Comparison of the characteristics of Mycobacterium tuberculosis isolates from sputum and lung lesions in chronic tuberculosis patients
Mycobacterium tuberculosis (Mtb) in sputum originates from lung cavities in tuberculosis (TB) patients. But drug susceptibility testing (DST) of sputum Mtb can not be conducted the same as in the lung because mutagenesis of bacilli may be happening in the lung during treatment and result in the poss...
Gespeichert in:
| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2017-11, Vol.36 (11), p.2063-2072 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2072 |
|---|---|
| container_issue | 11 |
| container_start_page | 2063 |
| container_title | European journal of clinical microbiology & infectious diseases |
| container_volume | 36 |
| creator | Hong, M.-S. Kim, Y. Cho, E.-J. Lee, J.-S. Kwak, H.-K. Kim, J.-H. Kim, C.-T. Cho, J.-S. Park, S.-K. Jeon, D. Choi, Y.-I. Lee, H. Eum, S.-Y. |
| description | Mycobacterium tuberculosis
(Mtb) in sputum originates from lung cavities in tuberculosis (TB) patients. But drug susceptibility testing (DST) of sputum Mtb can not be conducted the same as in the lung because mutagenesis of bacilli may be happening in the lung during treatment and result in the possibility of the presence of heterogeneous drug-resistant subpopulations in the different lung lesions. This could be one of the reasons for low cure rates for multi-drug resistant (MDR)-TB. We studied the resected lungs of nine surgery patients with chronic TB. The isolates isolated from the sputum and different lung lesions of each patient were tested for phenotypic DST and genotyped using restriction fragment length polymorphism (RFLP) typing method. Genetic analysis to resistance to first and second line drugs was also performed. Five of nine patients were MDR-TB and three XDR-TB. DST results for ten anti-TB drugs were in accordance among different lung lesions in eight patients. However, only three of these eight patients showed the concordance of DST with sputum. Even though the isolates were heteroresistant, genotyping them by RFLP showed the clonal population in each individual patient. Six of eight followed-up patients achieved successful cure. In conclusion, the heteroresistance between sputum and lung lesions and a clonal population without mixed infection might provide useful information in establishing treatment regimen and surgery decision for MDR- and XDR-TB. |
| doi_str_mv | 10.1007/s10096-017-3025-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1954238413</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1954238413</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-b59fe58632d056abf4e8496ac36ad94bc1a94c9d7a243d30b2854f168196d68b3</originalsourceid><addsrcrecordid>eNp1kMtKxTAURYMoen18gBMJOK7m3WQoF1-gONFxSNNUK21Sk3TgD_jd5lIVHTg5B_ZZex_YABxjdIYRqs9TmUpUCNcVRYRXfAusMKO8YrSm22CFFGWVqgndA_spvaLikXW9C_aIFARJxlbgYx3GycQ-BQ9DB_OLg_bFRGOzK2LubdrI9-82NIs2jzDPjYt2HkLqEyzOwWSXYBfDCNM050IY38Jh9s9wcKkPvlC-xMbge_vXPZncO5_TIdjpzJDc0dc-AE9Xl4_rm-ru4fp2fXFXWVqTXDVcdY5LQUmLuDBNx5xkShhLhWkVayw2ilnV1oYw2lLUEMlZh4XESrRCNvQAnC65Uwxvs0tZv4Y5-vJSY8UZoZJhWii8UDaGlKLr9BT70cR3jZHeNK-X5nVpXm-a17x4Tr6S52Z07Y_ju-oCkAVI5eSfXfz1-t_UT78lkaI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1954238413</pqid></control><display><type>article</type><title>Comparison of the characteristics of Mycobacterium tuberculosis isolates from sputum and lung lesions in chronic tuberculosis patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hong, M.-S. ; Kim, Y. ; Cho, E.-J. ; Lee, J.-S. ; Kwak, H.-K. ; Kim, J.-H. ; Kim, C.-T. ; Cho, J.-S. ; Park, S.-K. ; Jeon, D. ; Choi, Y.-I. ; Lee, H. ; Eum, S.-Y.</creator><creatorcontrib>Hong, M.-S. ; Kim, Y. ; Cho, E.-J. ; Lee, J.-S. ; Kwak, H.-K. ; Kim, J.-H. ; Kim, C.-T. ; Cho, J.-S. ; Park, S.-K. ; Jeon, D. ; Choi, Y.-I. ; Lee, H. ; Eum, S.-Y.</creatorcontrib><description>Mycobacterium tuberculosis
