984-9</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acetophenone ; Antiproliferatives ; Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Catechol ; Cell Biology ; Cell cycle ; Cell death ; Cell size ; Cervical cancer ; Cervix ; Cytology ; Epithelial cells ; Human papillomavirus ; Invasiveness ; Membrane potential ; Mitochondria ; NAD(P)H oxidase ; Original Research ; Pharmacology/Toxicology ; Public health ; Reactive oxygen species</subject><ispartof>Medicinal chemistry research, 2017-11, Vol.26 (11), p.2853-2860</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-7c61a1b654e0aaa44c05e51c9c0a9dee5d7941bba1b318253416c4f4c1b7ae3f3</citedby><cites>FETCH-LOGICAL-c359t-7c61a1b654e0aaa44c05e51c9c0a9dee5d7941bba1b318253416c4f4c1b7ae3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00044-017-1984-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00044-017-1984-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Lima, Natália Alves</creatorcontrib><creatorcontrib>Santana, Natália de Carvalho Scharf</creatorcontrib><creatorcontrib>de Lima, Nayara Cristina Alves</creatorcontrib><creatorcontrib>Lazarin-Bidóia, Danielle</creatorcontrib><creatorcontrib>Bonfim-Mendonça, Patrícia de Souza</creatorcontrib><creatorcontrib>Ueda Nakamura, Tânia</creatorcontrib><creatorcontrib>Nakamura, Celso Vataru</creatorcontrib><creatorcontrib>Consolaro, Marcia Edilaine Lopes</creatorcontrib><creatorcontrib>Ximenes, Valdecir Farias</creatorcontrib><creatorcontrib>Silva, Sueli de Oliveira</creatorcontrib><title>Antiproliferative effect of apocynin in cervical epithelial cells infected by HPV 16 involves change of ROS production and cell cycle</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>The cervical cancer is characterized as a public health problem. The human papillomavirus, especially the high-risk types 16 and 18, is present in 99.7% of cases of invasive cervical cancers. Due to high prevalence, the search for new drugs for the treatment is continuous. The apocynin, compound belonging to the class of catechol-methoxy acetophenone, has been used as an effective and non-toxic inhibitor of the NADPH oxidase complex, in many experimental models. Some early studies have indicated that apocynin also exerts antiproliferative activity inducing cell death by apoptosis. Thus, we evaluated the effect of apocynin in cervical epithelial cells infected by human papillomavirus 16 (SiHa cells) by analyzing oxygen species production, cell cycle, cell morphology, cell volume, membrane integrity and mitochondria membrane potential. Our data showed that apocynin induces antiproliferative effects by decreasing reactive oxygen species production and inducing cell cycle arrest, activating pathways that induce apoptosis cell death.</description><subject>Acetophenone</subject><subject>Antiproliferatives</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Catechol</subject><subject>Cell Biology</subject><subject>Cell cycle</subject><subject>Cell death</subject><subject>Cell size</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Cytology</subject><subject>Epithelial cells</subject><subject>Human papillomavirus</subject><subject>Invasiveness</subject><subject>Membrane potential</subject><subject>Mitochondria</subject><subject>NAD(P)H oxidase</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><subject>Public health</subject><subject>Reactive oxygen species</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1UE1LxDAQLaLguvoDvAU8VzNt0m6Py6KusLDi1zWk06mbpbY16Rb6A_zfptaDFyFDHpP33kxeEFwCvwbO0xvHORci5JCGkC1EmB0FM5BShAuI-LHH3ONIRvFpcObcnvM45ULOgq9l3ZnWNpUpyerO9MSoLAk71pRMtw0OtamZP0i2N6grRq3pdlQZD5GqyvnHkU8Fywe2fnxjkPhW31Q9OYY7Xb_T6PW0fWZ-TnHAzjQ103XxI2c4YEXnwUmpK0cXv_c8eL27fVmtw832_mG13IQYy6wLU0xAQ55IQVxrLQRySRIwQ66zgkgWaSYgzz0nhkUkYwEJilIg5KmmuIznwdXk6zf5PJDr1L452NqPVJBJKX2liWfBxELbOGepVK01H9oOCrga01ZT2sqnrca0VeY10aRxnuu_bP84_yv6Bihlg6g</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Lima, Natália Alves</creator><creator>Santana, Natália de Carvalho Scharf</creator><creator>de Lima, Nayara Cristina Alves</creator><creator>Lazarin-Bidóia, Danielle</creator><creator>Bonfim-Mendonça, Patrícia de Souza</creator><creator>Ueda Nakamura, Tânia</creator><creator>Nakamura, Celso Vataru</creator><creator>Consolaro, Marcia Edilaine Lopes</creator><creator>Ximenes, Valdecir Farias</creator><creator>Silva, Sueli de