Verocytotoxin-producingEscherichia coli infection in hemolytic uremic syndrome in part of Western Europe
From September 1989 until September 1993, stool specimens and sera from 113 children with diarrhoea-associated haemolytic uraemic syndrome (HUS) from the Netherlands, two university hospitals in Belgium and one university hospital in Germany were examined for the presence of verocytotoxin-producingE...
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| Veröffentlicht in: | European journal of pediatrics 1996-07, Vol.155 (7), p.592-595 |
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| creator | van de Kar, Nicole C. A. J. Roelofs, Hannie G. R. Muytjens, Harry L. Tolboom, Jules J. M. Roth, Bernhard Proesmans, Willem Reitsma-Bierens, Willy C. C. Wolff, Eric D. Karmali, Mohamed A. Chart, Herik Monnens, Leo A. H. |
| description | From September 1989 until September 1993, stool specimens and sera from 113 children with diarrhoea-associated haemolytic uraemic syndrome (HUS) from the Netherlands, two university hospitals in Belgium and one university hospital in Germany were examined for the presence of verocytotoxin-producingEscherichia coli (VTEC) infection. Evidence for VTEC infection was observed in 88 (78%) patients with HUS compared to 2 (3%) of the 65 children with acute gastro-enteritis Serotype O157 was the causative agent in 76 (86%) of these 88 patients with VTEC-associated HUS and verocytotoxin-2 (VT-2) was the most frequent toxin produced. Serological testing for antibodies to O157 O-antigen yielded the highest number of positive results compared to the other test methods. Antibodies to O157 were found in sera of 71 (65%) of 110 patients with HUS and one control serum. Stool and sera examination for VTEC in 95 family contacts of 28 patients with HUS demonstrated an evidence for VTEC infection 33 (35%). In contrast, in patients with HUS serological antibodies to O157 O-antigen were found in only 3 (4%) of 85 family contacts. |
| doi_str_mv | 10.1007/BF01957911 |
| format | Article |
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A. J. ; Roelofs, Hannie G. R. ; Muytjens, Harry L. ; Tolboom, Jules J. M. ; Roth, Bernhard ; Proesmans, Willem ; Reitsma-Bierens, Willy C. C. ; Wolff, Eric D. ; Karmali, Mohamed A. ; Chart, Herik ; Monnens, Leo A. H.</creator><creatorcontrib>van de Kar, Nicole C. A. J. ; Roelofs, Hannie G. R. ; Muytjens, Harry L. ; Tolboom, Jules J. M. ; Roth, Bernhard ; Proesmans, Willem ; Reitsma-Bierens, Willy C. C. ; Wolff, Eric D. ; Karmali, Mohamed A. ; Chart, Herik ; Monnens, Leo A. H.</creatorcontrib><description>From September 1989 until September 1993, stool specimens and sera from 113 children with diarrhoea-associated haemolytic uraemic syndrome (HUS) from the Netherlands, two university hospitals in Belgium and one university hospital in Germany were examined for the presence of verocytotoxin-producingEscherichia coli (VTEC) infection. Evidence for VTEC infection was observed in 88 (78%) patients with HUS compared to 2 (3%) of the 65 children with acute gastro-enteritis Serotype O157 was the causative agent in 76 (86%) of these 88 patients with VTEC-associated HUS and verocytotoxin-2 (VT-2) was the most frequent toxin produced. Serological testing for antibodies to O157 O-antigen yielded the highest number of positive results compared to the other test methods. Antibodies to O157 were found in sera of 71 (65%) of 110 patients with HUS and one control serum. Stool and sera examination for VTEC in 95 family contacts of 28 patients with HUS demonstrated an evidence for VTEC infection 33 (35%). In contrast, in patients with HUS serological antibodies to O157 O-antigen were found in only 3 (4%) of 85 family contacts.