Characterizing the powder punch-face adhesive interaction during the unloading phase of powder compaction
The objective of this work is to measure the adhesive force profile between a punch face and powder compact in-die during the decompression phase of a tablet compaction process. An instrumented punch was developed for use on a single station compaction fixture mounted on a universal testing machine....
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Veröffentlicht in: | Powder technology 2017-06, Vol.315, p.410-421 |
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creator | Swaminathan, Shrikant Ramey, Brian Hilden, Jon Wassgren, Carl |
description | The objective of this work is to measure the adhesive force profile between a punch face and powder compact in-die during the decompression phase of a tablet compaction process. An instrumented punch was developed for use on a single station compaction fixture mounted on a universal testing machine. Adhesive force-displacement profiles were measured for acetaminophen, ibuprofen, lactose, mannitol, several grades of micro-crystalline cellulose, and blends containing magnesium stearate as a lubricant. The degree of compact solid fraction, the number of compacts produced in a row, and concentration of magnesium stearate in the blends affected the adhesive force profiles. The maximum adhesive force increased with increasing compact solid fraction and decreasing magnesium stearate concentration. An increase in the number of compression cycles increased the adhesive force between the powder compact and punch face, but the compression speed did not play a significant role in the adhesive interaction, at least over the range of speeds examined in the current work.
[Display omitted]
•A novel instrumented punch for measuring powder-punch adhesion is described.•The adhesive force-displacement data follow a bi-linear relationship.•Maximum adhesive force increases linearly with compact solid fraction.•Maximum adhesive force decreases with the addition of magnesium stearate.•Adhesion increases with number of compression cycles. |
doi_str_mv | 10.1016/j.powtec.2017.04.003 |
format | Article |
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[Display omitted]
•A novel instrumented punch for measuring powder-punch adhesion is described.•The adhesive force-displacement data follow a bi-linear relationship.•Maximum adhesive force increases linearly with compact solid fraction.•Maximum adhesive force decreases with the addition of magnesium stearate.•Adhesion increases with number of compression cycles.</description><identifier>ISSN: 0032-5910</identifier><identifier>EISSN: 1873-328X</identifier><identifier>DOI: 10.1016/j.powtec.2017.04.003</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Acetaminophen ; Adhesion force ; Adhesion tests ; Adhesives ; Analgesics ; Cellulose ; Compaction ; Compacts ; Compression ; Crystalline cellulose ; Decompression ; Ibuprofen ; Instrumented punch ; Lactose ; Magnesium ; Magnesium stearate ; Mannitol ; Picking and sticking ; Polymer blends ; Powder ; Studies ; Unloading</subject><ispartof>Powder technology, 2017-06, Vol.315, p.410-421</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright Elsevier BV Jun 15, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-14a04c464b7790d294dd849c3d9415be65a7e386f2175153a7ea85a96e3b24293</citedby><cites>FETCH-LOGICAL-c400t-14a04c464b7790d294dd849c3d9415be65a7e386f2175153a7ea85a96e3b24293</cites><orcidid>0000-0001-9573-707X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.powtec.2017.04.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids></links><search><creatorcontrib>Swaminathan, Shrikant</creatorcontrib><creatorcontrib>Ramey, Brian</creatorcontrib><creatorcontrib>Hilden, Jon</creatorcontrib><creatorcontrib>Wassgren, Carl</creatorcontrib><title>Characterizing the powder punch-face adhesive interaction during the unloading phase of powder compaction</title><title>Powder technology</title><description>The objective of this work is to measure the adhesive force profile between a punch face and powder compact in-die during the decompression phase of a tablet compaction process. An instrumented punch was developed for use on a single station compaction fixture mounted on a universal testing machine. Adhesive force-displacement profiles were measured for acetaminophen, ibuprofen, lactose, mannitol, several grades of micro-crystalline cellulose, and blends containing magnesium stearate as a lubricant. The degree of compact solid fraction, the number of compacts produced in a row, and concentration of magnesium stearate in the blends affected the adhesive force profiles. The maximum adhesive force increased with increasing compact solid fraction and decreasing magnesium stearate concentration. An increase in the number of compression cycles increased the adhesive force between the powder compact and punch face, but the compression speed did not play a significant role in the adhesive interaction, at least over the range of speeds examined in the current work.
