Ronald D. Randel Lectureship Part II: Interferons during Early Pregnancy and Fetal Response to Viral Infection
An abstract of a study by Hansen et al detailing interferons (IFN) during early pregnancy and fetal response to viral infection in cattle is presented. IFN are cytokines induced in cells by viral infections that provide a first line of defense against other viral infections. These cytokines are deri...
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| Veröffentlicht in: | Journal of animal science 2017-01, Vol.95, p.33 |
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| creator | Hansen, T R Van Campen, H Bishop, J V Knapek, K |
| description | An abstract of a study by Hansen et al detailing interferons (IFN) during early pregnancy and fetal response to viral infection in cattle is presented. IFN are cytokines induced in cells by viral infections that provide a first line of defense against other viral infections. These cytokines are derived from a multi-gene family and classified as Type I IFNs and Type II IFNg. The impact of maternal bovine viral diarrhea virus (BVDV) infection on IFNs, ISGs and fetal development was examined during pregnancy. Infection of pregnant cows (d75) with ncpBVDV induces a rapid innate immune response (IFN-I and ISGs) that decreases viral replication and leads to the induction of adaptive immune responses that clears the virus in xx 3 weeks. Clarifying the mechanisms of fetal BVDV persistence in the face of activated IFNs will lead to better management tools, detection, biocontainment and antiviral treatments. |
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Randel Lectureship Part II: Interferons during Early Pregnancy and Fetal Response to Viral Infection</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Hansen, T R ; Van Campen, H ; Bishop, J V ; Knapek, K</creator><creatorcontrib>Hansen, T R ; Van Campen, H ; Bishop, J V ; Knapek, K</creatorcontrib><description>An abstract of a study by Hansen et al detailing interferons (IFN) during early pregnancy and fetal response to viral infection in cattle is presented. IFN are cytokines induced in cells by viral infections that provide a first line of defense against other viral infections. These cytokines are derived from a multi-gene family and classified as Type I IFNs and Type II IFNg. The impact of maternal bovine viral diarrhea virus (BVDV) infection on IFNs, ISGs and fetal development was examined during pregnancy. Infection of pregnant cows (d75) with ncpBVDV induces a rapid innate immune response (IFN-I and ISGs) that decreases viral replication and leads to the induction of adaptive immune responses that clears the virus in xx 3 weeks. Clarifying the mechanisms of fetal BVDV persistence in the face of activated IFNs will lead to better management tools, detection, biocontainment and antiviral treatments.</description><identifier>ISSN: 0021-8812</identifier><identifier>EISSN: 1525-3163</identifier><language>eng</language><publisher>Champaign: Oxford University Press</publisher><subject>Adaptive immunity ; Cattle ; Cytokines ; Diarrhea ; Fetuses ; Immune response ; Immune system ; Infections ; Innate immunity ; Interferon ; Management tools ; Pregnancy ; Prenatal development ; Viral infections ; Viruses</subject><ispartof>Journal of animal science, 2017-01, Vol.95, p.33</ispartof><rights>Copyright American Society of Animal Science Jan 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Hansen, T R</creatorcontrib><creatorcontrib>Van Campen, H</creatorcontrib><creatorcontrib>Bishop, J V</creatorcontrib><creatorcontrib>Knapek, K</creatorcontrib><title>Ronald D. 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Clarifying the mechanisms of fetal BVDV persistence in the face of activated IFNs will lead to better management tools, detection, biocontainment and antiviral treatments.</description><subject>Adaptive immunity</subject><subject>Cattle</subject><subject>Cytokines</subject><subject>Diarrhea</subject><subject>Fetuses</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Infections</subject><subject>Innate immunity</subject><subject>Interferon</subject><subject>Management tools</subject><subject>Pregnancy</subject><subject>Prenatal development</subject><subject>Viral infections</subject><subject>Viruses</subject><issn>0021-8812</issn><issn>1525-3163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNjssKwjAQRYMoWB__MOC6krTW19YHFlyUIm4l2KlWwqRO0oV_bxZ-gKsLl3MutycilSVZnKpl2heRlImK12uVDMXIuZeUKsk2WSSotKRNBfs5lJoqNHDGu-8Y3bNpodDsIc-3kJNHrpEtOag6bugBB83mAwXjgzTdPxBsOKLXBkp0bQARvIVrw6HJqQ6rjaWJGNTaOJz-cixmx8Nld4pbtu8Onb-9bMfhkbupzWIl05VUMv2P-gKEQkoG</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Hansen, T R</creator><creator>Van Campen, H</creator><creator>Bishop, J V</creator><creator>Knapek, K</creator><general>Oxford University Press</general><scope>3V.</scope><scope>7RQ</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>S0X</scope><scope>U9A</scope></search><sort><creationdate>20170101</creationdate><title>Ronald D. 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Randel Lectureship Part II: Interferons during Early Pregnancy and Fetal Response to Viral Infection</atitle><jtitle>Journal of animal science</jtitle><date>2017-01-01</date><risdate>2017</risdate><volume>95</volume><spage>33</spage><pages>33-</pages><issn>0021-8812</issn><eissn>1525-3163</eissn><abstract>An abstract of a study by Hansen et al detailing interferons (IFN) during early pregnancy and fetal response to viral infection in cattle is presented. IFN are cytokines induced in cells by viral infections that provide a first line of defense against other viral infections. These cytokines are derived from a multi-gene family and classified as Type I IFNs and Type II IFNg. The impact of maternal bovine viral diarrhea virus (BVDV) infection on IFNs, ISGs and fetal development was examined during pregnancy. Infection of pregnant cows (d75) with ncpBVDV induces a rapid innate immune response (IFN-I and ISGs) that decreases viral replication and leads to the induction of adaptive immune responses that clears the virus in xx 3 weeks. Clarifying the mechanisms of fetal BVDV persistence in the face of activated IFNs will lead to better management tools, detection, biocontainment and antiviral treatments.</abstract><cop>Champaign</cop><pub>Oxford University Press</pub></addata></record> |
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| ispartof | Journal of animal science, 2017-01, Vol.95, p.33 |
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| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adaptive immunity Cattle Cytokines Diarrhea Fetuses Immune response Immune system Infections Innate immunity Interferon Management tools Pregnancy Prenatal development Viral infections Viruses |
| title | Ronald D. Randel Lectureship Part II: Interferons during Early Pregnancy and Fetal Response to Viral Infection |
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