Solution‐Phase Synthesis of Branched Oligonucleotides with up to 32 Nucleotides and the Reversible Formation of Materials

A linear solution‐phase synthesis of branched oligonucleotides with adamantane as core has been developed. The method uses conventional phosphoramidites only, achieves chain assembly without chromatography of intermediates, and overcomes the low reactivity of adamantane‐1,3,5,7‐tetraol as core. The...

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Veröffentlicht in:	European journal of organic chemistry 2017-10, Vol.2017 (39), p.5852-5864
Hauptverfasser:	Schwenger, Alexander, Birchall, Nicholas, Richert, Clemens
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantanes Assembly Deoxyribonucleic acid DNA Gene sequencing High performance liquid chromatography Hybrid systems Nucleotides Oligonucleotides Phosphoramidites Synthesis Synthesis design
Online-Zugang:	Volltext
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