GW28-e0914 A Novel Mechanism Underlying Energy Metabolic Disorders in Failing Heart: Defective Branched Chain Amino Acid Catabolism-Induced Mitochondrial Metabolic Enzyme Hyper-Succinylation

Methods MI was induced by coronary artery ligation in a mouse model of defective BCAA catabolism (protein phosphatase-2Cm [PP2Cm] knockout [KO]) or in wild type (WT) mice. In KO heart, chronic BCAA accumulation obviously suppressed cardiac glucose and lipid metabolism through inhibition of mitochond...

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Veröffentlicht in:	Journal of the American College of Cardiology 2017-10, Vol.70 (16), p.C34-C34
Hauptverfasser:	Zhang, Fuyang, Chen, Xiyao, Ma, Xinliang, Pei, Jianming, Tao, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Cardiology Catabolism Chain branching Coronary artery Enzymes Heart failure Metabolic disorders Mitochondria Rodents
Online-Zugang:	Volltext
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