Curcumin-encapsulated polymeric nanoparticles for metastatic osteosarcoma cells treatment
Osteosarcoma is a high-class malignant bone cancer with a less than 20% five-year survival rate due to its early metastasis potential. There is an urgent need to develop a versatile and innoxious drug to treat metastatic osteosarcoma. Curcumin (Cur) has shown its potential for the treatment of many...
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| Veröffentlicht in: | Science China materials 2017-10, Vol.60 (10), p.995-1007 |
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| creator | Wang, Guanyi Song, Wantong Shen, Na Yu, Haiyang Deng, Mingxiao Tang, Zhaohui Fu, Xueqi Chen, Xuesi |
| description | Osteosarcoma is a high-class malignant bone cancer with a less than 20% five-year survival rate due to its early metastasis potential. There is an urgent need to develop a versatile and innoxious drug to treat metastatic osteosarcoma. Curcumin (Cur) has shown its potential for the treatment of many cancers; however, the clinical implication of native curcumin is severely hindered by its intrinsic property. In this study, a mixed system of monomethoxy (polyethylene glycol)-poly(d, l-lactide-co-glycolide)/poly(ε-caprolactone) (mPEG-PLGA/PCL) was used to build a formulation of curcumin-encapsulated nanoparticles (Cur-NPs), which significantly improved the solubility, stability and cellular uptake of curcumin. Moreover, the Cur-NPs were superior to free curcumin in the matter of inhibition on the proliferation, migration and invasion of osteosarcoma 143B cells. It was found that both free curcumin and Cur-NPs could decrease the expressions of c-Myc and MMP7 in the level of mRNA and protein, which explained why free curcumin and Cur-NPs could inhibit the proliferation and invasion of metastatic osteosarcoma 143B cells. The Cur-NPs provided a promising strategy for metastatic osteosarcoma treatment. |
| doi_str_mv | 10.1007/s40843-017-9107-x |
| format | Article |
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There is an urgent need to develop a versatile and innoxious drug to treat metastatic osteosarcoma. Curcumin (Cur) has shown its potential for the treatment of many cancers; however, the clinical implication of native curcumin is severely hindered by its intrinsic property. In this study, a mixed system of monomethoxy (polyethylene glycol)-poly(d, l-lactide-co-glycolide)/poly(ε-caprolactone) (mPEG-PLGA/PCL) was used to build a formulation of curcumin-encapsulated nanoparticles (Cur-NPs), which significantly improved the solubility, stability and cellular uptake of curcumin. Moreover, the Cur-NPs were superior to free curcumin in the matter of inhibition on the proliferation, migration and invasion of osteosarcoma 143B cells. It was found that both free curcumin and Cur-NPs could decrease the expressions of c-Myc and MMP7 in the level of mRNA and protein, which explained why free curcumin and Cur-NPs could inhibit the proliferation and invasion of metastatic osteosarcoma 143B cells. The Cur-NPs provided a promising strategy for metastatic osteosarcoma treatment.</description><identifier>ISSN: 2095-8226</identifier><identifier>EISSN: 2199-4501</identifier><identifier>DOI: 10.1007/s40843-017-9107-x</identifier><language>eng</language><publisher>Beijing: Science China Press</publisher><subject>Biocompatibility ; Bone cancer ; Chemistry and Materials Science ; Chemistry/Food Science ; Encapsulation ; Materials Science ; Metastasis ; MPEG encoders ; Nanoparticles ; Polyethylene glycol ; Polyethylenes ; Video compression</subject><ispartof>Science China materials, 2017-10, Vol.60 (10), p.995-1007</ispartof><rights>Science China Press and Springer-Verlag GmbH Germany 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-b7b814bc45a9355a99c857120097127ac860092c790b2a7c12c0c3871364f3563</citedby><cites>FETCH-LOGICAL-c359t-b7b814bc45a9355a99c857120097127ac860092c790b2a7c12c0c3871364f3563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40843-017-9107-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40843-017-9107-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Wang, Guanyi</creatorcontrib><creatorcontrib>Song, Wantong</creatorcontrib><creatorcontrib>Shen, Na</creatorcontrib><creatorcontrib>Yu, Haiyang</creatorcontrib><creatorcontrib>Deng, Mingxiao</creatorcontrib><creatorcontrib>Tang, Zhaohui</creatorcontrib><creatorcontrib>Fu, Xueqi</creatorcontrib><creatorcontrib>Chen, Xuesi</creatorcontrib><title>Curcumin-encapsulated polymeric nanoparticles for metastatic osteosarcoma cells treatment</title><title>Science China materials</title><addtitle>Sci. China Mater</addtitle><description>Osteosarcoma is a high-class malignant bone cancer with a less than 20% five-year survival rate due to its early metastasis potential. There is an urgent need to develop a versatile and innoxious drug to treat metastatic osteosarcoma. Curcumin (Cur) has shown its potential for the treatment of many cancers; however, the clinical implication of native curcumin is severely hindered by its intrinsic property. In this study, a mixed system of monomethoxy (polyethylene glycol)-poly(d, l-lactide-co-glycolide)/poly(ε-caprolactone) (mPEG-PLGA/PCL) was used to build a formulation of curcumin-encapsulated nanoparticles (Cur-NPs), which significantly improved the solubility, stability and cellular uptake of curcumin. Moreover, the Cur-NPs were superior to free curcumin in the matter of inhibition on the proliferation, migration and invasion of osteosarcoma 143B cells. It was found that both free curcumin and Cur-NPs could decrease the expressions of c-Myc and MMP7 in the level of mRNA and protein, which explained why free curcumin and Cur-NPs could inhibit the proliferation and invasion of metastatic osteosarcoma 143B cells. The Cur-NPs provided a promising strategy for metastatic osteosarcoma treatment.