Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease

CSF from patients with motor neurone disease (MND) has been reported to be toxic to cultured primary neurones. We found that CSF from MND patients homozygous for the D90A CuZn-superoxide dismutase (CuZn-SOD) mutation, patients with sporadic MND and patients with familial MND without CuZn-SOD mutatio...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2002-04, Vol.125 (Pt 4), p.722-731
Hauptverfasser:	TIKKA, Tiina M, VARTIAINEN, Nina E, GOLDSTEINS, Gundars, OJA, Simo S, ANDERSEN, Peter M, MARKLUND, Stefan L, KOISTINAHO, Jari
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Cells, Cultured Cerebrospinal Fluid Proteins - metabolism Cerebrospinal Fluid Proteins - toxicity Excitatory Amino Acid Antagonists - pharmacology Female Glutamic Acid - metabolism Humans Male Medical sciences Microglia - drug effects Microglia - metabolism Middle Aged Minocycline - pharmacology Minocycline - therapeutic use Motor Neuron Disease - cerebrospinal fluid Motor Neuron Disease - drug therapy Motor Neuron Disease - genetics Motor Neurons - drug effects Motor Neurons - metabolism Motor Neurons - pathology Mutation - genetics Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurotoxins - metabolism Neurotoxins - toxicity Rats Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - physiopathology Superoxide Dismutase - genetics
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