Molecular, cellular and pharmacological effects of platinum(II) diiodido complexes containing 9-deazahypoxanthine derivatives: A group of broad-spectrum anticancer active agents

The platinum(II) iodido complexes 1–5 of the general formula cis-[PtI2(Ln)2], where Ln stands for O-substituted 9-deazahypoxanthine derivatives, were prepared and thoroughly characterized by various techniques, including multinuclear 1D and 2D NMR spectroscopy. The complexes were screened for their...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2017-08, Vol.173, p.423-433
Hauptverfasser:	Vančo, Ján, Trávníček, Zdeněk, Křikavová, Radka, Gáliková, Jana, Dvořák, Zdeněk, Chalupová, Marta
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Alkoxy-9-deazapurines Adenocarcinoma Animals Anticancer Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Antitumor activity Apoptosis - drug effects Biocompatibility Biomedical materials Biotechnology Breast cancer Cancer Cell cycle Cell Line, Tumor Cervix Cisplatin Coordination Complexes - chemistry Coordination Complexes - therapeutic use Coordination Complexes - toxicity Derivatives Drug Screening Assays, Antitumor Effects Female Glutathione Guanosine HeLa Cells Hep G2 Cells Hepatocellular carcinoma Humans Hypoxanthines - chemistry In vitro In vivo In vivo methods and tests Intermediates Iodido complexes Iodine - chemistry Ionization Kaplan-Meier Estimate Leukemia Lipophilic Lipophilicity Lung carcinoma Magnetic resonance spectroscopy Mass spectrometry Mass spectroscopy MCF-7 Cells Melanoma Mice Mice, Inbred DBA Neoplasms - drug therapy Neoplasms - mortality Neoplasms - pathology NMR spectroscopy Osteosarcoma Ovarian cancer Ovarian carcinoma Pharmacology Platinum Platinum - chemistry Platinum(II) complexes Prolongation Prostate Prostate carcinoma Structure-activity relationships Studies Sulfur Surgical implants Transplantation, Heterologous Tumor cell lines
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