Effects of Inclusion of Chrysin in Cucurbit[8]uril on Its Stability, Solubility and Antioxidant Potential
The host-guest interaction between cucurbit[8]uril（Q[8]） and chrysin（CHR） has been studied by means of 1H NMR, mass spectrometry（MS）, differential thermal analysis（DTA）, and UV-Vis spectrophotometry. The results show that CHR forms a 1：1 inclusion complex with Q[8], with a binding constant of CHR wi...
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| Veröffentlicht in: | Chemical research in Chinese universities 2017-10, Vol.33 (5), p.736-741 |
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| creator | Xu, Zhiling Lian, Xiaowei Li, Mengjie Zhang, Xiaodong Wang, Yi Tao, Zhu Zhang, Qianjun |
| description | The host-guest interaction between cucurbit[8]uril（Q[8]） and chrysin（CHR） has been studied by means of 1H NMR, mass spectrometry（MS）, differential thermal analysis（DTA）, and UV-Vis spectrophotometry. The results show that CHR forms a 1：1 inclusion complex with Q[8], with a binding constant of CHR with Q[8] by UV absorp- tion being 5.4 × 106. Phase solubility experiments show a 5.13-fold increase in the solubility of CHR through interac- tion with Q[8] {c（Q[8]）=10-4 real/L}. A study of the evolution of UV absorption spectra with time shows that Q[8] significantly increases the stability of CHR. The antioxidant activity of CHR-Q[8] has been tested by the ABTS me- thod. The CHR-Q[8] inclusion complex shows a better scavenging effect towards the ABTS radical than CHR, with respective IC50 values of 1.05 ×10-6 and 3.07× 10-6 mol/L. In vitro release studies have shown that CHR-Q[8] has a sustained release effcct. |
| doi_str_mv | 10.1007/s40242-017-7096-8 |
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The results show that CHR forms a 1：1 inclusion complex with Q[8], with a binding constant of CHR with Q[8] by UV absorp- tion being 5.4 × 106. Phase solubility experiments show a 5.13-fold increase in the solubility of CHR through interac- tion with Q[8] {c（Q[8]）=10-4 real/L}. A study of the evolution of UV absorption spectra with time shows that Q[8] significantly increases the stability of CHR. The antioxidant activity of CHR-Q[8] has been tested by the ABTS me- thod. The CHR-Q[8] inclusion complex shows a better scavenging effect towards the ABTS radical than CHR, with respective IC50 values of 1.05 ×10-6 and 3.07× 10-6 mol/L. In vitro release studies have shown that CHR-Q[8] has a sustained release effcct.</description><identifier>ISSN: 1005-9040</identifier><identifier>EISSN: 2210-3171</identifier><identifier>DOI: 10.1007/s40242-017-7096-8</identifier><language>eng</language><publisher>Changchun: Jilin University and The Editorial Department of Chemical Research in Chinese Universities</publisher><subject>Absorption spectra ; Analytical Chemistry ; Antioxidants ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Inorganic Chemistry ; Mass spectrometry ; NMR ; Nuclear magnetic resonance ; Organic Chemistry ; Physical Chemistry ; Solubility ; Spectrophotometry ; Stability ; Sustained release ; Thermal analysis ; 主客体相互作用 ; 包合作用 ; 抗氧化能力 ; 溶解性 ; 白杨素 ; 稳定性 ; 紫外-可见分光光度法 ; 葫芦</subject><ispartof>Chemical research in Chinese universities, 2017-10, Vol.33 (5), p.736-741</ispartof><rights>Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-403fec3e67e56e0559dc4a25cd0282674c46faa40a44ae972f90ed077ddd0fd93</citedby><cites>FETCH-LOGICAL-c343t-403fec3e67e56e0559dc4a25cd0282674c46faa40a44ae972f90ed077ddd0fd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/86071X/86071X.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40242-017-7096-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40242-017-7096-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Xu, Zhiling</creatorcontrib><creatorcontrib>Lian, Xiaowei</creatorcontrib><creatorcontrib>Li, Mengjie</creatorcontrib><creatorcontrib>Zhang, Xiaodong</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Tao, Zhu</creatorcontrib><creatorcontrib>Zhang, Qianjun</creatorcontrib><title>Effects of Inclusion of Chrysin in Cucurbit[8]uril on Its Stability, Solubility and Antioxidant Potential</title><title>Chemical research in Chinese universities</title><addtitle>Chem. Res. Chin. Univ</addtitle><addtitle>Chemical Research in Chinese University</addtitle><description>The host-guest interaction between cucurbit[8]uril（Q[8]） and chrysin（CHR） has been studied by means of 1H NMR, mass spectrometry（MS）, differential thermal analysis（DTA）, and UV-Vis spectrophotometry. The results show that CHR forms a 1：1 inclusion complex with Q[8], with a binding constant of CHR with Q[8] by UV absorp- tion being 5.4 × 106. Phase solubility experiments show a 5.13-fold increase in the solubility of CHR through interac- tion with Q[8] {c（Q[8]）=10-4 real/L}. A study of the evolution of UV absorption spectra with time shows that Q[8] significantly increases the stability of CHR. The antioxidant activity of CHR-Q[8] has been tested by the ABTS me- thod. The CHR-Q[8] inclusion complex shows a better scavenging effect towards the ABTS radical than CHR, with respective IC50 values of 1.05 ×10-6 and 3.07× 10-6 mol/L. In vitro release studies have shown that CHR-Q[8] has a sustained release effcct.