[Display omitted]
•A novel instrumented punch for measuring powder-punch adhesion is described.•The adhesive force-displacement data follow a bi-linear relationship.•Maximum adhesive force increases linearly with compact solid fraction.•Maximum adhesive force decreases with the addition of magnesium stearate.•Adhesion increases with number of compression cycles.</description><subject>Acetaminophen</subject><subject>Adhesion force</subject><subject>Adhesion tests</subject><subject>Adhesives</subject><subject>Analgesics</subject><subject>Cellulose</subject><subject>Compaction</subject><subject>Compacts</subject><subject>Compression</subject><subject>Crystalline cellulose</subject><subject>Decompression</subject><subject>Ibuprofen</subject><subject>Instrumented punch</subject><subject>Lactose</subject><subject>Magnesium</subject><subject>Magnesium stearate</subject><subject>Mannitol</subject><subject>Picking and sticking</subject><subject>Polymer blends</subject><subject>Powder</subject><subject>Studies</subject><subject>Unloading</subject><issn>0032-5910</issn><issn>1873-328X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kM1LxDAQxYMouK7-Bx4KnlsnTfqRiyCLX7DgRcFbyCZTm7Lb1KRd0b_eLNWrp-ENv_eGeYRcUsgo0PK6ywb3OaLOcqBVBjwDYEdkQeuKpSyv347JIm7ytBAUTslZCB0AlIzCgthVq7zSI3r7bfv3ZGwxiWEGfTJMvW7TRmlMlGkx2D0mto9kxK3rEzP5P8fUb50yBzW0KmDimr8Q7XbDzJ-Tk0ZtA178ziV5vb97WT2m6-eHp9XtOtUcYEwpV8A1L_mmqgSYXHBjai40M4LTYoNloSpkddnktCpowaJSdaFEiWyT81ywJbmacwfvPiYMo-zc5Pt4UlLBK6goE2Wk-Exp70Lw2MjB253yX5KCPJQqOzmXKg-lSuAyVhhtN7MN4wd7i14GbbHXaKxHPUrj7P8BP-H7gxY</recordid><startdate>20170615</startdate><enddate>20170615</enddate><creator>Swaminathan, Shrikant</creator><creator>Ramey, Brian</creator><creator>Hilden, Jon</creator><creator>Wassgren, Carl</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7ST</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>JG9</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0001-9573-707X</orcidid></search><sort><creationdate>20170615</creationdate><title>Characterizing the powder punch-face adhesive interaction during the unloading phase of powder compaction</title><author>Swaminathan, Shrikant ; Ramey, Brian ; Hilden, Jon ; Wassgren, Carl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-14a04c464b7790d294dd849c3d9415be65a7e386f2175153a7ea85a96e3b24293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acetaminophen</topic><topic>Adhesion force</topic><topic>Adhesion tests</topic><topic>Adhesives</topic><topic>Analgesics</topic><topic>Cellulose</topic><topic>Compaction</topic><topic>Compacts</topic><topic>Compression</topic><topic>Crystalline cellulose</topic><topic>Decompression</topic><topic>Ibuprofen</topic><topic>Instrumented punch</topic><topic>Lactose</topic><topic>Magnesium</topic><topic>Magnesium stearate</topic><topic>Mannitol</topic><topic>Picking and sticking</topic><topic>Polymer blends</topic><topic>Powder</topic><topic>Studies</topic><topic>Unloading</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swaminathan, Shrikant</creatorcontrib><creatorcontrib>Ramey, Brian</creatorcontrib><creatorcontrib>Hilden, Jon</creatorcontrib><creatorcontrib>Wassgren, Carl</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Materials Research Database</collection><collection>Environment Abstracts</collection><jtitle>Powder technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Swaminathan, Shrikant</au><au>Ramey, Brian</au><au>Hilden, Jon</au><au>Wassgren, Carl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterizing the powder punch-face adhesive interaction during the unloading phase of powder compaction</atitle><jtitle>Powder technology</jtitle><date>2017-06-15</date><risdate>2017</risdate><volume>315</volume><spage>410</spage><epage>421</epage><pages>410-421</pages><issn>0032-5910</issn><eissn>1873-328X</eissn><abstract>The objective of this work is to measure the adhesive force profile between a punch face and powder compact in-die during the decompression phase of a tablet compaction process. An instrumented punch was developed for use on a single station compaction fixture mounted on a universal testing machine. Adhesive force-displacement profiles were measured for acetaminophen, ibuprofen, lactose, mannitol, several grades of micro-crystalline cellulose, and blends containing magnesium stearate as a lubricant. The degree of compact solid fraction, the number of compacts produced in a row, and concentration of magnesium stearate in the blends affected the adhesive force profiles. The maximum adhesive force increased with increasing compact solid fraction and decreasing magnesium stearate concentration. An increase in the number of compression cycles increased the adhesive force between the powder compact and punch face, but the compression speed did not play a significant role in the adhesive interaction, at least over the range of speeds examined in the current work.
[Display omitted]
•A novel instrumented punch for measuring powder-punch adhesion is described.•The adhesive force-displacement data follow a bi-linear relationship.•Maximum adhesive force increases linearly with compact solid fraction.•Maximum adhesive force decreases with the addition of magnesium stearate.•Adhesion increases with number of compression cycles.</abstract><cop>Lausanne</cop><pub>Elsevier B.V</pub><doi>10.1016/j.powtec.2017.04.003</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9573-707X</orcidid></addata></record> |
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subjects | Acetaminophen Adhesion force Adhesion tests Adhesives Analgesics Cellulose Compaction Compacts Compression Crystalline cellulose Decompression Ibuprofen Instrumented punch Lactose Magnesium Magnesium stearate Mannitol Picking and sticking Polymer blends Powder Studies Unloading |
title | Characterizing the powder punch-face adhesive interaction during the unloading phase of powder compaction |
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