Pharmacokinetic Studies with a Dual-Release Formulation of Levodopa, a Novel Principle in the Treatment of Parkinson’s Disease

The objectives of the two studies reported here were the investigation of the influence of tablet breaking and food on the pharmacokinetics of levodopa and 3-O-methyldopa (3-OMD) after administration of a new levodopa/benserazide formulation with a biphasic drug delivery profile (Madopar ® DR). Both...

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Veröffentlicht in:	European neurology 1998-01, Vol.39 (2), p.119-124
Hauptverfasser:	Dingemanse, J., Kleinbloesem, C.H., Crevoisier, Ch, Lankhaar, G., Gasser, U.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anticonvulsants. Antiepileptics. Antiparkinson agents Antiparkinson Agents - adverse effects Antiparkinson Agents - pharmacokinetics Antiparkinson Agents - therapeutic use Biological and medical sciences Cross-Over Studies Delayed-Action Preparations Female Food Humans Levodopa - adverse effects Levodopa - pharmacokinetics Levodopa - therapeutic use Male Medical sciences Neuropharmacology Original Paper Parkinson Disease - drug therapy Parkinson Disease - metabolism Pharmacology. Drug treatments Tablets Tyrosine - analogs & derivatives Tyrosine - pharmacokinetics
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