Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine

Purpose Vincristine is known to interfere with OATP-mediated uptake of other compounds, hinting that vincristine itself could be a substrate of OATP transporters. The present study therefore aimed to investigate the role of OATP transporters in the hepatocellular disposition of vincristine. Methods...

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Veröffentlicht in:	Pharmaceutical research 2017-11, Vol.34 (11), p.2336-2348
Hauptverfasser:	Nicolaï, Johan, Thevelin, Louise, Bing, Qi, Stieger, Bruno, Chanteux, Hugues, Augustijns, Patrick, Annaert, Pieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Benzbromarone - pharmacology Biochemistry Biological Transport Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine CHO Cells Cricetinae Cricetulus Hepatocytes Hepatocytes - metabolism Inhibitors Liver Liver - metabolism Male Material requirements planning MDR1 protein Medical Law Membrane vesicles Organic Anion Transporters - antagonists & inhibitors Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Pharmacology/Toxicology Pharmacy Protein Isoforms - antagonists & inhibitors Protein Isoforms - genetics Protein Isoforms - metabolism Rats, Wistar Research Paper Rodents Vesicles Vincristine Vincristine - metabolism Vincristine - pharmacology
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