Effect of cytokines (IL-2, IL-7, and IL-15) having common γ-chain of receptors on differentiation and maturation of CD4+/CD8+ T-cells in a CD45RA T-lymphocyte population in vitro
The effect of cytokines (IL-2, IL-7, and IL-15) having a common γ-chain of receptors on the maturation and differentiation of CD3 + CD45RA + CD4 + /CD8 + lymphocytes in homeostatic cultivation model in vitro was analyzed. It was found that the maximum IL-2 concentration in the helper CD45RA + -T-cel...
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| Veröffentlicht in: | Cell and tissue biology 2017-09, Vol.11 (5), p.356-362 |
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| container_title | Cell and tissue biology |
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| creator | Yurova, K. A. Khaziakhmatova, O. G. Dunets, N. A. Todosenko, N. M. Shupletsova, V. V. Litvinova, L. S. |
| description | The effect of cytokines (IL-2, IL-7, and IL-15) having a common γ-chain of receptors on the maturation and differentiation of CD3
+
CD45RA
+
CD4
+
/CD8
+
lymphocytes in homeostatic cultivation model in vitro was analyzed. It was found that the maximum IL-2 concentration in the helper CD45RA
+
-T-cell population mediates an increase in the number of CD45RA
+
CD4
+
T lymphocytes with the phenotype of mature and immature terminally differentiated TEMRA T cells. IL-15 leads to the production of lymphocytes with CD27
–
CD62L
+
phenotype (presumably, TEMRA, in which the CD62L expression persists). In the CD45RA
+
CD8
+
T lymphocyte populations, the studied cytokines (IL-2, IL-7, and IL-15) initiate the production of mature TEMRA (E) T lymphocytes and memory T cells with the CD45RA
−
CD27
+
CD62L
+
central phenotype (TCM). |
| doi_str_mv | 10.1134/S1990519X1705011X |
| format | Article |
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+
CD45RA
+
CD4
+
/CD8
+
lymphocytes in homeostatic cultivation model in vitro was analyzed. It was found that the maximum IL-2 concentration in the helper CD45RA
+
-T-cell population mediates an increase in the number of CD45RA
+
CD4
+
T lymphocytes with the phenotype of mature and immature terminally differentiated TEMRA T cells. IL-15 leads to the production of lymphocytes with CD27
–
CD62L
+
phenotype (presumably, TEMRA, in which the CD62L expression persists). In the CD45RA
+
CD8
+
T lymphocyte populations, the studied cytokines (IL-2, IL-7, and IL-15) initiate the production of mature TEMRA (E) T lymphocytes and memory T cells with the CD45RA
−
CD27
+
CD62L
+
central phenotype (TCM).</description><identifier>ISSN: 1990-519X</identifier><identifier>EISSN: 1990-5203</identifier><identifier>DOI: 10.1134/S1990519X1705011X</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Biomedical and Life Sciences ; CD27 antigen ; CD3 antigen ; CD4 antigen ; CD45RA antigen ; CD8 antigen ; Cell Biology ; Cytokines ; Genotype & phenotype ; Immunological memory ; Interleukin 15 ; Interleukin 2 ; Interleukin 7 ; L-selectin ; Life Sciences ; Lymphocytes ; Lymphocytes T ; Memory cells ; Population studies</subject><ispartof>Cell and tissue biology, 2017-09, Vol.11 (5), p.356-362</ispartof><rights>Pleiades Publishing, Ltd. 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c231X-6bae35d7f16ae6a4f79a6ac2933e9c64b9df1f641fb211aee5fb040a64ef12c23</citedby><cites>FETCH-LOGICAL-c231X-6bae35d7f16ae6a4f79a6ac2933e9c64b9df1f641fb211aee5fb040a64ef12c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1990519X1705011X$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1990519X1705011X$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Yurova, K. A.</creatorcontrib><creatorcontrib>Khaziakhmatova, O. G.</creatorcontrib><creatorcontrib>Dunets, N. A.</creatorcontrib><creatorcontrib>Todosenko, N. M.</creatorcontrib><creatorcontrib>Shupletsova, V. V.</creatorcontrib><creatorcontrib>Litvinova, L. S.</creatorcontrib><title>Effect of cytokines (IL-2, IL-7, and IL-15) having common γ-chain of receptors on differentiation and maturation of CD4+/CD8+ T-cells in a CD45RA T-lymphocyte population in vitro</title><title>Cell and tissue biology</title><addtitle>Cell Tiss. Biol</addtitle><description>The effect of cytokines (IL-2, IL-7, and IL-15) having a common γ-chain of receptors on the maturation and differentiation of CD3
+
CD45RA
+
CD4
+
/CD8
+
lymphocytes in homeostatic cultivation model in vitro was analyzed. It was found that the maximum IL-2 concentration in the helper CD45RA
+
-T-cell population mediates an increase in the number of CD45RA
+
CD4
+
T lymphocytes with the phenotype of mature and immature terminally differentiated TEMRA T cells. IL-15 leads to the production of lymphocytes with CD27
–
CD62L
+
phenotype (presumably, TEMRA, in which the CD62L expression persists). In the CD45RA
+
CD8
+
T lymphocyte populations, the studied cytokines (IL-2, IL-7, and IL-15) initiate the production of mature TEMRA (E) T lymphocytes and memory T cells with the CD45RA
−
CD27
+
CD62L
+
