A widely tunable, near-infrared laser-based trace gas sensor for hydrogen cyanide (HCN) detection in exhaled breath
A compact, cost-effective sensor is developed for detection of hydrogen cyanide (HCN) in exhaled breath within seconds. For this, an off-axis integrated cavity output spectroscopy setup is combined with a widely tunable compact near-infrared laser (tunability 1527–1564 nm). For HCN a detection sensi...
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| Veröffentlicht in: | Applied physics. B, Lasers and optics Lasers and optics, 2017-11, Vol.123 (11), p.1-7, Article 268 |
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| container_title | Applied physics. B, Lasers and optics |
| container_volume | 123 |
| creator | Azhar, M. Mandon, J. Neerincx, A. H. Liu, Z. Mink, J. Merkus, P. J. F. M. Cristescu, S. M. Harren, F. J. M. |
| description | A compact, cost-effective sensor is developed for detection of hydrogen cyanide (HCN) in exhaled breath within seconds. For this, an off-axis integrated cavity output spectroscopy setup is combined with a widely tunable compact near-infrared laser (tunability 1527–1564 nm). For HCN a detection sensitivity has been obtained of 8 ppbv in nitrogen (within 1 s), equal to a noise equivalent absorption sensitivity of 1.9 × 10
−9
cm
−1
Hz
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. With this sensor we demonstrated the presence of HCN in exhaled breath; its detection could be a good indicator for bacterial lung infection. Due to its compact, cost-effective and user-friendly design, this laser-based sensor has the potential to be implemented in future clinical applications. |
| doi_str_mv | 10.1007/s00340-017-6842-4 |
| format | Article |
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−9
cm
−1
Hz
−1/2
. With this sensor we demonstrated the presence of HCN in exhaled breath; its detection could be a good indicator for bacterial lung infection. Due to its compact, cost-effective and user-friendly design, this laser-based sensor has the potential to be implemented in future clinical applications.</description><identifier>ISSN: 0946-2171</identifier><identifier>EISSN: 1432-0649</identifier><identifier>DOI: 10.1007/s00340-017-6842-4</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Applied physics ; Bacteria ; Cyanides ; Engineering ; Gas sensors ; Hydrogen cyanide ; Infrared detectors ; Infrared lasers ; Laser applications ; Lasers ; Near infrared radiation ; Noise sensitivity ; Optical Devices ; Optics ; Photonics ; Physical Chemistry ; Physics ; Physics and Astronomy ; Quantum Optics ; Sensors</subject><ispartof>Applied physics. B, Lasers and optics, 2017-11, Vol.123 (11), p.1-7, Article 268</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-f1c8d9af3e75607f3b84299295448f54f8d73da9ee37aca5a5cf0c65d56bcec03</citedby><cites>FETCH-LOGICAL-c359t-f1c8d9af3e75607f3b84299295448f54f8d73da9ee37aca5a5cf0c65d56bcec03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00340-017-6842-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00340-017-6842-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Azhar, M.</creatorcontrib><creatorcontrib>Mandon, J.</creatorcontrib><creatorcontrib>Neerincx, A. H.</creatorcontrib><creatorcontrib>Liu, Z.</creatorcontrib><creatorcontrib>Mink, J.</creatorcontrib><creatorcontrib>Merkus, P. J. F. M.</creatorcontrib><creatorcontrib>Cristescu, S. M.</creatorcontrib><creatorcontrib>Harren, F. J. M.</creatorcontrib><title>A widely tunable, near-infrared laser-based trace gas sensor for hydrogen cyanide (HCN) detection in exhaled breath</title><title>Applied physics. B, Lasers and optics</title><addtitle>Appl. Phys. B</addtitle><description>A compact, cost-effective sensor is developed for detection of hydrogen cyanide (HCN) in exhaled breath within seconds. For this, an off-axis integrated cavity output spectroscopy setup is combined with a widely tunable compact near-infrared laser (tunability 1527–1564 nm). For HCN a detection sensitivity has been obtained of 8 ppbv in nitrogen (within 1 s), equal to a noise equivalent absorption sensitivity of 1.9 × 10
−9
cm
−1
Hz
