Pentanoic acid induces thymic stromal lymphopoietin production through G^sub q/11^ and Rho-associated protein kinase signaling pathway in keratinocytes
Thymic stromal lymphopoietin (TSLP) plays an important role in allergic skin inflammation. Short-chain fatty acids (SCFAs), including pentanoic acid, are products of bacterial metabolism and are associated with allergic skin disorders. However, whether SCFAs induce TSLP production is still unclear....
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| Veröffentlicht in: | International immunopharmacology 2017-09, Vol.50, p.216 |
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| creator | Mizuno, Natsumi Abe, Koudai Morishita, Yukari Yamashita, Saori Segawa, Ryosuke Dong, Jiangxu Moriya, Takahiro Hiratsuka, Masahiro Hirasawa, Noriyasu |
| description | Thymic stromal lymphopoietin (TSLP) plays an important role in allergic skin inflammation. Short-chain fatty acids (SCFAs), including pentanoic acid, are products of bacterial metabolism and are associated with allergic skin disorders. However, whether SCFAs induce TSLP production is still unclear. In this study, we evaluated the effect of SCFAs on TSLP production and found that pentanoic acid was the most efficacious of the tested SCFAs. The Gq/11 inhibitor YM-254890 and the Rho-associated protein kinase (ROCK) inhibitor Y-27632 inhibited pentanoic acid-induced TSLP production, as did transfection with Gq/11 siRNA. These results suggested that pentanoic acid-induced TSLP production was mediated by Gq/11 and ROCK, providing insights into a novel TSLP production pathway in keratinocytes. The novel mechanism of TSLP production is expected to support the development of TSLP-regulating approaches in allergic skin disorders. |
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Short-chain fatty acids (SCFAs), including pentanoic acid, are products of bacterial metabolism and are associated with allergic skin disorders. However, whether SCFAs induce TSLP production is still unclear. In this study, we evaluated the effect of SCFAs on TSLP production and found that pentanoic acid was the most efficacious of the tested SCFAs. The Gq/11 inhibitor YM-254890 and the Rho-associated protein kinase (ROCK) inhibitor Y-27632 inhibited pentanoic acid-induced TSLP production, as did transfection with Gq/11 siRNA. These results suggested that pentanoic acid-induced TSLP production was mediated by Gq/11 and ROCK, providing insights into a novel TSLP production pathway in keratinocytes. 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Short-chain fatty acids (SCFAs), including pentanoic acid, are products of bacterial metabolism and are associated with allergic skin disorders. However, whether SCFAs induce TSLP production is still unclear. In this study, we evaluated the effect of SCFAs on TSLP production and found that pentanoic acid was the most efficacious of the tested SCFAs. The Gq/11 inhibitor YM-254890 and the Rho-associated protein kinase (ROCK) inhibitor Y-27632 inhibited pentanoic acid-induced TSLP production, as did transfection with Gq/11 siRNA. These results suggested that pentanoic acid-induced TSLP production was mediated by Gq/11 and ROCK, providing insights into a novel TSLP production pathway in keratinocytes. The novel mechanism of TSLP production is expected to support the development of TSLP-regulating approaches in allergic skin disorders.</description><subject>Bacteria</subject><subject>Disorders</subject><subject>Enzyme inhibitors</subject><subject>Fatty acids</subject><subject>Inhibitors</subject><subject>Keratinocytes</subject><subject>Kinases</subject><subject>Metabolism</subject><subject>Protein kinase</subject><subject>Proteins</subject><subject>Signal transduction</subject><subject>siRNA</subject><subject>Skin diseases</subject><subject>Thymic stromal