Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities
A new 8-prenyl-flavonoid, epimedokoreanoside III, and 11 other flavonoids, were isolated from the aerial parts of Epimedium koreanum Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and t...
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| Veröffentlicht in: | Medicinal chemistry research 2017-11, Vol.26 (11), p.2761-2767 |
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| creator | Dong Su, Xiang Li, Wei Eun Kim, Ji Young Yang, Seo Yeul Ma, Jin Ho Kim, Young |
| description | A new 8-prenyl-flavonoid, epimedokoreanoside III, and 11 other flavonoids, were isolated from the aerial parts of
Epimedium koreanum
Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and tyrosinase inhibitory activities. Among the isolates, compounds
1
,
5
,
9
,
10
, and
12
exerted soluble epoxide hydrolase inhibitory activity in dose-dependent manner, with IC
50
values ranging from 26.0 ± 1.2 to 37.6 ± 1.0 µM, whereas compounds
4
and
9
showed potent inhibition of tyrosinase in a dose-dependent manner, having IC
50
values of 16.8 ± 2.7 and 8.7 ± 2.7 µM, respectively. |
| doi_str_mv | 10.1007/s00044-017-1975-x |
| format | Article |
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Epimedium koreanum
Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and tyrosinase inhibitory activities. Among the isolates, compounds
1
,
5
,
9
,
10
, and
12
exerted soluble epoxide hydrolase inhibitory activity in dose-dependent manner, with IC
50
values ranging from 26.0 ± 1.2 to 37.6 ± 1.0 µM, whereas compounds
4
and
9
showed potent inhibition of tyrosinase in a dose-dependent manner, having IC
50
values of 16.8 ± 2.7 and 8.7 ± 2.7 µM, respectively.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-017-1975-x</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Epoxide hydrolase ; Flavonoids ; NMR ; Nuclear magnetic resonance ; Original Research ; Pharmacology/Toxicology ; Tyrosinase</subject><ispartof>Medicinal chemistry research, 2017-11, Vol.26 (11), p.2761-2767</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-4d8d68954f58a344e5b6745304f07dd2ccb5a63ba68b23ab6fc711b5017dfeb03</citedby><cites>FETCH-LOGICAL-c316t-4d8d68954f58a344e5b6745304f07dd2ccb5a63ba68b23ab6fc711b5017dfeb03</cites><orcidid>0000-0001-7272-7290</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00044-017-1975-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00044-017-1975-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Dong Su, Xiang</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Eun Kim, Ji</creatorcontrib><creatorcontrib>Young Yang, Seo</creatorcontrib><creatorcontrib>Yeul Ma, Jin</creatorcontrib><creatorcontrib>Ho Kim, Young</creatorcontrib><title>Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>A new 8-prenyl-flavonoid, epimedokoreanoside III, and 11 other flavonoids, were isolated from the aerial parts of
Epimedium koreanum
Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and tyrosinase inhibitory activities. Among the isolates, compounds
1
,
5
,
9
,
10
, and
12
exerted soluble epoxide hydrolase inhibitory activity in dose-dependent manner, with IC
50
values ranging from 26.0 ± 1.2 to 37.6 ± 1.0 µM, whereas compounds
4
and
9
showed potent inhibition of tyrosinase in a dose-dependent manner, having IC
50
values of 16.8 ± 2.7 and 8.7 ± 2.7 µM, respectively.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Epoxide hydrolase</subject><subject>Flavonoids</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><subject>Tyrosinase</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kM1OwzAQhCMEEqXwANwscQ6sEztOj6gqP1IFHOBs2bFD3SZ2sBOUvD2uwoELp52VvpldTZJcY7jFAOwuAAAhKWCW4hWj6XiSLDClJC1xBqdRQ9QZzfLz5CKEPUDOgNBFMr55bacmrRvx7awzKqDauxZtOtNqZYYWHZzXwkbxIg7CIGEV6nfaeBRcM8hGI9250SiNdpPyrhFBz8zkXTD2uBq7M9L0zk9IVL35Nr3R4TI5q0UT9NXvXCYfD5v39VO6fX18Xt9v0yrHRZ8SVaqiXFFS01LkhGgqC0ZoDqQGplRWVZKKIpeiKGWWC1nUFcNY0liEqrWEfJnczLmdd1-DDj3fu8HbeJLjFaW0pAxopPBMVfHr4HXNO29a4SeOgR8L5nPBPObyY8F8jJ5s9oTI2k_t_yT_a_oB-Z6Bcg</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Dong Su, Xiang</creator><creator>Li, Wei</creator><creator>Eun Kim, Ji</creator><creator>Young Yang, Seo</creator><creator>Yeul Ma, Jin</creator><creator>Ho Kim, Young</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0001-7272-7290</orcidid></search><sort><creationdate>20171101</creationdate><title>Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities</title><author>Dong Su, Xiang ; Li, Wei ; Eun Kim, Ji ; Young Yang, Seo ; Yeul Ma, Jin ; Ho Kim, Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-4d8d68954f58a344e5b6745304f07dd2ccb5a63ba68b23ab6fc711b5017dfeb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Epoxide hydrolase</topic><topic>Flavonoids</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Original Research</topic><topic>Pharmacology/Toxicology</topic><topic>Tyrosinase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong Su, Xiang</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Eun Kim, Ji</creatorcontrib><creatorcontrib>Young Yang, Seo</creatorcontrib><creatorcontrib>Yeul Ma, Jin</creatorcontrib><creatorcontrib>Ho Kim, Young</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong Su, Xiang</au><au>Li, Wei</au><au>Eun Kim, Ji</au><au>Young Yang, Seo</au><au>Yeul Ma, Jin</au><au>Ho Kim, Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2017-11-01</date><risdate>2017</risdate><volume>26</volume><issue>11</issue><spage>2761</spage><epage>2767</epage><pages>2761-2767</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>A new 8-prenyl-flavonoid, epimedokoreanoside III, and 11 other flavonoids, were isolated from the aerial parts of
Epimedium koreanum
Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and tyrosinase inhibitory activities. Among the isolates, compounds
1
,
5
,
9
,
10
, and
12
exerted soluble epoxide hydrolase inhibitory activity in dose-dependent manner, with IC
50
values ranging from 26.0 ± 1.2 to 37.6 ± 1.0 µM, whereas compounds
4
and
9
showed potent inhibition of tyrosinase in a dose-dependent manner, having IC
50
values of 16.8 ± 2.7 and 8.7 ± 2.7 µM, respectively.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00044-017-1975-x</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7272-7290</orcidid></addata></record> |
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| language | eng |
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| source | SpringerLink |
| subjects | Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Epoxide hydrolase Flavonoids NMR Nuclear magnetic resonance Original Research Pharmacology/Toxicology Tyrosinase |
| title | Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities |
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