Comparison of the Effectiveness of Geranylgeranylacetone with Cimetidine in Gastritis Patients with Dyspeptic Symptoms and Gastric Lesions: A Randomized, Double-Blind Trial in Japan
Background and Aim: Controversy remains regarding the treatment of choice for chronic gastritis patients with dyspeptic symptoms when Helicobacter pylori eradication is not indicated or fails for their gastric lesions. A multicenter, randomized, double-blind trial was performed to compare the effect...
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| Veröffentlicht in: | Digestion 2007-01, Vol.75 (4), p.215-224 |
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| creator | Sakamoto, Choitsu Ogoshi, Kazuei Saigenji, Katsunori Narisawa, Rintarou Nagura, Hiroshi Mine, Tetsuya Tada, Masahiro Umegaki, Eiji Maekawa, Takama Maekawa, Ryuichiro Maeda, Kazuhiro |
| description | Background and Aim: Controversy remains regarding the treatment of choice for chronic gastritis patients with dyspeptic symptoms when Helicobacter pylori eradication is not indicated or fails for their gastric lesions. A multicenter, randomized, double-blind trial was performed to compare the effectiveness of geranylgeranylacetone (GGA), a mucoprotective drug, against cimetidine (CIT), an H 2 -receptor antagonist, on the treatment of erosions and petechial hemorrhage in H. pylori-infected patients with dyspeptic symptoms. Methods: 128 H. pylori-positive gastritis patients with mucosal erosions and/or petechial hemorrhage were randomized to receive 150 mg GGA t.i.d. or 400 mg CIT b.i.d. for 2 weeks. Improvement and cure rates on endoscopic findings, symptom disappearance rates, and changes in mucosal neutrophil infiltration were compared. Results: Endoscopic improvement rates were significantly higher in the GGA group (n = 50) than in the CIT group (n = 54; 86.0 vs. 64.8%, p = 0.014). Endoscopic cure rates were also significantly higher for GGA than for CIT (80.0 vs. 55.6%, p = 0.012). Symptom disappearance rates were 52.0% for GGA and 42.6% for CIT, but the difference was not significant. There was also no significant difference in mucosal neutrophil infiltration between the groups. Conclusion: GGA treatment appears to be more effective than CIT for chronic gastritis-associated erosion and petechial hemorrhage. |
| doi_str_mv | 10.1159/000110654 |
| format | Article |
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A multicenter, randomized, double-blind trial was performed to compare the effectiveness of geranylgeranylacetone (GGA), a mucoprotective drug, against cimetidine (CIT), an H 2 -receptor antagonist, on the treatment of erosions and petechial hemorrhage in H. pylori-infected patients with dyspeptic symptoms. Methods: 128 H. pylori-positive gastritis patients with mucosal erosions and/or petechial hemorrhage were randomized to receive 150 mg GGA t.i.d. or 400 mg CIT b.i.d. for 2 weeks. Improvement and cure rates on endoscopic findings, symptom disappearance rates, and changes in mucosal neutrophil infiltration were compared. Results: Endoscopic improvement rates were significantly higher in the GGA group (n = 50) than in the CIT group (n = 54; 86.0 vs. 64.8%, p = 0.014). Endoscopic cure rates were also significantly higher for GGA than for CIT (80.0 vs. 55.6%, p = 0.012). Symptom disappearance rates were 52.0% for GGA and 42.6% for CIT, but the difference was not significant. There was also no significant difference in mucosal neutrophil infiltration between the groups. Conclusion: GGA treatment appears to be more effective than CIT for chronic gastritis-associated erosion and petechial hemorrhage.</description><identifier>ISSN: 0012-2823</identifier><identifier>EISSN: 1421-9867</identifier><identifier>DOI: 10.1159/000110654</identifier><identifier>PMID: 17971666</identifier><identifier>CODEN: DIGEBW</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Anti-Ulcer Agents - therapeutic use ; Cimetidine - therapeutic use ; Diterpenes - therapeutic use ; Double-Blind Method ; Dyspepsia - drug therapy ; Dyspepsia - microbiology ; Female ; Gastritis - drug therapy ; Gastritis - microbiology ; Gastroscopy ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Humans ; Japan ; Male ; Middle Aged ; Original Paper ; Statistics, Nonparametric ; Treatment Outcome</subject><ispartof>Digestion, 2007-01, Vol.75 (4), p.215-224</ispartof><rights>2007 S. Karger AG, Basel</rights><rights>(c) 2007 S. Karger AG, Basel</rights><rights>Copyright (c) 2007 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-8b427592c644a96dc01826524bf253bbdc8730486a6ebef9d789ee47cbf4f1723</citedby><cites>FETCH-LOGICAL-c362t-8b427592c644a96dc01826524bf253bbdc8730486a6ebef9d789ee47cbf4f1723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2422,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17971666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakamoto, Choitsu</creatorcontrib><creatorcontrib>Ogoshi, Kazuei</creatorcontrib><creatorcontrib>Saigenji, Katsunori</creatorcontrib><creatorcontrib>Narisawa, Rintarou</creatorcontrib><creatorcontrib>Nagura, Hiroshi</creatorcontrib><creatorcontrib>Mine, Tetsuya</creatorcontrib><creatorcontrib>Tada, Masahiro</creatorcontrib><creatorcontrib>Umegaki, Eiji</creatorcontrib><creatorcontrib>Maekawa, Takama</creatorcontrib><creatorcontrib>Maekawa, Ryuichiro</creatorcontrib><creatorcontrib>Maeda, Kazuhiro</creatorcontrib><title>Comparison