Design, synthesis, estrogenic and antiestrogenic activities of some triarylpyrazole derivatives

New triarylpyrazole derivatives, substituted with basic side chain, polar group or heterocyclic ring were designed and synthesized. Nineteen compounds were tested for their in vivo uterotrophic activity. Animals treated with compounds 9 , 15a , 15c , 19a , 19f , 20a , and 21b showed pronounced incre...

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Veröffentlicht in:	Medicinal chemistry research 2017-11, Vol.26 (11), p.2785-2808
Hauptverfasser:	Ragab, Mahmoud A., Abd El Razik, Heba A., Afify, Elham A., Ismail, Khadiga A., Khalil, Mounir A., Habib, Nargues S.
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Derivatives Original Research Pharmacology/Toxicology Sex hormones Tamoxifen Uterus Xenoestrogens
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