Pharmacokinetics of vincristine in children and adolescents with acute lymphocytic leukemia

We studied the pharmacokinetics of vincristine in children with acute lymphocytic leukemia by means of a specific high-performance liquid chromatographic assay with ultraviolet and electrochemical detection and a limited sampling strategy. Our objectives were to characterize the disposition of vincr...

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Veröffentlicht in:	The Journal of pediatrics 1994-10, Vol.125 (4), p.642-649
Hauptverfasser:	Crom, William R., de Graaf, Siebold S.N., Synold, Timothy, Uges, Donald R.A., Bloemhof, Henk, Rivera, Gaston, Christensen, Michael L., Mahmoud, Hazem, Evans, William E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic agents Biological and medical sciences Chemotherapy Child Child, Preschool Female Humans Infant Male Medical sciences Metabolic Clearance Rate Nervous System - drug effects Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Vincristine - pharmacokinetics Vincristine - toxicity
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