lymphopoietin</subject><subject>Thymus</subject><subject>Transfection</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNjMtOwzAQRSMEEoXyDyOxjrAV8uga8VgixLrV1HHjKYkn9dhC-RJ-F1fiA1jN6N5zz0Wx0l3blbpV9WX-66Yt67bZXBc3Ikelcv6oV8XPu_URPZMBNNQD-T4ZKxDdMuVMYuAJRxiXaXY8M9lIHubAmYrEPnOB0-DgdStpD6cHrbeAvocPxyWKsCGMtj8vos3LL_IoFoQGjyP5AWaM7hsXOHc2YLazWaKVdXF1wFHs3d-9Le5fnj-f3spsOiUrcXfkFLJEdnpTK9U0VVdV_6N-AbJKW-4</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Mizuno, Natsumi</creator><creator>Abe, Koudai</creator><creator>Morishita, Yukari</creator><creator>Yamashita, Saori</creator><creator>Segawa, Ryosuke</creator><creator>Dong, Jiangxu</creator><creator>Moriya, Takahiro</creator><creator>Hiratsuka, Masahiro</creator><creator>Hirasawa, Noriyasu</creator><general>Elsevier BV</general><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20170901</creationdate><title>Pentanoic acid induces thymic stromal lymphopoietin production through G^sub q/11^ and Rho-associated protein kinase signaling pathway in keratinocytes</title><author>Mizuno, Natsumi ; Abe, Koudai ; Morishita, Yukari ; Yamashita, Saori ; Segawa, Ryosuke ; Dong, Jiangxu ; Moriya, Takahiro ; Hiratsuka, Masahiro ; Hirasawa, Noriyasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_19500663833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Bacteria</topic><topic>Disorders</topic><topic>Enzyme inhibitors</topic><topic>Fatty acids</topic><topic>Inhibitors</topic><topic>Keratinocytes</topic><topic>Kinases</topic><topic>Metabolism</topic><topic>Protein kinase</topic><topic>Proteins</topic><topic>Signal transduction</topic><topic>siRNA</topic><topic>Skin diseases</topic><topic>Thymic stromal lymphopoietin</topic><topic>Thymus</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mizuno, Natsumi</creatorcontrib><creatorcontrib>Abe, Koudai</creatorcontrib><creatorcontrib>Morishita, Yukari</creatorcontrib><creatorcontrib>Yamashita, Saori</creatorcontrib><creatorcontrib>Segawa, Ryosuke</creatorcontrib><creatorcontrib>Dong, Jiangxu</creatorcontrib><creatorcontrib>Moriya, Takahiro</creatorcontrib><creatorcontrib>Hiratsuka, Masahiro</creatorcontrib><creatorcontrib>Hirasawa, Noriyasu</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mizuno, Natsumi</au><au>Abe, Koudai</au><au>Morishita, Yukari</au><au>Yamashita, Saori</au><au>Segawa, Ryosuke</au><au>Dong, Jiangxu</au><au>Moriya, Takahiro</au><au>Hiratsuka, Masahiro</au><au>Hirasawa, Noriyasu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pentanoic acid induces thymic stromal lymphopoietin production through G^sub q/11^ and Rho-associated protein kinase signaling pathway in keratinocytes</atitle><jtitle>International immunopharmacology</jtitle><date>2017-09-01</date><risdate>2017</risdate><volume>50</volume><spage>216</spage><pages>216-</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Thymic stromal lymphopoietin (TSLP) plays an important role in allergic skin inflammation. Short-chain fatty acids (SCFAs), including pentanoic acid, are products of bacterial metabolism and are associated with allergic skin disorders. However, whether SCFAs induce TSLP production is still unclear. In this study, we evaluated the effect of SCFAs on TSLP production and found that pentanoic acid was the most efficacious of the tested SCFAs. The Gq/11 inhibitor YM-254890 and the Rho-associated protein kinase (ROCK) inhibitor Y-27632 inhibited pentanoic acid-induced TSLP production, as did transfection with Gq/11 siRNA. These results suggested that pentanoic acid-induced TSLP production was mediated by Gq/11 and ROCK, providing insights into a novel TSLP production pathway in keratinocytes. The novel mechanism of TSLP production is expected to support the development of TSLP-regulating approaches in allergic skin disorders.</abstract><cop>Amsterdam</cop><pub>Elsevier BV</pub></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Bacteria Disorders Enzyme inhibitors Fatty acids Inhibitors Keratinocytes Kinases Metabolism Protein kinase Proteins Signal transduction siRNA Skin diseases Thymic stromal lymphopoietin Thymus Transfection |
| title | Pentanoic acid induces thymic stromal lymphopoietin production through G^sub q/11^ and Rho-associated protein kinase signaling pathway in keratinocytes |
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