(Mtb) in sputum originates from lung cavities in tuberculosis (TB) patients. But drug susceptibility testing (DST) of sputum Mtb can not be conducted the same as in the lung because mutagenesis of bacilli may be happening in the lung during treatment and result in the possibility of the presence of heterogeneous drug-resistant subpopulations in the different lung lesions. This could be one of the reasons for low cure rates for multi-drug resistant (MDR)-TB. We studied the resected lungs of nine surgery patients with chronic TB. The isolates isolated from the sputum and different lung lesions of each patient were tested for phenotypic DST and genotyped using restriction fragment length polymorphism (RFLP) typing method. Genetic analysis to resistance to first and second line drugs was also performed. Five of nine patients were MDR-TB and three XDR-TB. DST results for ten anti-TB drugs were in accordance among different lung lesions in eight patients. However, only three of these eight patients showed the concordance of DST with sputum. Even though the isolates were heteroresistant, genotyping them by RFLP showed the clonal population in each individual patient. Six of eight followed-up patients achieved successful cure. In conclusion, the heteroresistance between sputum and lung lesions and a clonal population without mixed infection might provide useful information in establishing treatment regimen and surgery decision for MDR- and XDR-TB.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-017-3025-5</identifier><identifier>PMID: 28620844</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Antitubercular Agents - therapeutic use ; Bacilli ; Biomedical and Life Sciences ; Biomedicine ; Drug resistance ; Drug Resistance, Multiple, Bacterial - genetics ; Female ; Gene polymorphism ; Genetic analysis ; Genotyping ; Humans ; Internal Medicine ; Lesions ; Lung - microbiology ; Lung - pathology ; Lungs ; Male ; Medical Microbiology ; Microbial Sensitivity Tests ; Middle Aged ; Mixed infection ; Multidrug resistance ; Mutagenesis ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - drug effects ; Mycobacterium tuberculosis - genetics ; Mycobacterium tuberculosis - isolation & purification ; Original Article ; Patients ; Polymorphism ; Polymorphism, Restriction Fragment Length ; Restriction fragment length polymorphism ; Sputum ; Sputum - microbiology ; Subpopulations ; Surgery ; Tuberculosis ; Tuberculosis, Multidrug-Resistant - drug therapy ; Tuberculosis, Multidrug-Resistant - microbiology ; Tuberculosis, Pulmonary - drug therapy ; Tuberculosis, Pulmonary - microbiology ; Young Adult</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2017-11, Vol.36 (11), p.2063-2072</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>European Journal of Clinical Microbiology & Infectious Diseases is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-b59fe58632d056abf4e8496ac36ad94bc1a94c9d7a243d30b2854f168196d68b3</citedby><cites>FETCH-LOGICAL-c372t-b59fe58632d056abf4e8496ac36ad94bc1a94c9d7a243d30b2854f168196d68b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-017-3025-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-017-3025-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28620844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, M.-S.</creatorcontrib><creatorcontrib>Kim, Y.</creatorcontrib><creatorcontrib>Cho, E.-J.</creatorcontrib><creatorcontrib>Lee, J.-S.</creatorcontrib><creatorcontrib>Kwak, H.-K.</creatorcontrib><creatorcontrib>Kim, J.-H.</creatorcontrib><creatorcontrib>Kim, C.-T.</creatorcontrib><creatorcontrib>Cho, J.-S.</creatorcontrib><creatorcontrib>Park, S.-K.</creatorcontrib><creatorcontrib>Jeon, D.</creatorcontrib><creatorcontrib>Choi, Y.-I.</creatorcontrib><creatorcontrib>Lee, H.</creatorcontrib><creatorcontrib>Eum, S.-Y.</creatorcontrib><title>Comparison of the characteristics of Mycobacterium tuberculosis isolates from sputum and lung lesions in chronic tuberculosis patients</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Mycobacterium tuberculosis
(Mtb) in sputum originates from lung cavities in tuberculosis (TB) patients. But drug susceptibility testing (DST) of sputum Mtb can not be conducted the same as in the lung because mutagenesis of bacilli may be happening in the lung during treatment and result in the possibility of the presence of heterogeneous drug-resistant subpopulations in the different lung lesions. This could be one of the reasons for low cure rates for multi-drug resistant (MDR)-TB. We studied the resected lungs of nine surgery patients with chronic TB. The isolates isolated from the sputum and different lung lesions of each patient were tested for phenotypic DST and genotyped using restriction fragment length polymorphism (RFLP) typing method. Genetic analysis to resistance to first and second line drugs was also performed. Five of nine patients were MDR-TB and three XDR-TB. DST results for ten anti-TB drugs were in accordance among different lung lesions in eight patients. However, only three of these eight patients showed the concordance of DST with sputum. Even though the isolates were heteroresistant, genotyping them by RFLP showed the clonal population in each individual patient. Six of eight followed-up patients achieved successful cure. In conclusion, the heteroresistance between sputum and lung lesions and a clonal population without mixed infection might provide useful information in establishing treatment regimen and surgery decision for MDR- and XDR-TB.