of the Effectiveness of Geranylgeranylacetone with Cimetidine in Gastritis Patients with Dyspeptic Symptoms and Gastric Lesions: A Randomized, Double-Blind Trial in Japan</title><title>Digestion</title><addtitle>Digestion</addtitle><description>Background and Aim: Controversy remains regarding the treatment of choice for chronic gastritis patients with dyspeptic symptoms when Helicobacter pylori eradication is not indicated or fails for their gastric lesions. A multicenter, randomized, double-blind trial was performed to compare the effectiveness of geranylgeranylacetone (GGA), a mucoprotective drug, against cimetidine (CIT), an H 2 -receptor antagonist, on the treatment of erosions and petechial hemorrhage in H. pylori-infected patients with dyspeptic symptoms. Methods: 128 H. pylori-positive gastritis patients with mucosal erosions and/or petechial hemorrhage were randomized to receive 150 mg GGA t.i.d. or 400 mg CIT b.i.d. for 2 weeks. Improvement and cure rates on endoscopic findings, symptom disappearance rates, and changes in mucosal neutrophil infiltration were compared. Results: Endoscopic improvement rates were significantly higher in the GGA group (n = 50) than in the CIT group (n = 54; 86.0 vs. 64.8%, p = 0.014). Endoscopic cure rates were also significantly higher for GGA than for CIT (80.0 vs. 55.6%, p = 0.012). Symptom disappearance rates were 52.0% for GGA and 42.6% for CIT, but the difference was not significant. There was also no significant difference in mucosal neutrophil infiltration between the groups. Conclusion: GGA treatment appears to be more effective than CIT for chronic gastritis-associated erosion and petechial hemorrhage.</description><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Cimetidine - therapeutic use</subject><subject>Diterpenes - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Dyspepsia - drug therapy</subject><subject>Dyspepsia - microbiology</subject><subject>Female</subject><subject>Gastritis - drug therapy</subject><subject>Gastritis - microbiology</subject><subject>Gastroscopy</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Statistics, Nonparametric</subject><subject>Treatment Outcome</subject><issn>0012-2823</issn><issn>1421-9867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0U1v1DAQBmALgei2cOCOkMUBCYlA_BE77q1sywJaCQTlHDnOmLokdrCdouV_8f_IkhWVuHAazejxWKMXoUekfElIpV6VZUlIKSp-B60Ip6RQtZB30Woe04LWlB2h45Su963i7D46IlJJIoRYoV_rMIw6uhQ8DhbnK8AX1oLJ7gY8pLQfbiBqv-u_LkUbyMED_uHyFV67AbLr3Nw7jzc65eiyS_ijzg58Tos636URxuwM_rwbxhyGhLXvDtzgLSQXfDrFZ_jTPA-D-wndC3wepraH4nXvZnsZne73f7zXo_YP0D2r-wQPD_UEfXlzcbl-W2w_bN6tz7aFYYLmom45lZWiRnCulehMSWoqKspbSyvWtp2pJSt5LbSAFqzqZK0AuDSt5ZZIyk7Qs2XvGMP3CVJuBpcM9L32EKbUCFUyRrj8L6SEcsH-wKf_wOswRT8f0RBVESUVq2f0fEEmhpQi2GaMbtBx15Cy2Sfe_E18tk8OC6d2gO5WHiKeweMFfNNxjvAWLO9_A7TWsPs</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Sakamoto, Choitsu</creator><creator>Ogoshi, Kazuei</creator><creator>Saigenji, Katsunori</creator><creator>Narisawa, Rintarou</creator><creator>Nagura, Hiroshi</creator><creator>Mine, Tetsuya</creator><creator>Tada, Masahiro</creator><creator>Umegaki, Eiji</creator><creator>Maekawa, Takama</creator><creator>Maekawa, Ryuichiro</creator><creator>Maeda, Kazuhiro</creator><general>S. 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A multicenter, randomized, double-blind trial was performed to compare the effectiveness of geranylgeranylacetone (GGA), a mucoprotective drug, against cimetidine (CIT), an H 2 -receptor antagonist, on the treatment of erosions and petechial hemorrhage in H. pylori-infected patients with dyspeptic symptoms. Methods: 128 H. pylori-positive gastritis patients with mucosal erosions and/or petechial hemorrhage were randomized to receive 150 mg GGA t.i.d. or 400 mg CIT b.i.d. for 2 weeks. Improvement and cure rates on endoscopic findings, symptom disappearance rates, and changes in mucosal neutrophil infiltration were compared. Results: Endoscopic improvement rates were significantly higher in the GGA group (n = 50) than in the CIT group (n = 54; 86.0 vs. 64.8%, p = 0.014). Endoscopic cure rates were also significantly higher for GGA than for CIT (80.0 vs. 55.6%, p = 0.012). Symptom disappearance rates were 52.0% for GGA and 42.6% for CIT, but the difference was not significant. There was also no significant difference in mucosal neutrophil infiltration between the groups. Conclusion: GGA treatment appears to be more effective than CIT for chronic gastritis-associated erosion and petechial hemorrhage.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>17971666</pmid><doi>10.1159/000110654</doi><tpages>10</tpages></addata></record> |
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| subjects | Anti-Ulcer Agents - therapeutic use Cimetidine - therapeutic use Diterpenes - therapeutic use Double-Blind Method Dyspepsia - drug therapy Dyspepsia - microbiology Female Gastritis - drug therapy Gastritis - microbiology Gastroscopy Helicobacter Infections - drug therapy Helicobacter pylori Humans Japan Male Middle Aged Original Paper Statistics, Nonparametric Treatment Outcome |
| title | Comparison of the Effectiveness of Geranylgeranylacetone with Cimetidine in Gastritis Patients with Dyspeptic Symptoms and Gastric Lesions: A Randomized, Double-Blind Trial in Japan |
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