Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in DICER1 syndrome: a unique variant of the two-hit tumor suppression model [version 1; peer review: 2 approved with reservations]

Pleuropulmonary blastoma (PPB) is the most frequent pediatric lung tumor and often the first indication of a pleiotropic cancer predisposition,  DICER1 syndrome, comprising a range of other individually rare, benign and malignant tumors of childhood and early adulthood. The genetics of  DICER1-assoc...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	F1000 research 2015, Vol.4, p.214
Hauptverfasser:	Brenneman, Mark, Field, Amanda, Yang, Jiandong, Williams, Gretchen, Doros, Leslie, Rossi, Christopher, Schultz, Kris Ann, Rosenberg, Avi, Ivanovich, Jennifer, Turner, Joyce, Gordish-Dressman, Heather, Stewart, Douglas, Yu, Weiying, Harris, Anne, Schoettler, Peter, Goodfellow, Paul, Dehner, Louis, Messinger, Yoav, Hill, D. Ashley
Format:	Artikel
Sprache:	eng
Schlagworte:	Lung Cancer Mutation hot spots Pediatric Oncology Tumor suppression
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!