Exact mass measurements using a 7 tesla fourier transform ion cyclotron resonance mass spectrometer in a good laboratory practices-regulated environment
Fourier transform ion cyclotron resonance mass spectrometry has been found to produce reliable exact mass measurements using two different internal calibration methods. For these measurements, electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) were utilized both in...
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| Veröffentlicht in: | Journal of the American Society for Mass Spectrometry 1999-12, Vol.10 (12), p.1291-1297 |
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| container_title | Journal of the American Society for Mass Spectrometry |
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| creator | Burton, Richard D. Matuszak, Kenneth P. Watson, Clifford H. Eyler, John R. |
| description | Fourier transform ion cyclotron resonance mass spectrometry has been found to produce reliable exact mass measurements using two different internal calibration methods. For these measurements, electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) were utilized both individually and in tandem. For internal calibration with a co-dissolved polyethylene glycol standard, measurements of 41 compounds resulted in an average absolute mass determination error of 0.7 ppm, with a standard deviation of 0.9 ppm. For comparison, internal calibration was effected through the simultaneous use of ESI and MALDI, with the former being used for the introduction of analyte ions and the latter for formation of polymethylmethacrylate calibrant ions. This technique led to mass measurements with an average absolute error of 0.8 ppm and a standard deviation of 1.0 ppm. In addition, exact mass measurements of tandem mass spectrometry fragment ions were made for 35 compounds using external calibration with a single internal mass standard. The observed average absolute error was 0.7 ppm with a standard deviation of 1.0 ppm. |
| doi_str_mv | 10.1016/S1044-0305(99)00106-3 |
| format | Article |
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For these measurements, electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) were utilized both individually and in tandem. For internal calibration with a co-dissolved polyethylene glycol standard, measurements of 41 compounds resulted in an average absolute mass determination error of 0.7 ppm, with a standard deviation of 0.9 ppm. For comparison, internal calibration was effected through the simultaneous use of ESI and MALDI, with the former being used for the introduction of analyte ions and the latter for formation of polymethylmethacrylate calibrant ions. This technique led to mass measurements with an average absolute error of 0.8 ppm and a standard deviation of 1.0 ppm. In addition, exact mass measurements of tandem mass spectrometry fragment ions were made for 35 compounds using external calibration with a single internal mass standard. 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For these measurements, electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) were utilized both individually and in tandem. For internal calibration with a co-dissolved polyethylene glycol standard, measurements of 41 compounds resulted in an average absolute mass determination error of 0.7 ppm, with a standard deviation of 0.9 ppm. For comparison, internal calibration was effected through the simultaneous use of ESI and MALDI, with the former being used for the introduction of analyte ions and the latter for formation of polymethylmethacrylate calibrant ions. This technique led to mass measurements with an average absolute error of 0.8 ppm and a standard deviation of 1.0 ppm. In addition, exact mass measurements of tandem mass spectrometry fragment ions were made for 35 compounds using external calibration with a single internal mass standard. The observed average absolute error was 0.7 ppm with a standard deviation of 1.0 ppm.</description><subject>Analytical chemistry</subject><subject>Calibration</subject><subject>Chemistry</subject><subject>Cyclotron resonance</subject><subject>Desorption</subject><subject>Error analysis</subject><subject>Errors</subject><subject>Exact sciences and technology</subject><subject>Fourier transforms</subject><subject>Ionization</subject><subject>Ions</subject><subject>Lasers</subject><subject>Mass spectrometry</subject><subject>Measurement methods</subject><subject>Polyethylene glycol</subject><subject>Polyethylenes</subject><subject>Scientific imaging</subject><subject>Spectrometric and optical methods</subject><subject>Spectroscopy</subject><subject>Standard deviation</subject><issn>1044-0305</issn><issn>1879-1123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc1u1TAQhSMEEqXwCEiWYAGLgB3_xSuEqkIrVWIBrC3HmVy5SuKLx6l634THZW5vEUtWHlnfOTNzpmleC_5BcGE-fhdcqZZLrt85955zwU0rnzRnoreuFaKTT6n-izxvXiDeEmS5s2fN78v7ECtbAiJbIOBWYIG1ItswrTsWmGUVcA5syltJUFgtYcUpl4WlvLJ4iHOuhaoCmNewRjh54R4i_S9QSZNWMtrlPLI5DLmEmsuB7Qs1ThGwLbDb5lBhZLDeJTI7TvCyeTaFGeHV43ve_Pxy-ePiqr359vX64vNNG6VRtR2EcCqKYHqnLddGUyBdr2FQFngPMZognAxWTBakVjp0ZuhkNGawIydQnjdvTr77kn9tgNXf0qYrtfTC6U5JqXpBlD5RsWTEApPfl7SEcvCC--MR_MMR_DFh75x_OIKXpHv76B4whnmi8GLCf-JOuM4owj6dMKBN7yhmjzEBhTmmQjn6Maf_NPoDJ_2dtA</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>Burton, Richard D.</creator><creator>Matuszak, Kenneth P.</creator><creator>Watson, Clifford H.</creator><creator>Eyler, John R.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>Springer Nature B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>19991201</creationdate><title>Exact mass measurements using a 7 tesla fourier transform ion cyclotron resonance mass spectrometer in a good laboratory practices-regulated environment</title><author>Burton, Richard D. ; 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For these measurements, electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) were utilized both individually and in tandem. For internal calibration with a co-dissolved polyethylene glycol standard, measurements of 41 compounds resulted in an average absolute mass determination error of 0.7 ppm, with a standard deviation of 0.9 ppm. For comparison, internal calibration was effected through the simultaneous use of ESI and MALDI, with the former being used for the introduction of analyte ions and the latter for formation of polymethylmethacrylate calibrant ions. This technique led to mass measurements with an average absolute error of 0.8 ppm and a standard deviation of 1.0 ppm. In addition, exact mass measurements of tandem mass spectrometry fragment ions were made for 35 compounds using external calibration with a single internal mass standard. The observed average absolute error was 0.7 ppm with a standard deviation of 1.0 ppm.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><doi>10.1016/S1044-0305(99)00106-3</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1044-0305 1879-1123 |
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| source | SpringerNature Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Analytical chemistry Calibration Chemistry Cyclotron resonance Desorption Error analysis Errors Exact sciences and technology Fourier transforms Ionization Ions Lasers Mass spectrometry Measurement methods Polyethylene glycol Polyethylenes Scientific imaging Spectrometric and optical methods Spectroscopy Standard deviation |
| title | Exact mass measurements using a 7 tesla fourier transform ion cyclotron resonance mass spectrometer in a good laboratory practices-regulated environment |
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