Mechanistic approach in powder blending PAT: Bi-layer mixing and asymptotic end point prediction

We derive a simple first order kinetics model for the powder mixing in a bin blender and adapt it to fit the NIR spectra obtained during the real-time mixing. The model is tested on a full drug product formulation mixing consisting of API and multiple excipients. It allows to extract a quantitative...

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Veröffentlicht in:	Powder technology 2017-02, Vol.308, p.306-317
Hauptverfasser:	Sibik, Juraj, Chalus, Pascal, Maurer, Lene, Murthy, Avinash, Krimmer, Siegfried
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Blend uniformity Convection Drug development Drugs Kinetics NIR Powder Powder blending Powder mixing Process analytical technology Process control Quality by design
Online-Zugang:	Volltext
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