</description><subject>Adult</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Bacilli</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic analysis</subject><subject>Genotyping</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lesions</subject><subject>Lung - microbiology</subject><subject>Lung - pathology</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Mixed infection</subject><subject>Multidrug resistance</subject><subject>Mutagenesis</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Original Article</subject><subject>Patients</subject><subject>Polymorphism</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Restriction fragment length polymorphism</subject><subject>Sputum</subject><subject>Sputum - microbiology</subject><subject>Subpopulations</subject><subject>Surgery</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Multidrug-Resistant - drug therapy</subject><subject>Tuberculosis, Multidrug-Resistant - microbiology</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><subject>Tuberculosis, Pulmonary - microbiology</subject><subject>Young Adult</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMtKxTAURYMoen18gBMJOK7m3WQoF1-gONFxSNNUK21Sk3TgD_jd5lIVHTg5B_ZZex_YABxjdIYRqs9TmUpUCNcVRYRXfAusMKO8YrSm22CFFGWVqgndA_spvaLikXW9C_aIFARJxlbgYx3GycQ-BQ9DB_OLg_bFRGOzK2LubdrI9-82NIs2jzDPjYt2HkLqEyzOwWSXYBfDCNM050IY38Jh9s9wcKkPvlC-xMbge_vXPZncO5_TIdjpzJDc0dc-AE9Xl4_rm-ru4fp2fXFXWVqTXDVcdY5LQUmLuDBNx5xkShhLhWkVayw2ilnV1oYw2lLUEMlZh4XESrRCNvQAnC65Uwxvs0tZv4Y5-vJSY8UZoZJhWii8UDaGlKLr9BT70cR3jZHeNK-X5nVpXm-a17x4Tr6S52Z07Y_ju-oCkAVI5eSfXfz1-t_UT78lkaI</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Hong, M.-S.</creator><creator>Kim, Y.</creator><creator>Cho, E.-J.</creator><creator>Lee, J.-S.</creator><creator>Kwak, H.-K.</creator><creator>Kim, J.-H.</creator><creator>Kim, C.-T.</creator><creator>Cho, J.-S.</creator><creator>Park, S.-K.</creator><creator>Jeon, D.</creator><creator>Choi, Y.-I.</creator><creator>Lee, H.</creator><creator>Eum, S.-Y.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20171101</creationdate><title>Comparison of the characteristics of Mycobacterium tuberculosis isolates from sputum and lung lesions in chronic tuberculosis patients</title><author>Hong, M.-S. ; Kim, Y. ; Cho, E.-J. ; Lee, J.-S. ; Kwak, H.-K. ; Kim, J.-H. ; Kim, C.-T. ; Cho, J.-S. ; Park, S.-K. ; Jeon, D. ; Choi, Y.-I. ; Lee, H. ; Eum, S.-Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-b59fe58632d056abf4e8496ac36ad94bc1a94c9d7a243d30b2854f168196d68b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Bacilli</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genetic analysis</topic><topic>Genotyping</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lesions</topic><topic>Lung - microbiology</topic><topic>Lung - pathology</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Mixed infection</topic><topic>Multidrug resistance</topic><topic>Mutagenesis</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Mycobacterium tuberculosis - isolation & purification</topic><topic>Original Article</topic><topic>Patients</topic><topic>Polymorphism</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Restriction fragment length polymorphism</topic><topic>Sputum</topic><topic>Sputum - microbiology</topic><topic>Subpopulations</topic><topic>Surgery</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Multidrug-Resistant - drug therapy</topic><topic>Tuberculosis, Multidrug-Resistant - microbiology</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><topic>Tuberculosis, Pulmonary - microbiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, M.-S.</creatorcontrib><creatorcontrib>Kim, Y.</creatorcontrib><creatorcontrib>Cho, E.-J.</creatorcontrib><creatorcontrib>Lee, J.-S.