Therapeutic Effects of FGF23 c‐tail Fc in a Murine Preclinical Model of X‐Linked Hypophosphatemia Via the Selective Modulation of Phosphate Reabsorption

ABSTRACT Fibroblast growth factor 23 (FGF23) is the causative factor of X‐linked hypophosphatemia (XLH), a genetic disorder effecting 1:20,000 that is characterized by excessive phosphate excretion, elevated FGF23 levels and a rickets/osteomalacia phenotype. FGF23 inhibits phosphate reabsorption and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of bone and mineral research 2017-10, Vol.32 (10), p.2062-2073
Hauptverfasser:	Johnson, Kristen, Levine, Kymberly, Sergi, Joseph, Chamoun, Jean, Roach, Rachel, Vekich, Jacqueline, Favis, Mike, Horn, Mark, Cao, Xianjun, Miller, Brian, Snyder, William, Aivazian, Dikran, Reagan, William, Berryman, Edwin, Colangelo, Jennifer, Markiewicz, Victoria, Bagi, Cedo M, Brown, Thomas P, Coyle, Anthony, Mohammadi, Moosa, Magram, Jeanne
Format:	Artikel
Sprache:	eng
Schlagworte:	1,25D Animal models Animals Bone and Bones - diagnostic imaging Bone and Bones - drug effects Bone and Bones - pathology Bone Density - drug effects Calcification, Physiologic - drug effects Calcitriol - blood Calcitriol - pharmacology Calcium Calcium - blood Cancellous Bone - pathology Cell surface Disease Models, Animal Excretion Familial Hypophosphatemic Rickets - blood Familial Hypophosphatemic Rickets - diagnostic imaging Familial Hypophosphatemic Rickets - drug therapy FIBROBLAST GROWTH FACTOR 23 Fibroblast growth factor receptors Fibroblast Growth Factors - chemistry Fibroblast Growth Factors - therapeutic use Genetic disorders HEK293 Cells Humans Hypophosphatemia Injection Klotho protein Mice Mineralization OSTEOMALACIA Peptides - pharmacology PHOSPHATE Phosphates - blood Rats, Wistar Reabsorption Recombinant Proteins - pharmacology Renal Reabsorption - drug effects Rickets Toxicity Vitamin D X‐LINKED HYPOPHOSPHATEMIA
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!