</description><subject>Absorption spectra</subject><subject>Analytical Chemistry</subject><subject>Antioxidants</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Inorganic Chemistry</subject><subject>Mass spectrometry</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organic Chemistry</subject><subject>Physical Chemistry</subject><subject>Solubility</subject><subject>Spectrophotometry</subject><subject>Stability</subject><subject>Sustained release</subject><subject>Thermal analysis</subject><subject>主客体相互作用</subject><subject>包合作用</subject><subject>抗氧化能力</subject><subject>溶解性</subject><subject>白杨素</subject><subject>稳定性</subject><subject>紫外-可见分光光度法</subject><subject>葫芦</subject><issn>1005-9040</issn><issn>2210-3171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LAzEQxYMoWKsfwNuiV1cnf3bTPZZStVBQqJ5EQrrJtilr0iZZsN_elC3iSRiYGfi9ecND6BrDPQbgD4EBYSQHzHMOVZmPTtCAEAw5xRyfokGCirwCBufoIoQNAK3Kkg2QmTaNrmPIXJPNbN12wTh7WCZrvw_GZqkmXd35pYkfo8_OmzZLwCwpFlEuTWvi_i5buLbr50xalY1tNO7bKGlj9uqiTqtsL9FZI9ugr459iN4fp2-T53z-8jSbjOd5TRmNOQOaHqK65LooNRRFpWomSVErICNSclazspGSgWRM6oqTpgKtgHOlFDSqokN029_derfrdIhi4zpvk6XAFeM4RURHicI9VXsXgteN2HrzJf1eYBCHREWfqEi4OCQqDhrSa0Ji7Ur7P5f_Ed0cjdbOrnZJ9-tUckp5eobQH5jZhQw</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Xu, Zhiling</creator><creator>Lian, Xiaowei</creator><creator>Li, Mengjie</creator><creator>Zhang, Xiaodong</creator><creator>Wang, Yi</creator><creator>Tao, Zhu</creator><creator>Zhang, Qianjun</creator><general>Jilin University and The Editorial Department of Chemical Research in Chinese Universities</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20171001</creationdate><title>Effects of Inclusion of Chrysin in Cucurbit[8]uril on Its Stability, Solubility and Antioxidant Potential</title><author>Xu, Zhiling ; Lian, Xiaowei ; Li, Mengjie ; Zhang, Xiaodong ; Wang, Yi ; Tao, Zhu ; Zhang, Qianjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-403fec3e67e56e0559dc4a25cd0282674c46faa40a44ae972f90ed077ddd0fd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Absorption spectra</topic><topic>Analytical Chemistry</topic><topic>Antioxidants</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Inorganic Chemistry</topic><topic>Mass spectrometry</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organic Chemistry</topic><topic>Physical Chemistry</topic><topic>Solubility</topic><topic>Spectrophotometry</topic><topic>Stability</topic><topic>Sustained release</topic><topic>Thermal analysis</topic><topic>主客体相互作用</topic><topic>包合作用</topic><topic>抗氧化能力</topic><topic>溶解性</topic><topic>白杨素</topic><topic>稳定性</topic><topic>紫外-可见分光光度法</topic><topic>葫芦</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Zhiling</creatorcontrib><creatorcontrib>Lian, Xiaowei</creatorcontrib><creatorcontrib>Li, Mengjie</creatorcontrib><creatorcontrib>Zhang, Xiaodong</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Tao, Zhu</creatorcontrib><creatorcontrib>Zhang, Qianjun</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>CrossRef</collection><jtitle>Chemical research in Chinese universities</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Zhiling</au><au>Lian, Xiaowei</au><au>Li, Mengjie</au><au>Zhang, Xiaodong</au><au>Wang, Yi</au><au>Tao, Zhu</au><au>Zhang, Qianjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Inclusion of Chrysin in Cucurbit[8]uril on Its Stability, Solubility and Antioxidant Potential</atitle><jtitle>Chemical research in Chinese universities</jtitle><stitle>Chem. 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The CHR-Q[8] inclusion complex shows a better scavenging effect towards the ABTS radical than CHR, with respective IC50 values of 1.05 ×10-6 and 3.07× 10-6 mol/L. In vitro release studies have shown that CHR-Q[8] has a sustained release effcct.</abstract><cop>Changchun</cop><pub>Jilin University and The Editorial Department of Chemical Research in Chinese Universities</pub><doi>10.1007/s40242-017-7096-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Absorption spectra Analytical Chemistry Antioxidants Chemistry Chemistry and Materials Science Chemistry/Food Science Inorganic Chemistry Mass spectrometry NMR Nuclear magnetic resonance Organic Chemistry Physical Chemistry Solubility Spectrophotometry Stability Sustained release Thermal analysis 主客体相互作用 包合作用 抗氧化能力 溶解性 白杨素 稳定性 紫外-可见分光光度法 葫芦 |
| title | Effects of Inclusion of Chrysin in Cucurbit[8]uril on Its Stability, Solubility and Antioxidant Potential |
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