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. With this sensor we demonstrated the presence of HCN in exhaled breath; its detection could be a good indicator for bacterial lung infection. Due to its compact, cost-effective and user-friendly design, this laser-based sensor has the potential to be implemented in future clinical applications.</description><subject>Applied physics</subject><subject>Bacteria</subject><subject>Cyanides</subject><subject>Engineering</subject><subject>Gas sensors</subject><subject>Hydrogen cyanide</subject><subject>Infrared detectors</subject><subject>Infrared lasers</subject><subject>Laser applications</subject><subject>Lasers</subject><subject>Near infrared radiation</subject><subject>Noise sensitivity</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Photonics</subject><subject>Physical Chemistry</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Quantum Optics</subject><subject>Sensors</subject><issn>0946-2171</issn><issn>1432-0649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp1kEFLAzEQhYMoWKs_wFvAi4LRZJPsbo6lqBWKXvQcssmk3bJma7JF99-bUg9eHJiZy3vfMA-hS0bvGKXVfaKUC0ooq0hZi4KIIzRhgheElkIdowlVoiQFq9gpOktpQ3OVdT1BaYa_WgfdiIddME0HtziAiaQNPpoIDncmQSRNng4P0VjAK5NwgpD6iH3u9ehiv4KA7WhCRuHrxfzlBjsYwA5tH3AbMHyvTZcBTQQzrM_RiTddgovfPUXvjw9v8wVZvj49z2dLYrlUA_HM1k4Zz6GSJa08b_JjShVKClF7KXztKu6MAuCVsUYaaT21pXSybCxYyqfo6sDdxv5zB2nQm34XQz6pmZKSVnUpeVaxg8rGPqUIXm9j-2HiqBnV-2z1IVuds9X7bLXInuLgSVkbVhD_kP81_QAOUHzE</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Azhar, M.</creator><creator>Mandon, J.</creator><creator>Neerincx, A. H.</creator><creator>Liu, Z.</creator><creator>Mink, J.</creator><creator>Merkus, P. J. F. M.</creator><creator>Cristescu, S. M.</creator><creator>Harren, F. J. M.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20171101</creationdate><title>A widely tunable, near-infrared laser-based trace gas sensor for hydrogen cyanide (HCN) detection in exhaled breath</title><author>Azhar, M. ; Mandon, J. ; Neerincx, A. H. ; Liu, Z. ; Mink, J. ; Merkus, P. J. F. M. ; Cristescu, S. M. ; Harren, F. J. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-f1c8d9af3e75607f3b84299295448f54f8d73da9ee37aca5a5cf0c65d56bcec03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Applied physics</topic><topic>Bacteria</topic><topic>Cyanides</topic><topic>Engineering</topic><topic>Gas sensors</topic><topic>Hydrogen cyanide</topic><topic>Infrared detectors</topic><topic>Infrared lasers</topic><topic>Laser applications</topic><topic>Lasers</topic><topic>Near infrared radiation</topic><topic>Noise sensitivity</topic><topic>Optical Devices</topic><topic>Optics</topic><topic>Photonics</topic><topic>Physical Chemistry</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>Quantum Optics</topic><topic>Sensors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azhar, M.</creatorcontrib><creatorcontrib>Mandon, J.</creatorcontrib><creatorcontrib>Neerincx, A. H.</creatorcontrib><creatorcontrib>Liu, Z.</creatorcontrib><creatorcontrib>Mink, J.</creatorcontrib><creatorcontrib>Merkus, P. J. F. M.</creatorcontrib><creatorcontrib>Cristescu, S. M.</creatorcontrib><creatorcontrib>Harren, F. J. M.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><jtitle>Applied physics. B, Lasers and optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azhar, M.</au><au>Mandon, J.</au><au>Neerincx, A. H.</au><au>Liu, Z.</au><au>Mink, J.</au><au>Merkus, P. J. F. M.</au><au>Cristescu, S. M.</au><au>Harren, F. J. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A widely tunable, near-infrared laser-based trace gas sensor for hydrogen cyanide (HCN) detection in exhaled breath</atitle><jtitle>Applied physics. B, Lasers and optics</jtitle><stitle>Appl. Phys. B</stitle><date>2017-11-01</date><risdate>2017</risdate><volume>123</volume><issue>11</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><artnum>268</artnum><issn>0946-2171</issn><eissn>1432-0649</eissn><abstract>A compact, cost-effective sensor is developed for detection of hydrogen cyanide (HCN) in exhaled breath within seconds. For this, an off-axis integrated cavity output spectroscopy setup is combined with a widely tunable compact near-infrared laser (tunability 1527–1564 nm). For HCN a detection sensitivity has been obtained of 8 ppbv in nitrogen (within 1 s), equal to a noise equivalent absorption sensitivity of 1.9 × 10
−9
cm
−1
Hz
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. With this sensor we demonstrated the presence of HCN in exhaled breath; its detection could be a good indicator for bacterial lung infection. Due to its compact, cost-effective and user-friendly design, this laser-based sensor has the potential to be implemented in future clinical applications.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00340-017-6842-4</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Applied physics. B, Lasers and optics, 2017-11, Vol.123 (11), p.1-7, Article 268 |
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| subjects | Applied physics Bacteria Cyanides Engineering Gas sensors Hydrogen cyanide Infrared detectors Infrared lasers Laser applications Lasers Near infrared radiation Noise sensitivity Optical Devices Optics Photonics Physical Chemistry Physics Physics and Astronomy Quantum Optics Sensors |
| title | A widely tunable, near-infrared laser-based trace gas sensor for hydrogen cyanide (HCN) detection in exhaled breath |
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