A Multiscale Fabrication Approach to Microfluidic System Development
Microfluidic systems for analytical, medical, and sensing applications integrate optical or electrical readouts in lowcost, low-volume consumption systems. Embedding chemically functionalized templates with nanoscale topography within these devices links the scale at which molecular recognition/ sel...
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| Veröffentlicht in: | Journal of manufacturing processes 2004, Vol.6 (1), p.88-96 |
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| creator | Schmitz, T.L. Dagata, J.A. Dutterer, B. Sawyer, W. Gregory |
| description | Microfluidic systems for analytical, medical, and sensing applications integrate optical or electrical readouts in lowcost, low-volume consumption systems. Embedding chemically functionalized templates with nanoscale topography within these devices links the scale at which molecular recognition/ self-organization occurs and the macroscopic layout of fluid channels, mixing volumes, and detection regions. Although the design of a platform that would meet the needs of all microfluidic experiments is a difficult undertaking, this paper provides a description of a flexure-based platform that may address generic requirements such as low cost, ease of manufacture, and repeatable alignment/sealing performance. Experimental results are provided for master replication in plastics by hot embossing and a microfluidic platform that orients 125 micrometer channels embossed in a poly(vinyl chloride) gasket to an array of high-speed machined channels. |
| doi_str_mv | 10.1016/S1526-6125(04)70062-6 |
| format | Article |
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| identifier | ISSN: 1526-6125 |
| ispartof | Journal of manufacturing processes, 2004, Vol.6 (1), p.88-96 |
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| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Design Flexure High speed machining Hot Embossing Laboratories Manufacturing Operations research Polymers Silicon wafers Studies Systems development |
| title | A Multiscale Fabrication Approach to Microfluidic System Development |
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