</description><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/BF01957911</identifier><language>eng</language><publisher>Berlin: Springer Nature B.V</publisher><subject>Antibodies ; Antigens ; Children ; Diarrhea ; Enteritis ; Hemolytic uremic syndrome ; Immunoglobulins ; Infections ; Verocytotoxin</subject><ispartof>European journal of pediatrics, 1996-07, Vol.155 (7), p.592-595</ispartof><rights>Springer-Verlag 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c630-e2533ffee8af9b431499234316955595bd8aebc4f3f56dad37530d0c04169ea83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>van de Kar, Nicole C. 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H.</creatorcontrib><title>Verocytotoxin-producingEscherichia coli infection in hemolytic uremic syndrome in part of Western Europe</title><title>European journal of pediatrics</title><description>From September 1989 until September 1993, stool specimens and sera from 113 children with diarrhoea-associated haemolytic uraemic syndrome (HUS) from the Netherlands, two university hospitals in Belgium and one university hospital in Germany were examined for the presence of verocytotoxin-producingEscherichia coli (VTEC) infection. Evidence for VTEC infection was observed in 88 (78%) patients with HUS compared to 2 (3%) of the 65 children with acute gastro-enteritis Serotype O157 was the causative agent in 76 (86%) of these 88 patients with VTEC-associated HUS and verocytotoxin-2 (VT-2) was the most frequent toxin produced. Serological testing for antibodies to O157 O-antigen yielded the highest number of positive results compared to the other test methods. Antibodies to O157 were found in sera of 71 (65%) of 110 patients with HUS and one control serum. Stool and sera examination for VTEC in 95 family contacts of 28 patients with HUS demonstrated an evidence for VTEC infection 33 (35%). In contrast, in patients with HUS serological antibodies to O157 O-antigen were found in only 3 (4%) of 85 family contacts.</description><subject>Antibodies</subject><subject>Antigens</subject><subject>Children</subject><subject>Diarrhea</subject><subject>Enteritis</subject><subject>Hemolytic uremic syndrome</subject><subject>Immunoglobulins</subject><subject>Infections</subject><subject>Verocytotoxin</subject><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpFkF1LwzAUhoMoOKc3_oKAd0L1ZGna5lLHpsLAm6GXJUtPbMaa1KQF--_NmODVe-A8nI-HkFsGDwygfHxeA5OilIydkRnL-SJjUBbnZAY8h6xgUl6Sqxj3kGDJqhlpPzB4PQ1-8D_WZX3wzait-1pF3WKwurWKan-w1DqDerDepYq22PnDNFhNx4Bdiji5JvgOj81ehYF6Qz8xDhgcXY3B93hNLow6RLz5yznZrlfb5Wu2eX95Wz5tMl1wyHAhODcGsVJG7nLOcikXPGUhhRBS7JpK4U7nhhtRNKrhpeDQgIY8EagqPid3p7Hpk-8xXVDv_Rhc2lgnMSzZyCUk6v5E6eBjDGjqPthOhalmUB9F1v8i-S8TqGac</recordid><startdate>199607</startdate><enddate>199607</enddate><creator>van de Kar, Nicole C. 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A. J.</au><au>Roelofs, Hannie G. R.</au><au>Muytjens, Harry L.</au><au>Tolboom, Jules J. M.</au><au>Roth, Bernhard</au><au>Proesmans, Willem</au><au>Reitsma-Bierens, Willy C. C.</au><au>Wolff, Eric D.</au><au>Karmali, Mohamed A.</au><au>Chart, Herik</au><au>Monnens, Leo A. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Verocytotoxin-producingEscherichia coli infection in hemolytic uremic syndrome in part of Western Europe</atitle><jtitle>European journal of pediatrics</jtitle><date>1996-07</date><risdate>1996</risdate><volume>155</volume><issue>7</issue><spage>592</spage><epage>595</epage><pages>592-595</pages><issn>0340-6199</issn><eissn>1432-1076</eissn><abstract>From September 1989 until September 1993, stool specimens and sera from 113 children with diarrhoea-associated haemolytic uraemic syndrome (HUS) from the Netherlands, two university hospitals in Belgium and one university hospital in Germany were examined for the presence of verocytotoxin-producingEscherichia coli (VTEC) infection. 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| subjects | Antibodies Antigens Children Diarrhea Enteritis Hemolytic uremic syndrome Immunoglobulins Infections Verocytotoxin |
| title | Verocytotoxin-producingEscherichia coli infection in hemolytic uremic syndrome in part of Western Europe |
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