central phenotype (TCM).</description><subject>Biomedical and Life Sciences</subject><subject>CD27 antigen</subject><subject>CD3 antigen</subject><subject>CD4 antigen</subject><subject>CD45RA antigen</subject><subject>CD8 antigen</subject><subject>Cell Biology</subject><subject>Cytokines</subject><subject>Genotype & phenotype</subject><subject>Immunological memory</subject><subject>Interleukin 15</subject><subject>Interleukin 2</subject><subject>Interleukin 7</subject><subject>L-selectin</subject><subject>Life Sciences</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Memory cells</subject><subject>Population studies</subject><issn>1990-519X</issn><issn>1990-5203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kdFKwzAUhosoOKcP4F3AG2Wry2nTbL0c29TBQNAJuytZdrJ1tk1NusGea-_hM5lSBUG8Sc75z_9_CRzPuwZ6DxCy3ivEMY0gXkCfRhRgceK1asmPAhqe_tRufu5dWLullFMGtOUdJ0qhrIhWRB4q_Z4WaMntdOYHXeLOfpeIYlVXEN2RjdinxZpInee6IJ9HX25EWtRZgxLLShtL3GCVOqbBokpFlbq-JuSi2pmmdfbRmHV6o_GgQ-a-xCyzxGFELUcvQ6dlh7zcaPchJKUud1kTdJ59Whl96Z0pkVm8-r7b3tvDZD568mfPj9PRcObLIISFz5cCw2jVV8AFcsFUPxZcyCAOQ4wlZ8t4pUBxBmoZAAjESC0po4IzVBA4Rtu7abil0R87tFWy1TtTuCcTiCPKOAwYdS5oXNJoaw2qpDRpLswhAZrUu0n-7MZlgiZjnbdYo_lF_jf0BetzkHA</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Yurova, K. A.</creator><creator>Khaziakhmatova, O. G.</creator><creator>Dunets, N. A.</creator><creator>Todosenko, N. M.</creator><creator>Shupletsova, V. V.</creator><creator>Litvinova, L. S.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20170901</creationdate><title>Effect of cytokines (IL-2, IL-7, and IL-15) having common γ-chain of receptors on differentiation and maturation of CD4+/CD8+ T-cells in a CD45RA T-lymphocyte population in vitro</title><author>Yurova, K. A. ; Khaziakhmatova, O. G. ; Dunets, N. A. ; Todosenko, N. M. ; Shupletsova, V. V. ; Litvinova, L. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c231X-6bae35d7f16ae6a4f79a6ac2933e9c64b9df1f641fb211aee5fb040a64ef12c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biomedical and Life Sciences</topic><topic>CD27 antigen</topic><topic>CD3 antigen</topic><topic>CD4 antigen</topic><topic>CD45RA antigen</topic><topic>CD8 antigen</topic><topic>Cell Biology</topic><topic>Cytokines</topic><topic>Genotype & phenotype</topic><topic>Immunological memory</topic><topic>Interleukin 15</topic><topic>Interleukin 2</topic><topic>Interleukin 7</topic><topic>L-selectin</topic><topic>Life Sciences</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Memory cells</topic><topic>Population studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yurova, K. A.</creatorcontrib><creatorcontrib>Khaziakhmatova, O. G.</creatorcontrib><creatorcontrib>Dunets, N. A.</creatorcontrib><creatorcontrib>Todosenko, N. M.</creatorcontrib><creatorcontrib>Shupletsova, V. V.</creatorcontrib><creatorcontrib>Litvinova, L. S.</creatorcontrib><collection>CrossRef</collection><jtitle>Cell and tissue biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yurova, K. A.</au><au>Khaziakhmatova, O. G.</au><au>Dunets, N. A.</au><au>Todosenko, N. M.</au><au>Shupletsova, V. V.</au><au>Litvinova, L. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of cytokines (IL-2, IL-7, and IL-15) having common γ-chain of receptors on differentiation and maturation of CD4+/CD8+ T-cells in a CD45RA T-lymphocyte population in vitro</atitle><jtitle>Cell and tissue biology</jtitle><stitle>Cell Tiss. Biol</stitle><date>2017-09-01</date><risdate>2017</risdate><volume>11</volume><issue>5</issue><spage>356</spage><epage>362</epage><pages>356-362</pages><issn>1990-519X</issn><eissn>1990-5203</eissn><abstract>The effect of cytokines (IL-2, IL-7, and IL-15) having a common γ-chain of receptors on the maturation and differentiation of CD3
+
CD45RA
+
CD4
+
/CD8
+
lymphocytes in homeostatic cultivation model in vitro was analyzed. It was found that the maximum IL-2 concentration in the helper CD45RA
+
-T-cell population mediates an increase in the number of CD45RA
+
CD4
+
T lymphocytes with the phenotype of mature and immature terminally differentiated TEMRA T cells. IL-15 leads to the production of lymphocytes with CD27
–
CD62L
+
phenotype (presumably, TEMRA, in which the CD62L expression persists). In the CD45RA
+
CD8
+
T lymphocyte populations, the studied cytokines (IL-2, IL-7, and IL-15) initiate the production of mature TEMRA (E) T lymphocytes and memory T cells with the CD45RA
−
CD27
+
CD62L
+
central phenotype (TCM).</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1990519X1705011X</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1990-519X |
| ispartof | Cell and tissue biology, 2017-09, Vol.11 (5), p.356-362 |
| issn | 1990-519X 1990-5203 |
| language | eng |
| recordid | cdi_proquest_journals_1950461840 |
| source | SpringerLink Journals |
| subjects | Biomedical and Life Sciences CD27 antigen CD3 antigen CD4 antigen CD45RA antigen CD8 antigen Cell Biology Cytokines Genotype & phenotype Immunological memory Interleukin 15 Interleukin 2 Interleukin 7 L-selectin Life Sciences Lymphocytes Lymphocytes T Memory cells Population studies |
| title | Effect of cytokines (IL-2, IL-7, and IL-15) having common γ-chain of receptors on differentiation and maturation of CD4+/CD8+ T-cells in a CD45RA T-lymphocyte population in vitro |
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