Oliveira</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>20171101</creationdate><title>Antiproliferative effect of apocynin in cervical epithelial cells infected by HPV 16 involves change of ROS production and cell cycle</title><author>Lima, Natália Alves ; Santana, Natália de Carvalho Scharf ; de Lima, Nayara Cristina Alves ; Lazarin-Bidóia, Danielle ; Bonfim-Mendonça, Patrícia de Souza ; Ueda Nakamura, Tânia ; Nakamura, Celso Vataru ; Consolaro, Marcia Edilaine Lopes ; Ximenes, Valdecir Farias ; Silva, Sueli de Oliveira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-7c61a1b654e0aaa44c05e51c9c0a9dee5d7941bba1b318253416c4f4c1b7ae3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acetophenone</topic><topic>Antiproliferatives</topic><topic>Apoptosis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Catechol</topic><topic>Cell Biology</topic><topic>Cell cycle</topic><topic>Cell death</topic><topic>Cell size</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Cytology</topic><topic>Epithelial cells</topic><topic>Human papillomavirus</topic><topic>Invasiveness</topic><topic>Membrane potential</topic><topic>Mitochondria</topic><topic>NAD(P)H oxidase</topic><topic>Original Research</topic><topic>Pharmacology/Toxicology</topic><topic>Public health</topic><topic>Reactive oxygen species</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lima, Natália Alves</creatorcontrib><creatorcontrib>Santana, Natália de Carvalho Scharf</creatorcontrib><creatorcontrib>de Lima, Nayara Cristina Alves</creatorcontrib><creatorcontrib>Lazarin-Bidóia, Danielle</creatorcontrib><creatorcontrib>Bonfim-Mendonça, Patrícia de Souza</creatorcontrib><creatorcontrib>Ueda Nakamura, Tânia</creatorcontrib><creatorcontrib>Nakamura, Celso Vataru</creatorcontrib><creatorcontrib>Consolaro, Marcia Edilaine Lopes</creatorcontrib><creatorcontrib>Ximenes, Valdecir Farias</creatorcontrib><creatorcontrib>Silva, Sueli de Oliveira</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lima, Natália Alves</au><au>Santana, Natália de Carvalho Scharf</au><au>de Lima, Nayara Cristina Alves</au><au>Lazarin-Bidóia, Danielle</au><au>Bonfim-Mendonça, Patrícia de Souza</au><au>Ueda Nakamura, Tânia</au><au>Nakamura, Celso Vataru</au><au>Consolaro, Marcia Edilaine Lopes</au><au>Ximenes, Valdecir Farias</au><au>Silva, Sueli de Oliveira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiproliferative effect of apocynin in cervical epithelial cells infected by HPV 16 involves change of ROS production and cell cycle</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2017-11-01</date><risdate>2017</risdate><volume>26</volume><issue>11</issue><spage>2853</spage><epage>2860</epage><pages>2853-2860</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>The cervical cancer is characterized as a public health problem. The human papillomavirus, especially the high-risk types 16 and 18, is present in 99.7% of cases of invasive cervical cancers. Due to high prevalence, the search for new drugs for the treatment is continuous. The apocynin, compound belonging to the class of catechol-methoxy acetophenone, has been used as an effective and non-toxic inhibitor of the NADPH oxidase complex, in many experimental models. Some early studies have indicated that apocynin also exerts antiproliferative activity inducing cell death by apoptosis. Thus, we evaluated the effect of apocynin in cervical epithelial cells infected by human papillomavirus 16 (SiHa cells) by analyzing oxygen species production, cell cycle, cell morphology, cell volume, membrane integrity and mitochondria membrane potential. Our data showed that apocynin induces antiproliferative effects by decreasing reactive oxygen species production and inducing cell cycle arrest, activating pathways that induce apoptosis cell death.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00044-017-1984-9</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetophenone Antiproliferatives Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Catechol Cell Biology Cell cycle Cell death Cell size Cervical cancer Cervix Cytology Epithelial cells Human papillomavirus Invasiveness Membrane potential Mitochondria NAD(P)H oxidase Original Research Pharmacology/Toxicology Public health Reactive oxygen species |
| title | Antiproliferative effect of apocynin in cervical epithelial cells infected by HPV 16 involves change of ROS production and cell cycle |
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