</creatorcontrib><creatorcontrib>Kwak, H.-K.</creatorcontrib><creatorcontrib>Kim, J.-H.</creatorcontrib><creatorcontrib>Kim, C.-T.</creatorcontrib><creatorcontrib>Cho, J.-S.</creatorcontrib><creatorcontrib>Park, S.-K.</creatorcontrib><creatorcontrib>Jeon, D.</creatorcontrib><creatorcontrib>Choi, Y.-I.</creatorcontrib><creatorcontrib>Lee, H.</creatorcontrib><creatorcontrib>Eum, S.-Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, M.-S.</au><au>Kim, Y.</au><au>Cho, E.-J.</au><au>Lee, J.-S.</au><au>Kwak, H.-K.</au><au>Kim, J.-H.</au><au>Kim, C.-T.</au><au>Cho, J.-S.</au><au>Park, S.-K.</au><au>Jeon, D.</au><au>Choi, Y.-I.</au><au>Lee, H.</au><au>Eum, S.-Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the characteristics of Mycobacterium tuberculosis isolates from sputum and lung lesions in chronic tuberculosis patients</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>36</volume><issue>11</issue><spage>2063</spage><epage>2072</epage><pages>2063-2072</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Mycobacterium tuberculosis
(Mtb) in sputum originates from lung cavities in tuberculosis (TB) patients. But drug susceptibility testing (DST) of sputum Mtb can not be conducted the same as in the lung because mutagenesis of bacilli may be happening in the lung during treatment and result in the possibility of the presence of heterogeneous drug-resistant subpopulations in the different lung lesions. This could be one of the reasons for low cure rates for multi-drug resistant (MDR)-TB. We studied the resected lungs of nine surgery patients with chronic TB. The isolates isolated from the sputum and different lung lesions of each patient were tested for phenotypic DST and genotyped using restriction fragment length polymorphism (RFLP) typing method. Genetic analysis to resistance to first and second line drugs was also performed. Five of nine patients were MDR-TB and three XDR-TB. DST results for ten anti-TB drugs were in accordance among different lung lesions in eight patients. However, only three of these eight patients showed the concordance of DST with sputum. Even though the isolates were heteroresistant, genotyping them by RFLP showed the clonal population in each individual patient. Six of eight followed-up patients achieved successful cure. In conclusion, the heteroresistance between sputum and lung lesions and a clonal population without mixed infection might provide useful information in establishing treatment regimen and surgery decision for MDR- and XDR-TB.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28620844</pmid><doi>10.1007/s10096-017-3025-5</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2017-11, Vol.36 (11), p.2063-2072 |
| issn | 0934-9723 1435-4373 |
| language | eng |
| recordid | cdi_proquest_journals_1954238413 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Antitubercular Agents - therapeutic use Bacilli Biomedical and Life Sciences Biomedicine Drug resistance Drug Resistance, Multiple, Bacterial - genetics Female Gene polymorphism Genetic analysis Genotyping Humans Internal Medicine Lesions Lung - microbiology Lung - pathology Lungs Male Medical Microbiology Microbial Sensitivity Tests Middle Aged Mixed infection Multidrug resistance Mutagenesis Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Original Article Patients Polymorphism Polymorphism, Restriction Fragment Length Restriction fragment length polymorphism Sputum Sputum - microbiology Subpopulations Surgery Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - microbiology Young Adult |
| title | Comparison of the characteristics of Mycobacterium tuberculosis isolates from sputum and lung lesions in chronic tuberculosis patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T13%3A44%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20the%20characteristics%20of%20Mycobacterium%20tuberculosis%20isolates%20from%20sputum%20and%20lung%20lesions%20in%20chronic%20tuberculosis%20patients&rft.jtitle=European%20journal%20of%20clinical%20microbiology%20&%20infectious%20diseases&rft.au=Hong,%20M.-S.&rft.date=2017-11-01&rft.volume=36&rft.issue=11&rft.spage=2063&rft.epage=2072&rft.pages=2063-2072&rft.issn=0934-9723&rft.eissn=1435-4373&rft_id=info:doi/10.1007/s10096-017-3025-5&rft_dat=%3Cproquest_cross%3E1954238413%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1954238413&rft_id=info:pmid/28620844&rfr_iscdi=true |