</description><subject>Biocompatibility</subject><subject>Bone cancer</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Encapsulation</subject><subject>Materials Science</subject><subject>Metastasis</subject><subject>MPEG encoders</subject><subject>Nanoparticles</subject><subject>Polyethylene glycol</subject><subject>Polyethylenes</subject><subject>Video compression</subject><issn>2095-8226</issn><issn>2199-4501</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LxDAQxYMouKz7AbwVPEdnkqZpjrL4Dxa86MFTSGMqXdqmJinsfnuz1IMXL2-G4b038CPkGuEWAeRdLKEuOQWUVCFIejgjK4ZK0VIAnucdlKA1Y9Ul2cS4BwCsBKKqV-RjOwc7D91I3WjNFOfeJPdZTL4_Di50thjN6CcTUmd7F4vWh2JwycRk8qXwMTkfTbB-MIV1fR-LFJxJgxvTFbloTR_d5neuyfvjw9v2me5en1629ztquVCJNrKpsWxsKYziIouytZDIAFRWaWxd5ZVZqaBhRlpkFiyvJfKqbLmo-JrcLL1T8N-zi0nv_RzG_FKjEkzIUmQ4a4KLywYfY3CtnkI3mHDUCPoEUS8QdYaoTxD1IWfYkonZO3658Kf539APGIR1Yg</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Wang, Guanyi</creator><creator>Song, Wantong</creator><creator>Shen, Na</creator><creator>Yu, Haiyang</creator><creator>Deng, Mingxiao</creator><creator>Tang, Zhaohui</creator><creator>Fu, Xueqi</creator><creator>Chen, Xuesi</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20171001</creationdate><title>Curcumin-encapsulated polymeric nanoparticles for metastatic osteosarcoma cells treatment</title><author>Wang, Guanyi ; Song, Wantong ; Shen, Na ; Yu, Haiyang ; Deng, Mingxiao ; Tang, Zhaohui ; Fu, Xueqi ; Chen, Xuesi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-b7b814bc45a9355a99c857120097127ac860092c790b2a7c12c0c3871364f3563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biocompatibility</topic><topic>Bone cancer</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Encapsulation</topic><topic>Materials Science</topic><topic>Metastasis</topic><topic>MPEG encoders</topic><topic>Nanoparticles</topic><topic>Polyethylene glycol</topic><topic>Polyethylenes</topic><topic>Video compression</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Guanyi</creatorcontrib><creatorcontrib>Song, Wantong</creatorcontrib><creatorcontrib>Shen, Na</creatorcontrib><creatorcontrib>Yu, Haiyang</creatorcontrib><creatorcontrib>Deng, Mingxiao</creatorcontrib><creatorcontrib>Tang, Zhaohui</creatorcontrib><creatorcontrib>Fu, Xueqi</creatorcontrib><creatorcontrib>Chen, Xuesi</creatorcontrib><collection>CrossRef</collection><jtitle>Science China materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Guanyi</au><au>Song, Wantong</au><au>Shen, Na</au><au>Yu, Haiyang</au><au>Deng, Mingxiao</au><au>Tang, Zhaohui</au><au>Fu, Xueqi</au><au>Chen, Xuesi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curcumin-encapsulated polymeric nanoparticles for metastatic osteosarcoma cells treatment</atitle><jtitle>Science China materials</jtitle><stitle>Sci. China Mater</stitle><date>2017-10-01</date><risdate>2017</risdate><volume>60</volume><issue>10</issue><spage>995</spage><epage>1007</epage><pages>995-1007</pages><issn>2095-8226</issn><eissn>2199-4501</eissn><abstract>Osteosarcoma is a high-class malignant bone cancer with a less than 20% five-year survival rate due to its early metastasis potential. There is an urgent need to develop a versatile and innoxious drug to treat metastatic osteosarcoma. Curcumin (Cur) has shown its potential for the treatment of many cancers; however, the clinical implication of native curcumin is severely hindered by its intrinsic property. In this study, a mixed system of monomethoxy (polyethylene glycol)-poly(d, l-lactide-co-glycolide)/poly(ε-caprolactone) (mPEG-PLGA/PCL) was used to build a formulation of curcumin-encapsulated nanoparticles (Cur-NPs), which significantly improved the solubility, stability and cellular uptake of curcumin. Moreover, the Cur-NPs were superior to free curcumin in the matter of inhibition on the proliferation, migration and invasion of osteosarcoma 143B cells. It was found that both free curcumin and Cur-NPs could decrease the expressions of c-Myc and MMP7 in the level of mRNA and protein, which explained why free curcumin and Cur-NPs could inhibit the proliferation and invasion of metastatic osteosarcoma 143B cells. The Cur-NPs provided a promising strategy for metastatic osteosarcoma treatment.</abstract><cop>Beijing</cop><pub>Science China Press</pub><doi>10.1007/s40843-017-9107-x</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biocompatibility Bone cancer Chemistry and Materials Science Chemistry/Food Science Encapsulation Materials Science Metastasis MPEG encoders Nanoparticles Polyethylene glycol Polyethylenes Video compression |
| title | Curcumin-encapsulated polymeric nanoparticles for metastatic osteosarcoma cells treatment |
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