Comparison of Seizure Duration, Ictal EEG, and Cognitive Effects of Ketamine and Methohexital Anesthesia With ECT
The authors retrospectively compared the seizure duration, ictal EEG, and cognitive side effects of ketamine and methohexital anesthesia with ECT. This comparison was carried out with data from consecutive index ECT treatments that occurred immediately before and after a switch from methohexital to...
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| Veröffentlicht in: | The journal of neuropsychiatry and clinical neurosciences 2003, Vol.15 (1), p.27-34 |
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| container_title | The journal of neuropsychiatry and clinical neurosciences |
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| creator | Krystal, Andrew D Weiner, Richard D Dean, Margaret D Lindahl, Virginia H Tramontozzi III, Louis A Falcone, Grace Coffey, C. Edward |
| description | The authors retrospectively compared the seizure duration, ictal EEG, and cognitive side effects of ketamine and methohexital anesthesia with ECT. This comparison was carried out with data from consecutive index ECT treatments that occurred immediately before and after a switch from methohexital to ketamine in 36 patients. Ketamine was well tolerated and prolonged seizure duration overall, but particularly in those who had a seizure duration shorter than 25 seconds with methohexital at the maximum available stimulus intensity. Ketamine also increased midictal EEG slow-wave amplitude. Thus, a switch to ketamine may be useful when it is difficult to elicit a robust seizure. Faster post-treatment reorientation with ketamine may suggest a lower level of associated cognitive side effects. |
| doi_str_mv | 10.1176/jnp.15.1.27 |
| format | Article |
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Faster post-treatment reorientation with ketamine may suggest a lower level of associated cognitive side effects.</description><identifier>ISSN: 0895-0172</identifier><identifier>EISSN: 1545-7222</identifier><identifier>DOI: 10.1176/jnp.15.1.27</identifier><identifier>PMID: 12556568</identifier><identifier>CODEN: JNCNE7</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Aged ; Aged, 80 and over ; Anesthesia, Intravenous ; Anesthetics. Neuromuscular blocking agents ; Biological and medical sciences ; Bipolar Disorder - therapy ; Depressive Disorder, Major - therapy ; Electroconvulsive Therapy ; Electroencephalography - drug effects ; Female ; Humans ; Ketamine - adverse effects ; Male ; Medical sciences ; Methohexital - administration & dosage ; Middle Aged ; Neuropharmacology ; Orientation - drug effects ; Pharmacology. Drug treatments ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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Edward</creatorcontrib><title>Comparison of Seizure Duration, Ictal EEG, and Cognitive Effects of Ketamine and Methohexital Anesthesia With ECT</title><title>The journal of neuropsychiatry and clinical neurosciences</title><addtitle>J Neuropsychiatry Clin Neurosci</addtitle><description>The authors retrospectively compared the seizure duration, ictal EEG, and cognitive side effects of ketamine and methohexital anesthesia with ECT. This comparison was carried out with data from consecutive index ECT treatments that occurred immediately before and after a switch from methohexital to ketamine in 36 patients. Ketamine was well tolerated and prolonged seizure duration overall, but particularly in those who had a seizure duration shorter than 25 seconds with methohexital at the maximum available stimulus intensity. Ketamine also increased midictal EEG slow-wave amplitude. Thus, a switch to ketamine may be useful when it is difficult to elicit a robust seizure. Faster post-treatment reorientation with ketamine may suggest a lower level of associated cognitive side effects.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia, Intravenous</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - therapy</subject><subject>Depressive Disorder, Major - therapy</subject><subject>Electroconvulsive Therapy</subject><subject>Electroencephalography - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Ketamine - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methohexital - administration & dosage</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Orientation - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychotic Disorders - therapy</subject><subject>Retrospective Studies</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Treatments</subject><issn>0895-0172</issn><issn>1545-7222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0MGL1DAUBvAgijuunrxLEATB7ZikTZMel1rXxRUPrngMr-mLk2Em7SapqH-9HWdgPXh6l9_73uMj5Dlna85V_XYbpjWXa74W6gFZcVnJQgkhHpIV040sGFfijDxJacsYE2VdPSZnXEhZy1qvyF077ieIPo2Bjo5-Qf97jkjfzRGyH8MFvbYZdrTrri4ohIG24_fgs_-BtHMObU6HrY-YYe8D_hWfMG_GDf70h73LgClvMHmg33ze0K69fUoeOdglfHaa5-Tr--62_VDcfL66bi9vChANy4V0TDlV1U5Wva5UhUNT97rXAq0YZKNKJrgDxAF6AG1B95UF1EqXVpc4iPKcvDzmTnG8m5c3zHacY1hOGt5IIaqlpAW9OSIbx5QiOjNFv4f4y3BmDu2apV3DpeFGqEW_OEXO_R6He3uqcwGvTgCShZ2LEKxP966SJWP1Iej10cE0-X_--s_NP9-1j7A</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Krystal, Andrew D</creator><creator>Weiner, Richard D</creator><creator>Dean, Margaret D</creator><creator>Lindahl, Virginia H</creator><creator>Tramontozzi III, Louis A</creator><creator>Falcone, Grace</creator><creator>Coffey, C. Edward</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Press</general><general>American Psychiatric Publishing, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>2003</creationdate><title>Comparison of Seizure Duration, Ictal EEG, and Cognitive Effects of Ketamine and Methohexital Anesthesia With ECT</title><author>Krystal, Andrew D ; Weiner, Richard D ; Dean, Margaret D ; Lindahl, Virginia H ; Tramontozzi III, Louis A ; Falcone, Grace ; Coffey, C. Edward</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a290t-5f07f746f54b8474ed96b8b82ec2d5973021faeedabaa8ca8b4cae8783c83ed23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia, Intravenous</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - therapy</topic><topic>Depressive Disorder, Major - therapy</topic><topic>Electroconvulsive Therapy</topic><topic>Electroencephalography - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Ketamine - adverse effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methohexital - administration & dosage</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Orientation - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychotic Disorders - therapy</topic><topic>Retrospective Studies</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krystal, Andrew D</creatorcontrib><creatorcontrib>Weiner, Richard D</creatorcontrib><creatorcontrib>Dean, Margaret D</creatorcontrib><creatorcontrib>Lindahl, Virginia H</creatorcontrib><creatorcontrib>Tramontozzi III, Louis A</creatorcontrib><creatorcontrib>Falcone, Grace</creatorcontrib><creatorcontrib>Coffey, C. 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Ketamine was well tolerated and prolonged seizure duration overall, but particularly in those who had a seizure duration shorter than 25 seconds with methohexital at the maximum available stimulus intensity. Ketamine also increased midictal EEG slow-wave amplitude. Thus, a switch to ketamine may be useful when it is difficult to elicit a robust seizure. Faster post-treatment reorientation with ketamine may suggest a lower level of associated cognitive side effects.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>12556568</pmid><doi>10.1176/jnp.15.1.27</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); Psychiatry Legacy Collection Online Journals 1844-1996; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Aged, 80 and over Anesthesia, Intravenous Anesthetics. Neuromuscular blocking agents Biological and medical sciences Bipolar Disorder - therapy Depressive Disorder, Major - therapy Electroconvulsive Therapy Electroencephalography - drug effects Female Humans Ketamine - adverse effects Male Medical sciences Methohexital - administration & dosage Middle Aged Neuropharmacology Orientation - drug effects Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychotic Disorders - therapy Retrospective Studies Signal Processing, Computer-Assisted Treatments |
| title | Comparison of Seizure Duration, Ictal EEG, and Cognitive Effects of Ketamine and Methohexital Anesthesia With ECT |
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